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| 1 | Treatment of laryngopharyngeal reflux disease: A systematic review显示文摘BACKGROUNG For a long time,laryngopharyngeal reflux disease(LPRD)has been treated by proton pump inhibitors(PPIs)with an uncertain success rate.AIM To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD treatment.METHODS Three authors conducted a PubMed search to identify papers published between January 1990 and February 2019 about the treatment of LPRD.Clinical prospective or retrospective studies had to explore the impact of medical treatment(s)on the clinical presentation of suspected or confirmed LPRD.The criteria for considering studies for the review were based on the population,intervention,comparison,and outcome framework.RESULTS The search identified 1355 relevant papers,of which 76 studies met the inclusion criteria,accounting for 6457 patients.A total of 64 studies consisted of empirical therapeutic trials and 12 were studies where authors formally identified LPRD with pH-monitoring or multichannel intraluminal impedance-pH monitoring(MII-pH).The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 wk.The most used PPIs were omeprazole,esomeprazole,rabeprazole,lansoprazole and pantoprazole with a success rate ranging from 18%to 87%.Other composite treatments have been prescribed including PPIs,alginate,prokinetics,and H2 Receptor antagonists.CONCLUSION Regarding the development of MII-pH and the identification of LPRD subtypes(acid,nonacid,mixed),future studies are needed to improve the LPRD treatment considering all subtypes of reflux. | Jerome R Lechien Francois Mouawad Maria R Barillari Andrea Nacci Seyyedeh Maryam Khoddami Necati Enver Sampath Kumar Raghunandhan Christian Calvo-Henriquez Young-Gyu Eun Sven Saussez | 2019 | World Journal of Clinical Cases2019，7，19： | 9 |
| 2 | Ultrasound Doppler system for two-dimensional flow mapping in liquid metals显示文摘 | Sven Franke Lars Büttner Jürgen Czarske Dirk R?biger Sven Eckert | 2010 | Flow Measurement and Instrumentation2010，，3： | 3 |
| 3 | Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings显示文摘 | Andreas A. Schnitzbauer Sven A. Lang Holger Goessmann Silvio Nadalin Janine Baumgart Stefan A. Farkas Stefan Fichtner-Feigl Thomas Lorf Armin Goralcyk Rüdiger H?rbelt Alexander Kroemer Martin Loss Petra Rümmele Marcus N. Scherer Winfried Padberg Alfred K? | 2012 | Annals of Surgery2012，，3： | 2 |
| 4 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 5 | Stellenwert der Kipptischuntersuchung im Vergleich zum Schellong-Test bei orthostaseinduzierten Kreislaufdysregulationen/Synkopen显示文摘 | Sven Jungblut* Hagen Frickmann* Albrecht R?mer Hans Joachim Gilfrich | 2006 | Medizinische Klinik2006，，3： | 2 |
| 6 | Bovine β-defensins: identification and characterization of novel bovine β-defensin genes and their expression in mammarygland tissue显示文摘 | Susanne R Kay E Sven P | 2004 | Mammalian Genome2004，15，10： | 1 |
| 7 | Conductivity in polyacetytene 3 ab initio calculations for a two - site model for electron transfer显示文摘 | Lucia R M Sven L | 1996 | J Phys Chem1996，，100： | 1 |
| 8 | Synergistic enzyme mechanisms and effects of sequential enzyme additions on degradation of water insoluble wheat arabinoxylan显示文摘 | Sorensen Hanne R Pedersen Sven Meyer Anne S | 2007 | Enzyme and Microbial Technology2007，40，4： | 1 |
| 9 | Extracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells: Implications in Acute Myocardial Infarction显示文摘 | Roland Schmidt Andreas Bültmann Martin Ungerer Nader Joghetaei ?zgür Bülbül Sven Thieme Triantafyllos Chavakis Bryan P. Toole Meinrad Gawaz Albert Sch?mig Andreas E. May | 2006 | Circulation2006，，6： | 1 |
| 10 | High sensitivity ofBRCA1 -deficient mammary tumors to the PARP inhibitorAZD2281 alone and incombination with platinum drugs 显示文摘 | Sven R Janneke EJ Ariena K | 2008 | ProcNatl Acad Sci USA2008，105，17： | 1 |
| 11 | Mercury emission control in coal-fired plants: The role of wet scrubbers显示文摘 | Mercedes D S Sven U Klaus R G H | 2007 | Fuel Processing Technology2007，88，3： | 1 |
| 12 | High-efficiency coal-fired power plants development and perspectives显示文摘 | J?rgen Bugge Sven Kj?r Rudolph Blum | 2005 | Energy2005，，10： | 1 |
| 13 | Intrasseous ultrasound in the placement of pedicle screws in the lumbar spine显示文摘 | Sven R Kantelhardt MD Christoph H | 2009 | Spine2009，4，40： | 1 |
| 14 | Caleaneal fracturesopen reduction and internal fixation (ORIF)显示文摘 | Hans Zi Stefan R Sven B | | 0，，： | 1 |
| 15 | Synthetic seismograms:a finite difference approach显示文摘 | KELLY K R WARD R W SVEN Treitel | 1976 | Geophysics1976，41，1： | 1 |
| 16 | Mercury emission control in coal-fired plants:The role of wet scrubbers 显示文摘 | Mercedes D S Sven U Klaus R G H | 2007 | Fuel Processing Technology2007，88，3： | 1 |
| 17 | Synthetic seismograms : a finite-difference approach 显示文摘 | KELLY K R WARD R W SVEN T | 1976 | Geophysics1976，41，1： | 1 |
| 18 | Mercury emis- sion control in coal-fired plants:the role of wet scrub- bers 显示文摘 | Mercedes D S Sven U Klaus R G H | 2007 | Fuel Processing Technology2007，88，3： | 1 |
| 19 | Organic-inorganic interactions and sandstone diagenesis显示文摘 | Surdam R C Crossey L J Sven Sven E | 1989 | AAPG Bulletin1989，73，1： | 1 |
| 20 | Efficiencies of designed enzyme combinations in releasing arabinose and xylose from wheat arabinoxylan in an industrial ethanol fermentation residue显示文摘 | HANNE R SORENSEN SVEN PEDERSEN | 2005 | Enzyme and Microbial Technology2005，36，5： | 1 |
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