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| 1 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Polyurethane-ductilized epoxy resins显示文摘 | STEFANI P M MOSCHIAR S M ARANGUREN M I | 1998 | J Appl Polym Sci1998，68，11： | 1 |
| 4 | Improved synthesis of benzotriazoles and 1-acylbenzotriazoles by ultrasound irradiation 显示文摘 | Pereira C M P Stefani H A Guzenc K P | 2007 | Letters in Organic Chemistry2007，4，1： | 1 |
| 5 | Non Sedgkm lymphoma of the ureter; a rare disease 显示文摘 | Celia A De Stefani S Bruschi M | 2004 | Arch Ital Urol Androl2004，76，4： | 1 |
| 6 | Biofeed-back,electrical stimulation,pelvic floor muscle exercises,and vaginal cones:a combined rehabilitative approach for sexual dysfunction associated with urinary incontinence显示文摘 | Rivalta M Sighinolfi M C De Stefani S | | 0，，06： | 1 |
| 7 | Biofeedback, electrical stimulation, pelvic floor muscle exercises, and vaginal cones: a com- bined rehabilitative approach for sexual dysfunction associated with urinary incontinence显示文摘 | Rivalta M Sighinolfi MC De Stefani S | 2009 | J Sex Med2009，6，： | 1 |
| 8 | Apparent digestibility of different ingredients in diets for bullfrog Rana catesbeiana Tadpoles 显示文摘 | SECCO E M DE STEFANI M V VIDOTTI R M | 2005 | Journal of the World Aquaculture Society2005，36，1： | 1 |
| 9 | Effect of enzymatic debridement with collagenase on acute and chronic hard - to - heal wounds 显示文摘 | Marazzi M Stefani A Chiaratti A | 2006 | J Wound Care2006，15，5： | 1 |
| 10 | Noninvasive management of obstructing ureteral stones using electromagnetic extracorporeal shock wave lithotripsy显示文摘 | Sighinolfi M C Micali S De Stefani S | 2008 | Surg Endosc2008，22，5： | 1 |
| 11 | Measuring the Armature Position in a Railgun Using Embedded Permanent Magnets显示文摘 | Vanderburg A M Stefani F | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
| 12 | The let-7microRNA represses cell prolif-eration pathways in human cells显示文摘 | Johnson CD Esquela-Kerscher A Stefani G Byrom M Kelnar K Ovcharenko D | 2007 | Cancer Res2007，67，16： | 1 |
| 13 | Sensitive quantitative assays for Tau and phospho-Tau in transgenic mouse models显示文摘 | Christopher M Acker Stefanie K Forest Ray Zinkowski | 2013 | Neurobiol Aging2013，34，1： | 1 |
| 14 | Alpha-synuclein and protein degradation systems:a reciprocal relationship显示文摘 | Xilouri M Brekk O R Stefanis L | 2013 | Mol Neurobiol2013，47，2： | 1 |
| 15 | Character- ization of epoxy foams显示文摘 | STEFANI P M BARCHI A T SABUGAL J | 2003 | Journal of Applied Polymer Sci- ence2003，90，11： | 1 |
| 16 | Potential plasma markers of type 1 and type 2 leprosy reactions: a preliminary report 显示文摘 | Mariane M Stefani | 2009 | BMC Infectious Diseases2009，9，： | 1 |
| 17 | Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity显示文摘 | Stefani M | 2010 | FEBS J2010，277，： | 1 |
| 18 | Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging显示文摘 | Hannes G. Kenngott Martin Wagner Matthias Gondan Felix Nickel Marco Nolden Andreas Fetzer Jürgen Weitz Lars Fischer Stefanie Speidel Hans-Peter Meinzer Dittmar B?ckler Markus W. Büchler Beat P. Müller-Stich | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 19 | Physi- cal and Mechanical Properties of Compression Molded and Solution Casting Soybean Protein Concentrate Based Films显示文摘 | CIANNAMEA E M STEFANI P M RUSECKAITE R | 2014 | Food Hydrocolloids2014，，8： | 1 |
| 20 | Synthesis of ORMOSIL silica/rhodamine 6G:Powders and compacts显示文摘 | LARANJO M T STEFANI V BENVENUTTI E V | 2007 | Journal of Non-Crystalline Solids2007，353，1： | 1 |
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