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| 1 | Clinical significance of hepatitis B surface antigen mutants显示文摘Hepatitis B virus(HBV) infection is a major public health problem in many countries, with nearly 300 million people worldwide carrying HBV chronic infection and over 1 million deaths per year due to cirrhosis and liver cancer. Several hepatitis B surface antigen(HBs Ag) mutations have been described, most frequently due to a single amino acid substitution and seldom to a nucleotide deletion. The majority of mutations are located in the S region, but they have also been found in the pre-S1 and pre-S2 regions. Single amino acid substitutions in the major hydrophilic region of HBs Ag, called the 'a' determinant, have been associated with immune escape and the consequent failure of HBV vaccination and HBs Ag detection, whereas deletions in the pre-S1 or pre-S2 regions have been associated with the development of hepatocellular carcinoma. This review article will focus on the HBs Ag mutants and their biological and clinical implications. | Nicola Coppola Lorenzo Onorato Carmine Minichini Giovanni Di Caprio Mario Starace Caterina Sagnelli Evangelista Sagnelli | 2015 | World Journal of Hepatology2015，7，27： | 9 |
| 2 | TM6SF2 E167K variant predicts severe liver fibrosis for human immunodeficiency/hepatitis C virus co-infected patients, and severe steatosis only for a non-3 hepatitis C virus genotype显示文摘AIM To evaluate the impact of the Glu167Lys(E167K) transmembrane 6 superfamily member 2(TM6SF2) variant on the biochemical and morphologic expression of liver lesions in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) co-infected patients.METHODS The study comprised 167 consecutive patients with HIV/HCV coinfection and biopsy-proven chronic hepatitis. A pathologist graded liver fibrosis and necroinflammation using the Ishak scoring system, and steatosis using Kleiner's scoring system. Patients were genotyped for TM6SF2 E167K(rs58542926) by real-time Polymerase chain reaction. The 167 patients, 35 therapy-naive and 132 receiving ART, were prevalently males(73.6%), the median age was 40.7 years and the immunological condition good(median CD4+ cells/mm3 = 505.5).RESULTS The 17 patients with the TM6SF2 E167 K variant, compared with the 150 with TM6SF2-E/E, showed higher AST(P = 0.02) and alanine aminotransferase(P = 0.02) and higher fibrosis score(3.1 ± 2.0 vs 2.3 ± 1.5, P = 0.05). In a multivariate analysis, TM6SF2 E167 K was independently associated with severe fibrosis. The same analysis showed that HCV-genotype 3, present in 42.2% of patients was an independent predictor of severe steatosis. The association of TM6SF2 E167 K with severe steatosis, absent for the whole group of 167 patients, was re-evaluated separately for HCVgenotype 3 and non-3 patients: No factor was independently associated with severe steatosis in the HCV-genotype-3 subgroup, whereas an independent association was observed between severe steatosis and TM6SF2 E167 K in non-3 HCV genotypes. No association between the TM6SF2 E167 K variant and severe liver necroinflammation was observed.CONCLUSION In HIV/HCV coinfection the TM6SF2 E167 K variant is an independent predictor of severe fibrosis, but appears to be independently associated with severe steatosis only for patients with a non-3 HCV genotype. | Caterina Sagnelli Marco Merli Caterina Uberti-Foppa Hamid Hasson Anna Grandone Grazia Cirillo Stefania Salpietro Carmine Minichini Mario Starace Emanuela Messina Patrizia Morelli Emanuele Miraglia Del Giudice Adriano Lazzarin Nicola Coppola Evangelista Sagnelli | 2016 | World Journal of Gastroenterology2016，22，38： | 4 |
| 3 | Role of interleukin 28-B in the spontaneous and treatment-related clearance of HCV infection in patients with chronic HBV/HCV dual infection显示文摘 | N. Coppola A. Marrone M. Pisaturo M. Starace G. Signoriello I. Gentile L. E. Adinolfi E. Sagnelli R. Zampino | 2014 | European Journal of Clinical Microbiology & Infectious Diseases2014，，4： | 3 |
| 4 | Presentation, Outcomes, and Response to Therapy Among Patients with Acute Exacerbation of Chronic Hepatitis C显示文摘 | Evangelista Sagnelli Mariantonietta Pisaturo Maria Stanzione Vincenzo Messina Loredana Alessio Caterina Sagnelli Mario Starace Giuseppe Pasquale Nicola Coppola | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 3 |
| 5 | Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy:demographic,virological,and clinical features显示文摘Background:The data on hepatitis b virus(HBV)infection in immigrants population are scanty.The porpoise of this study was to define the demographic,virological,and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples,Italy.Methods:A screening for HBV infection was offered to 1,331 immigrants,of whom 1,212(91%)(831 undocumented immigrants and 381 refugees)accepted and were screened for hepatitis B surface antigen(HBsAg)and anti-hepatitis B core antibody(HBc).Those found to be HBsAg positive were further investigated at third-level infectious disease units.Results:Of the 1,212 immigrants screened,116(9.6%)were HBsAg positive,490(40.4%)were HBsAg negative/anti-HBc positive,and 606(50%)were seronegative for both.Moreover,21(1.7%)were anti-human immunodeficiency virus positive and 45(3.7%)were anti-hepatitis C virus positive.The logistic regression analysis showed that male sex(OR:1.79;95%CI:1.28-2.51),Sub-Saharan African origin(OR:6.18;95%CI:3.37-11.36),low level of schooling(OR:0.96;95%CI:0.94-0.99),and minor parenteral risks for acquiring HBV infection(acupuncture,tattoo,piercing,or tribal practices,OR:1.54;95%CI:1.1-2.16)were independently associated with ongoing or past HBV infection.Of the 116 HBsAg-positive immigrants,90(77.6%)completed their diagnostic itinerary at a third-level infectious disease unit:29(32.2%)were asymptomatic non-viremic HBsAg carriers,43(47.8%)were asymptomatic viremic carriers,14(15.6%)had chronic hepatitis,and four(4.4%)had liver cirrhosis,with superimposed hepatocellular carcinoma in two.Conclusions:The data illustrate the demographic,clinical and virological characteristics of HBV infection in immigrants in Italy and indicate the need for Italian healthcare authorities to enhance their support for providing screening,HBV vaccination,treatment,and educational programs for this populations. | Nicola Coppola Loredana Alessio Luciano Gualdieri Mariantonietta Pisaturo Caterina Sagnelli Carmine Minichini Giovanni Di Caprio Mario Starace Lorenzo Onorato Giuseppe Signoriello Margherita Macera Italo Francesco Angelillo Giuseppe Pasquale Evangelista Sagnelli | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 6 | HBV transmission from an occult carrier with five mutations in the major hydrophilic region of HBsAg to an immunosuppressed plasma recipient显示文摘 | Nicola Coppola Giovanna Loquercio Gilda Tonziello Rosa Azzaro Mariantonietta Pisaturo Gaetano Di Costanzo Mario Starace Giuseppe Pasquale Carmela Cacciapuoti Arnolfo Petruzziello | 2013 | Journal of Clinical Virology2013，，： | 2 |
| 7 | Insulin resistance and steatosis in HBV-HCV co-infected patients: Role of PNPLA3 polymorphisms and impact on liver fibrosis progression显示文摘AIM:To evaluate steatosis,insulin resistance(IR)and patatin-like phospholipase domain-containing 3(PNPLA3) and their relation to disease progression in hepatitis B and C viruses(HCV-HBV) coinfected patients.METHODS:Three hundred and thirty patients with biopsy proven chronic hepatitis were enrolled:66 had HBV-HCV,66 HBV and 198 HCV infection.Prevalence of steatosis,IR and PNPLA3 polymorphisms and their relation to anthropometric,biochemical,virological and histological parameters were evaluated.RESULTS:Prevalence of steatosis in group HBV-HCV was similar to that in HCV(47.0% vs 49.5%,respec-tively);group HBV showed the lowest steatosis(33.3%).Group HBV-HCV had a lesser degree of steatosis than HCV(P = 0.016),lower HCV RNA levels(P = 0.025) and lower prevalence and degree of IR(P = 0.01).PNPLA3 polymorphisms were associated with steatosis.Group HBV-HCV showed higher levels of liver fibrosis than group HCV(P = 0.001),but similar to that ob-served in HBV group.In HBV-HCV group,liver fibrosis was not associated with steatosis,IR or PNPLA3.HBV infection was the independent predictor of advanced liver fibrosis.CONCLUSION:HBV-HCV co-infected patients have lower degree of hepatic steatosis,IR and HCV RNA than HCV mono-infected;co-infected patients showed a more rapid liver fibrosis progression that seems to be due to the double infection and/or HBV dominance. | Rosa Zampino Adriana Boemio Aldo Marrone Luciano Restivo Maria Chiara Fascione Riccardo Nevola Luigi Elio Adinolfi Nicola Coppola Carmine Minichini Mario Starace Evangelista Sagnelli Grazia Cirillo Emanuele Miraglia del Giudice Maria Stanzione Emanuele Durante-Mangoni Giovanna Salzillo | 2014 | World Journal of Hepatology2014，6，9： | 2 |
| 8 | DNA damageinduced by temozolomide signals to both ATM and ATR: role ofthe mismatch repair system显示文摘 | Caporali S Falcinelli S Starace G | 2004 | Mol Pharmacol2004，66，3： | 1 |
| 9 | Anisotropy and magnetic field effects on the entanglement of a two qubit Heisenberg XY chain显示文摘 | KAMTA G L STARACE A F | 2002 | Phys Rev Lett2002，88，10： | 1 |
| 10 | Toll - like receptor 3activation induces antiviral immune responses in mousesertoli cells 显示文摘 | Starace D Galli R Paone A | 2008 | Biol Reprod2008，79，4： | 1 |
| 11 | An evaluation of the safety and efficacy of cariprazine in patients with aeute exacerbation of schizophrenia: a phase 1, randomized clinical trial显示文摘 | DURGAM S STARACE A LI D | 2014 | Schizophr Res2014，152，23： | 1 |
| 12 | TNF-α and IFN-γ regulate expression and function of the Fas system in the seminiferous epithelium 显示文摘 | Starace D D'Alessio A | 2000 | J Immunol2000，165，2： | 1 |
| 13 | Videodermoscopy: a useful tool for diagnosing congenital triangular alopecia显示文摘 | Iorizzo M Pazzaglia M Starace M | 2008 | Pedi- atr Dermatol2008，25，6： | 1 |
| 14 | Sertoli cells initiate testicular innate immune responses through TLR activation 显示文摘 | Riccioli A Starace D Galli R | 2006 | J Immunol2006，177，： | 1 |
| 15 | Ca(NO3)2-NaNO3-KNO3 molten salt mixtures for direct thermal energy storage systems in parabolic trough plants显示文摘 | Gomez J C Calvet N Starace A K | 2013 | J Sol Energy Eng2013，135，02： | 1 |
| 16 | Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition显示文摘 | Montagnoli A Guardavaocaro D Starace G | 1996 | Cell Growth Differ1996，7，： | 1 |
| 17 | Anisotropy and magnetic field effects on the entanglement of a two qubit Heisenber gXY Chain显示文摘 | Lagmago Kamta G Anthony F Starace | 2002 | Phys Rev Lett2002，88，10： | 1 |
| 18 | Anisotropy and Magnetic Field Effects on the Entanglement of a Two Qubit Heisenberg XY Chain显示文摘 | Kamta G L Starace A F | | 0，，： | 1 |
| 19 | Yellow nail syndrome: clinical experience in a series of 21 patients显示文摘 | Piraccini BM Urciuoli B Starace M | 2014 | J Dtsch Dermatol Ges2014，12，2： | 1 |
| 20 | Quality of life assessment in HIV-positive persons: application and validation of the WHOQOL-HIV, Italian version显示文摘 | Starace F Cafaro L hbrescia N | 2002 | AIDS Care2002，14，： | 1 |
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