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| 1 | 选择编程语言就像选择酒吧——Joshua Bloch访谈显示文摘本文是commmon Lisp专家Peter seibel对Google公司首席Java架构师Joshua Bloch的访谈,谈到程序员应该看什么书、如何能快速熟悉一种新语言以及为什么说选择编程语言就像选择酒吧。 | Peter Seibel 郝培强 | 2010 | 程序员2010，，11： | 6 |
| 2 | Miniature gastrointestinal endoscopy: Now and the future显示文摘Since its original application,gastrointestinal(GI)endoscopy has undergone many innovative transformations aimed at expanding the scope,safety,accuracy,acceptability and cost-effectiveness of this area of clinical practice.One method of achieving this has been to reduce the caliber of endoscopic devices.We propose the collective term“Miniature GI Endoscopy”.In this Opinion Review,the innovations in this field are explored and discussed.The progress and clinical use of the three main areas of miniature GI endoscopy(ultrathin endoscopy,wireless endoscopy and scanning fiber endoscopy)are described.The opportunities presented by these technologies are set out in a clinical context,as are their current limitations.Many of the positive aspects of miniature endoscopy are clear,in that smaller devices provide access to potentially all of the alimentary canal,while conferring high patient acceptability.This must be balanced with the costs of new technologies and recognition of device specific challenges.Perspectives on future application are also considered and the efforts being made to bring new innovations to a clinical platform are outlined.Current devices demonstrate that miniature GI endoscopy has a valuable place in investigation of symptoms,therapeutic intervention and screening.Newer technologies give promise that the potential for enhancing the investigation and management of GI complaints is significant. | John J McGoran Mark E McAlindon Prasad G Iyer Eric J Seibel Rehan Haidry Laurence B Lovat Sarmed S Sami | 2019 | World Journal of Gastroenterology2019，25，30： | 4 |
| 3 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 4 | Endogenous Glucocorticoids and Bone显示文摘While the adverse effects of glucocorticoids on bone are well described,positive effects of glucocorticoids on the differentiation of osteoblasts are also observed.These paradoxical effects of glucocorticoids are dose dependent.At both physiologicaland supraphysiological levels of glucocorticoids,osteoblasts and osteocytes are the major glucocorticoid target cells.However,the response of the osteoblasts to each of these is quite distinct.At physiology levels,glucocorticoids direct mesenchymal progenitor cells to differentiate towards osteoblasts and thus increase bone formation in a positive way.In contrast with ageing,the excess production of glucocorticoids,at both systemic and intracellular levels,appear to impact on osteoblast and osteocytes in a negative way in a similar fashion to that seen with therapeutic glucocorticoids.This review will focus on therole of glucocorticoids in normal bone physiology,with particular emphasis on the mechanism by which endogenous glucocorticoids impact on bone and its constituent cells. | Hong Zhou Mark S. Cooper Markus J. Seibel | 2013 | Bone Research2013，1，2： | 2 |
| 5 | Serum bone sialoprotein in patients with primary breast cancer is a prognostic marker for subsequent bone metastasis 显示文摘 | Diel IJ Solomayer EF Seibel MJ | 1999 | Clin Cancer Res1999，5，12： | 1 |
| 6 | Effects of Emulsifiers and Hydrocolloids in Whole Wheat Bread Quality: a Response Surface Methodology Study显示文摘 | Mettler E Seibel W | 1993 | Cereal Chemistry1993，70，4： | 1 |
| 7 | Molecular markers of bone turnover:Biochemical, technical and analytical aspects显示文摘 | Seibel MJ | 2000 | Ostcoporos Int2000，11，6： | 1 |
| 8 | Reactive oxygen and nitro- gen species balance in the determination of thyroid hormones-induced cardiac hypertrophy mediated by renin-angiotensin system 显示文摘 | Araujo AS Diniz GP Seibel FE | 2011 | Mol Cell Endocrinol2011，333，1： | 1 |
| 9 | Pivot hysteresis model for reinforced concrete members 显示文摘 | Dowell R K Seibel F Wilson E L | 1998 | ACI Structural Journal1998，95，5： | 1 |
| 10 | InterlabOratory variation of bio-chemical markers of bone turnover显示文摘 | Seibel M J Lang M Geilenkenser W J | | 0，，： | 1 |
| 11 | Lung ultrasound in acute and critical care medicine显示文摘 | Zechner PM Seibel A Aichinger G | | 0，，： | 1 |
| 12 | Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis 显示文摘 | Blair JM Zhou H Seibel MJ | 2006 | Nat Clin Praet Oncol2006，3，11： | 1 |
| 13 | Changes in Gas Production and Retention in Non-prefenmented Frozen Doughs显示文摘 | EI-Hady E A EI-Samahy S K Seibel W | 1996 | Cereal Chem1996，73，： | 1 |
| 14 | Impacts of ocean acidification on marine fauna and ecosystem processes 显示文摘 | Fabry V J Seibel B A Feely R A | 2008 | ICES Journal of Marine Sci ence2008，65，3： | 1 |
| 15 | Maturation and fertilization of mouse oocytes in serum-free media显示文摘 | Serta R T Seibel M M Kiessling A A | 1998 | Serono Symposium on Preimplantation Embryo Deveinpment1998，，45： | 1 |
| 16 | Glucocorticoid and thyroid hormone receptors in mitochondria of animal cells显示文摘 | Scheller K Seibel P Sekeris C E | | 0，，： | 1 |
| 17 | Femtosecond laser capsulotomy显示文摘 | FRIEDMAN N J PALANKER DV SCHUELE G ANDERSEN D MARCELLINO G SEIBEL BS | 2011 | J Cataract Refract Surg2011，37，7： | 1 |
| 18 | Insights intopolymer versus oligosaccharide synthesis: mutagenesis and mechanisticstudies of a novel levansucrase from Bacillus megaterium 显示文摘 | Homann A Biedendieck R Gotze S Jahn D Seibel J | 2007 | Biochem J2007，407，： | 1 |
| 19 | A new flux and stator resistance identifier for AC drive systems 显示文摘 | KERKMAN R J SEIBEL B J ROWAN T M | 1996 | IEEE Transactions on Industry Applications1996，32，3： | 1 |
| 20 | Impact of combined HDAC and mTOR inhibition on adhesion, migration and invasion of pros- tate cancer cells显示文摘 | Wedel S Hudak L Seibel JM | 2011 | Clin Exp Metastasis2011，28，5： | 1 |
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