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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | 青少年甘油磷酸胆碱代谢和心血管病的危险因素:一项队列研究显示文摘甘油磷酸胆碱(glycerophosphocholine,GPC)代谢物可调节动脉粥样硬化,从而导致心血管病风险。临床前期心血管病可能从青春期就开始。研究人员应用靶向血清脂质组学鉴定一组新的GPC,并测试在青春期时这些GPC中的任何一种是否与心血管病传统危险因子,如过量内脏脂肪、升高的血压、胰岛素抵抗和致动脉粥样硬化血脂异常相关。 | Syme C Czajkowski S Shin J Abrahamowicz M Leonard G Perron M Richer L Veillette S Gaudet D Strug L Wang Y Xu H Taylor G Paus T Bennett S Pausova Z 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 3 | Modification of Mg2Si morphology in squeeze cast Mg-Al-Zn-Si alloys by Ca or P addition 显示文摘 | Kim J J Kim K H Shin K S | 1999 | Scripta Materialia1999，41，3： | 3 |
| 4 | Operating characteristics of aerated submerged biofilm reactors for drinking water treatment 显示文摘 | Lim K H Shin H S | 1997 | Wat Sci Tech1997，36，12： | 2 |
| 5 | Damping mechanism and application of Fe-Mn Base Alloy 显示文摘 | Jee K K Jang W Y Baik S H Shin M C | 1999 | Materials Science and Engineering1999，，273275： | 2 |
| 6 | Position control of a two-link flexible manipulator featuring piezoelectric actuators and sensors显示文摘 | Shin H C Choi S B | 2001 | Mechatronics2001，，11： | 2 |
| 7 | Low resistivity indium tin oxide films deposited by unbalanced DC magnetron sputtering 显示文摘 | Shin S H Shin J H Park K J | 1999 | Thin Solid Films1999，341，12： | 1 |
| 8 | Cecropin A - magainin 2 hybrid peptides having potent antimicrobial activity with low hemolytic effect显示文摘 | Shin S Y Kang J H Lee M K | 1998 | Biochem Mol Biol Int1998，44，6： | 1 |
| 9 | Transmit power allocation for a modified V-BLAST system显示文摘 | Nam S H Shin O S Lee K B | 2004 | IEEE Transactions on Communications2004，52，7： | 1 |
| 10 | Efficient multilevel successive elimination algorithms for block matching motion estimation 显示文摘 | Shin S C Baik H | 2002 | Vision Image and Signal Processing IEE Proc2002，149，2： | 1 |
| 11 | An anti-apoptotic protein human survivin is a direct inhibitor of Caspase-3 and-7显示文摘 | Sung B J Cho YS Kim H J Ha NC Hwang JI | 2001 | Biochenistry2001，40，4： | 1 |
| 12 | Effect of shear stress on granulation in oxygen aerobic upflow sludge bed reactors 显示文摘 | Shin H S Lira K H Park H S | 1992 | Water Sci Technol1992，26，34： | 1 |
| 13 | Body composition changes with age have gender-specific impacts on bone mineral density显示文摘 | Lim S Joung H Shin C S | 2004 | Bone2004，35，3： | 1 |
| 14 | Calcium zinc borosilicate glass with high thermal expansion coefficient for LTCC Applications显示文摘 | PARK J S KIM Y SHIN H | 2008 | J Am Ceram Soc2008，91，11： | 1 |
| 15 | Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions显示文摘 | SHIN T Y LEE K B KIM S H TA Y | 2002 | Immunopharmacology & Immunotoxicology2002，24，3： | 1 |
| 16 | Berberine activates GLUT1-mediated glueose uptake in 3T3-L1 adipoeytes显示文摘 | KIM S H SHIN E J KIM E D | 2007 | Biol Pharm Bull2007，30，： | 1 |
| 17 | Phosphate transport in Arabidopsis: Phtl ;1 and Phtl ;4 play a major role in phosphate acquisition from both low- and high-phosphate environments显示文摘 | Shin H Shin H S Dewbre G R | 2004 | Plant J2004，39，： | 1 |
| 18 | Conversion of food waste into hydrogen by thermophilic acidogenesis 显示文摘 | Shin H S Youn J H | 2005 | Biodegradation2005，16，1： | 1 |
| 19 | Medullary thyroid carcinoma: comparison with papillary thyroid carcinoma and application of current sonographic cdteria显示文摘 | Lee S Shin J H Han B K | 2010 | AJR Am J Roentgenol2010，194，4： | 1 |
| 20 | Effects of limiting nutrients and N: P ratios on the phytoplankton growth in a shallow hypertrophic reservoir显示文摘 | Kim H S Hwang S J Shin J K | 2007 | Hydrobiologia2007，581，： | 1 |
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