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| 1 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 2 | Hydrographic field investigations in the Northern South China Sea by open cruises during 2004-2013显示文摘 | Lili Zeng Qiang Wang Qiang Xie Ping Shi Lei Yang Yeqiang Shu Ju Chen Dandan Sui Yunkai He Rongyu Chen Dongxiao Wang | 2015 | Science Bulletin2015，60，6： | 10 |
| 3 | Model of nonlinear coupled thermo-hydro-elastodynamics response for a saturated poroelastic medium显示文摘Based on the Biot’s wave equation and theory of thermodynamic, Darcy law of fluid and the modified Fourier law of heat conduction, a nonlinear fully coupled thermo-hydro-elastodynamic response model (THMD) for saturated porous medium is derived. The compressibility of the medium, the influence of fluid flux on the heat flux, and the influence of change of temperature on the fluid flux are considered in this model. With some simplification, the coupled nonlinear thermo-hydro-elastodynamic response model can be reduced to the thermo-elastodynamic (TMD) model based on the traditional Fourier law and, further more, to the Biot’s wave equation without considering the heat phase. At last, the problem of one dimensional cylindrical cavity subjected to a time-dependent thermal/mechanical shock is analyzed by using the Laplace technique, the numerical results are used to discuss the influence of Biot’s modulus M and coefficient of thermoos-mosis on displacement and to compare with the results of thermo-elastodynamic response to ascertain the validity of this model. | LIU GanBin XIE KangHe ZHENG RongYue | 2009 | Science China(Technological Sciences)2009，52，8： | 9 |
| 4 | Internal tide characteristics over northern South China Sea continental slope显示文摘21-day in-situ ADCP current and CTD data from an anchored observational station by R/V Shiyan 3 are used to investigate the characteristics of internal tide in the northern South China Sea continental slope. The results show that tide and internal tide are both mixed type in the observed region and dominated by diurnals; the maximum internal tidal major axes of K1, O1 were largest and reached 11 cm/s, 10 cm/s, respectively, and their current vectors rotate anticlockwise. The 300 m-deep internal tide presents obvious quasi-diurnal oscillation and its average amplitude reaches 50 m. Furthermore, internal tide carried high energy; in the upper layers above 140 m, the kinetic energy of internal tides accounts for 15%-37% of overall kinetic energy, most of internal tide energy concentrates around the thermocline. | GUO Pu FANG Wendong GAN Zijun CHEN Rongyu LONG Xiaomin | 2006 | Chinese Science Bulletin2006，51，B12： | 8 |
| 5 | Cyclic performance and simplified pushover analyses of precast segmental concrete bridge columns with circular section显示文摘In recent years, precast segmental concrete bridge columns became prevalent because of the benefits of accelerated construction, low environmental impact, high quality and low life cycle costs. The lack of a detailed configuration and appropriate design procedure to ensure a comparable performance with monolithic construction has impeded this structural system from being widely used in areas of high seismicity. In this study, precast segmental bridge column cyclic loading tests were conducted to investigate the performance of unbonded post-tensioned segmental bridge columns. One monolithic and two precast segmental columns were tested. The precast segmental column exhibited minor damage and small residual displacement after the maximum 7% cyclic drift; energy dissipation(ED) can be enhanced byadding ED bars. The experimental results were modeled by a simplified pushover method(SPOM), as well as a fiber model(FIBM) finite element method. Forty-five cases of columns with different aspect ratios, axial load ratios and ED bar ratios were analyzed with the SPOM and FIBM, respectively. Using these parametric results, a simplified design method was suggested by regressive analysis. Satisfactory correlation was found between the experimental results and the simplified design method for precast segmental columns with different design parameters. | Bu Zhanyu Guo Jian Zheng Rongyue Song Jianwei George C.Lee | 2016 | Earthquake Engineering and Engineering Vibration2016，15，2： | 8 |
| 6 | Research on Radiation Characteristics of Polymeric Plastic Fiber显示文摘The anti-radiation mechanism of polymeric plastic fiber is analyzed. The radiation characteristic of this type fiber is studied. Our experimental results indicate that under the low radiation dosage (below 1 kGy) the plastic optical fiber’s transmission rate rises instead of descends while this type of fiber is radiated by γ ray, electron beam and proton beam respectively. After a period of time, it gradually reaches a constant value. But under the high radiation dosage (above 1 kGy) the fiber’s transmission rate descends after radiation. Later, it gradually goes up to a constant value. | 殷宗敏 Li Rongyu Ge Wenping Liu Rui | 2001 | High Technology Letters2001，7，2： | 5 |
| 7 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 8 | Fault-tolerant control with mixed aerodynamic surfaces and RCS jets for hypersonic reentry vehicles显示文摘This paper proposes a fault-tolerant strategy for hypersonic reentry vehicles with mixed aerodynamic surfaces and reaction control systems(RCS) under external disturbances and subject to actuator faults.Aerodynamic surfaces are treated as the primary actuator in normal situations,and they are driven by a continuous quadratic programming(QP) allocator to generate torque commanded by a nonlinear adaptive feedback control law.When aerodynamic surfaces encounter faults,they may not be able to provide sufficient torque as commanded,and RCS jets are activated to augment the aerodynamic surfaces to compensate for insufficient torque.Partial loss of effectiveness and stuck faults are considered in this paper,and observers are designed to detect and identify the faults.Based on the fault identification results,an RCS control allocator using integer linear programming(ILP) techniques is designed to determine the optimal combination of activated RCS jets.By treating the RCS control allocator as a quantization element,closed-loop stability with both continuous and quantized inputs is analyzed.Simulation results verify the effectiveness of the proposed method. | He Jingjing Qi Ruiyun Jiang Bin Zhai Rongyu | 2017 | Chinese Journal of Aeronautics2017，30，2： | 4 |
| 9 | Investigation of flexible electrodes modified by TiN,Pt black and IrO_x显示文摘TiN,platinum (Pt) black and iridium oxide are introduced to the stimulating sites to improve the performance of the flexible electrode.Low temperature process is used to fabricate the modifying films.TiN is coated on the gold sites by magnetron sputtering while platinum black and iridium oxide are coated by electroplating and electrodeposition,respectively.The im-pedance of the electrode decreases dramatically after modification.The combined analysis of surface morphology and cyclic voltammograms (CV) in phosphate buffer saline (PBS) solution indicates that the modified electrode sites have larger elec-trode-electrolyte capacitance and smaller faradic resistance than unmodified sites,thus they have smaller electrochemical im-pedances. | LI XiaoQian PEI WeiHua TANG RongYu GUI Qiang GUO Kai WANG Yu CHEN HongDa | 2011 | Science China(Technological Sciences)2011，54，9： | 4 |
| 10 | A Novel Combinational Convolutional Neural Network for Automatic Food-Ingredient Classification显示文摘With the development of deep learning and Convolutional Neural Networks(CNNs),the accuracy of automatic food recognition based on visual data have significantly improved.Some research studies have shown that the deeper the model is,the higher the accuracy is.However,very deep neural networks would be affected by the overfitting problem and also consume huge computing resources.In this paper,a new classification scheme is proposed for automatic food-ingredient recognition based on deep learning.We construct an up-to-date combinational convolutional neural network(CBNet)with a subnet merging technique.Firstly,two different neural networks are utilized for learning interested features.Then,a well-designed feature fusion component aggregates the features from subnetworks,further extracting richer and more precise features for image classification.In order to learn more complementary features,the corresponding fusion strategies are also proposed,including auxiliary classifiers and hyperparameters setting.Finally,CBNet based on the well-known VGGNet,ResNet and DenseNet is evaluated on a dataset including 41 major categories of food ingredients and 100 images for each category.Theoretical analysis and experimental results demonstrate that CBNet achieves promising accuracy for multi-class classification and improves the performance of convolutional neural networks. | Lili Pan Cong Li Samira Pouyanfar Rongyu Chen Yan Zhou | 2020 | Computers, Materials & Continua2020，，2： | 3 |
| 11 | Recent Advances and Applications Toward Emerging Lithium–Sulfur Batteries:Working Principles and Opportunities显示文摘Lithium–sulfur(Li-S)batteries have been considered as promising candidates for large-scale high energy density devices due to the potentially high energy density,low cost,and more pronounced ecological compatibility.However,the complex Li-S conversion reactions,unsatisfactory battery performance,and unsafe metallic Li anode restrict the development of Li-S batteries to achieve commercialization.This review mainly focuses on three aspects which are the remaining challenges,recent advances,and applications in Li-S batteries.Firstly,this review portrays Li-S conversion chemistry involving the multi-step and multi-electron reaction mechanism,as well as the remaining challenges.Then,the scientific strategies and very recent advances of the cathode,electrolyte,lithium anode,and other constituent parts of Li-S batteries are detailly summed up,as well as their advantages and limitations.For the sake of promoting the Li-S batteries practicalization,next section is primarily concerned with problems,the corresponding solutions,and application scenarios of practical pouch cells.Finally,the important findings as guidelines and some future directions as trends for developing emerging Li-S batteries are briefly summarized. | Rongyu Deng Meng Wang Huanyu Yu Shunrui Luo Jinhui Li Fulu Chu Bin Liu Feixiang Wu | 2022 | Energy & Environmental Materials2022，5，3： | 3 |
| 12 | FROST RESISTANCE OF POLYVINYL ALCOHOL FIBER REINFORCED CEMENTITIOUS COMPOSITES显示文摘This article studies the frost resistance of polyvinyl alcohol (PVA) fiber reinforced cementitious composites. The test samples contain different PVA fiber volume fractions such as 0, 0.5%, 1% and 2%. The freeze-thaw test is carried on in TDR type apparatus. The outward appearance, the weight loss factor and the relative dynamic elastic modulus are analyzed, and conclusions are drawn that PVA fibers can significantly improve the frost resistance of cementitious composites and frost resistance of PVA fiber reinforced cementitious composites with fiber volumetric fraction of 1% is better. | Jianwen Bai 1 Shuguang Liu 1 Rongyue Guo 2 Rong Xu 3 ( 1 Institute of Mining Technology, Inner Mongolia University of Technology, Hohhot 010051, China) ( 2 Testing Center of China Railway Group Six Hohhot Railway Bureau Construction CO. LTD, Hohhot 010050, China) ( 3 Civil Engineering and Architectural, Inner Mongolia Institute of Architectural Technology, Hohhot 010070, China) | 2011 | Acta Mechanica Solida Sinica2011，24，S1： | 3 |
| 13 | Effects of GM-CSF, IL-3, and GM-CSG/IL-3 fusion protein on apoptosis of human myeloid leukemic cell line Tf-1 induced by irradiation显示文摘AIM: To observe the effects of three cytokines on the apoptosis of Tf-1 cells induced by γ irradiation and investigate the relationship between apoptosis and caspase-3 activity. METHODS: Different cytokines GM-CSF, IL-3 and GM-CS/IL-3 fusion protein were added into the irradiated Tf-1 cells. MTT assay, morphology, flow cytometry,and DNA fragmentation assay were used to observe the effects of cytokines on apoptosis. The caspase-3 activity was determined with a fluorocytometer. RESULTS: Irradiated Tf-1 cells showed typical morphological characteristic of apoptosis demonstrated by transmission electron microscopy and were accumulated in G0/G1 phase. In the groups treated with growth factors after irradiation, three cytokines significantly increased the viability rate, distinctly decreased the apoptosis rate and the proportion of DNA fragmentation. When Tf-1 cells were irradiated by γ irradiation, caspase-3 activity was increased at different time points. In comparison with the control group in which no growth factor was added after the cells were irradiated, the caspase-3 activity of irradiated Tf-1 cells was significantly inhibited by addition of the above cytokines. Thirty-six hours after irradiation, in the control group,GM-CSF, IL-3, GM-CSF and IL-3 in combination, and two GM-CSF/IL-3 fusion protein groups, the apoptosis ratewas 73 %, 11%, 15 %, 13 %, 12 %, and 13 %. The percent of fragmented DNA was 36 %, 19 %, 18 %, 14 %,13 %, and 14 %. The fluorescence intensity was 16923, 5529, 6581, 5322, 5426, and 5485. CONCLUSION:GM-CSF, IL-3, and GM-CSF/IL-3 fusion protein could protect Tf-1 cells from apoptosis induced by γ irradiation.After Tf-1 cells were irradiated, the caspase-3 activity was significantly increased but was dramatically decreased by the above cytokines. The remarkable inhibition of caspase-3 activity may be one of the mechanisms of these hematopoietic growth factors exerting their anti-apoptotic effects. | Su-rongYANG LiWEN Ying-qingLU Qin-yanGONG RongYU Ming-huiYAO | 2004 | Acta Pharmacologica Sinica2004，25，1： | 3 |
| 14 | Spatial and temporal variation of phenological growing season and climate change impacts in temperate eastern China显示文摘 | XiaoqiuChen BingHu RongYu | 2005 | Global Change Biology2005，，7： | 3 |
| 15 | Genetic bases of rice grain shape: so many genes, so little known显示文摘 | Rongyu Huang Liangrong Jiang Jingsheng Zheng Tiansheng Wang Houcong Wang Yumin Huang Zonglie Hong | 2012 | Trends in Plant Science2012，，： | 2 |
| 16 | A composite insulation structure for silicon-based planar neuroprobes显示文摘Silicon-based planar neuroprobes are composed of silicon substrate,conducting layer,and insulation layers of SiO 2 or SiN membrane.The insulation layer is very important because it affects many key parameters of neuprobes,like impedance,SNR(signal noise ratio),reliability,etc.Monolayer membrane of SiO 2 or SiN are not good choices for insulation layer,since defects and residual stress in these layers can induce bad passivation.In this paper a composite insulation structure is studied,with thermal SiO 2 as the lower insulation layer and with multilayer membrane composed of PECVD SiO 2 and SiN as the upper insulation layer.This structure not only solves the problem of residual stress but also ensures a good probe passivation.So it's a good choice for insulation layer of neuroprobes. | ZHAO Hui PEI WeiHua CHEN SanYuan GUI Qiang TANG RongYu GUO Kai CHEN HongDa | 2012 | Science China(Technological Sciences)2012，55，9： | 2 |
| 17 | Green synthesis of gold nanoclusters using papayajuice for detection of L-lysine显示文摘Gold nanoclusters were rapid synthesized within 3 min at 120 ℃ by using papaya juice as a capping and reducing agent(P-AuNCs). The properties of the fluorescent probe were characterized by fluorescent spectroscopy, UV-vis spectroscopy, dynamic light scattering and transmission electron microscope.Based on the surface electron density increase-induced fluorescence enhancing principle, a high selective method for detection of L-lysine was developed with the as-prepared P-AuNCs coupling the fluorescence emission at 440 nm. The fluorescent probe showed high stability and good biocompatibility. Its fluorescence intensity was found to be linearly dependent on the L-lysine concentration in the range of 10.0μmol/L to 1000.0 μmol/L(R^2=0.969) with a limit of detection of 6.0μmol/L. Furthermore, the PAuNCs based approach was applied for monitoring the urine L-lysine contents, demonstrating great potential of fluorescent probes in real samples analysis. | Tian Yu Chengnan Xu Juan Qiao Rongyue Zhang Li Qi | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 18 | 32-site microelectrode modified with Pt black for neural recording fabricated with thin-film silicon membrane显示文摘Multi-electrode array is an important tool in the study of neural-network,cognition,remembrance,as well as brain-computer-interface,etc.Fork-like 32-site microelectrodes are developed with silicon.By use of integrated circuit technology,the length of the electrodes,the area of the recording sites,as well as the spaces between the sites are closely controlled.SiO2/SiNx/SiO2composite dielectric membrane and Pt black are introduced to improve the characteristics of the electrodes.The whole thickness of the thin-film probe was 21μm.By combining the modifying process with the micro-fabrication method,this kind of silicon based microelectrode satisfies high-density recording and the performance characterization is evaluated by test in vitro and in vivo. | CHEN SanYuan PEI WeiHua ZHAO Hui GUI Qiang TANG RongYu CHEN YuanFang FANG XiaoLei HONG Bo GAO XiaoRong CHEN HongDa | 2014 | Science China(Information Sciences)2014，57，5： | 2 |
| 19 | GLOBAL ASYMPTOTICAL STABILITY OF AN OBLIGATE LOTKA-VOLTERRA MUTUALISM MODEL显示文摘By constructing a suitable Lyapunov function,sufficient conditions which ensure the global asymptotical stability of the positive equilibrium and boundary equilibrium of an obligate Lotka-Volterra mutualism model are obtained,respectively.It is shown that the conditions which ensure the local stability of the nonnegative equilibria is enough to ensure their global asymptotical stability.Our result supplements and complements some known result. | Yuanfang Chen Rongyu Han Liya Yang Fengde Chen | 2014 | Annals of Differential Equations2014，30，3： | 2 |
| 20 | Preparation of superhydrophobic silica film on Mg–Nd–Zn–Zr magnesium alloy with enhanced corrosion resistance by combining micro-arc oxidation and sol–gel method显示文摘 | Shaohua Wang Xingwu Guo Yijun Xie Lihua Liu Haiyan Yang Rongyu Zhu Jia Gong Liming Peng Wenjiang Ding | 2012 | Surface & Coatings Technology2012，，： | 2 |
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