|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Response of commercial leghorns to sodium aluminosilicate when fed different levels and sources of available phosphorus显示文摘 | ROLAND S D RABON H FROST T | 1990 | Poultry Science1990，69，12： | 1 |
| 3 | Fatigue life improvement through surface nanostructuring of stainless steel by means of surface mechanical attrition treatment 显示文摘 | Roland T Retraint D Lu K | 2006 | Scripta Materialia2006，54，： | 1 |
| 4 | Evaluation of raw coals as fuels for direct carbon fuel cells 显示文摘 | LI X ZHU Z H ROLAND D M | 2010 | Joumal of Power Sources2010，195，13： | 1 |
| 5 | Fatigue life improvement through surface nanostructuring of stainless steel by means of surface mechanical attrition treatment显示文摘 | Roland T Retraint D Lu K | | 0，，11： | 1 |
| 6 | Improved oxidation of air pollutants in a non-thermal plasma 显示文摘 | Holzer F Kopinke F D | 2002 | Catalysis Today2002，73，34： | 1 |
| 7 | P-nitrophenol-α-glucopyramoside as substrate for measurement of maltase activity in human semen显示文摘 | Pierre C Roland R Tremblay D | 1978 | J Clin Chem1978，24，2： | 1 |
| 8 | Performance of a pi-lot-scale continuous flow microbial electrolysis cell fed winerywastewater显示文摘 | Roland D Cusick Bill Bryan Denny S Parker | 2011 | Appl Microbiol Biotechnol2011，89，： | 1 |
| 9 | CVD Diamond Windows Studied with Low and High-Power Millime-ter Waves显示文摘 | ROLAND H GUNTER D ANDREAS M | | 0，，03： | 1 |
| 10 | Performance of commercial laying hens fed various phosphorus levels, with and without supplemental phytase显示文摘 | GORDON R ROLAND S D | 1997 | Poultry Science1997，76，8： | 1 |
| 11 | Microbiology of normal external auditory canal显示文摘 | STROMAN D W ROLAND P S DOHAR J | 2001 | Laryngoscope2001，111，： | 1 |
| 12 | Body weight and semen production of broiler breeder males as influenced by crude protein levels and feeding regimens during rearing显示文摘 | MCDANIE G R ROLAND D A LIU P | 1999 | Poult Sci1999，78，2： | 1 |
| 13 | Improved Oxidation of Air Pollutants in a Non-thermal Plasma 显示文摘 | U Roland F Holzer F D Kopinke | 2002 | Catalysis Today2002，73，： | 1 |
| 14 | Improved oxidation of air pollutants in a non-thermal plasma 显示文摘 | ROLAND U HOLZER F KOPINKE F D | 2002 | Catalysis Today2002，73，： | 1 |
| 15 | Effect of core stability training on throwing velocity in female handball players显示文摘 | A H ROLAND V D T Seiler S | 2011 | J Strength Cond Res2011，25，3： | 1 |
| 16 | Energy and Exports in China 显示文摘 | Kahrl F Roland - Holst D | 2008 | China Economic Review2008，19，4： | 1 |
| 17 | A role for Lys-His-Gly-NH2 in avian and murine Bcell developmebt显示文摘 | Lassila Olli Lambris Jphn D Roland H Gisler | 1989 | Cellular Immunology1989，122，： | 1 |
| 18 | Age at sexual maturity influences the response of single comb white leghorn pullets to marginal and low levels of dietary phosphorus显示文摘 | RAO S K ROLAND D A ORBAN J I | 1995 | The Journal of Nutrition1995，125，5： | 1 |
| 19 | Classroom influence on bullying显示文摘 | Roland E Galloway D | 2002 | Educational Research2002，44，30： | 1 |
| 20 | Bispecific antibodies for cancer immunotherapy:current perspectives显示文摘 | Müller D Roland E Kontermann R | | 0，，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员