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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | Acute bleeding after argon plasma coagulation for weight regain after gastric bypass: A case report显示文摘Roux-en-Y gastric bypass(RYGB)is the most commonly performed surgical procedure used to treat obesity worldwide.Despite satisfactory results in terms of weight loss,over time many patients experience weight regain.There are many factors that contribute to weight regain after RYGB,including the diameter of the gastric-jejunal anastomosis(GJA).One of the most commonly performed endoscopic procedures for weight regain after RYGB is argon plasma coagulation(APC).We report a case of hematemesis after outlet revision with APC.We highlight several treatment modalities that can be used to treat this complication.CASE SUMMARY A 45-year-old female with a history of weight regain after RYGB was referred for possible endoscopic treatment for weight regain.On endoscopic evaluation,the diameter of the GJA was 22 mm.Due to the dilated GJA,treatment with APC was performed.Several months later she reported a return of poor satiety and an increased appetite.A repeat endoscopy was then performed.The GJA was approximately 15 mm and was incompetent.APC was performed.One day post procedure she had four episodes of hematemesis.An endoscopy was performed and a large ulcer with a visible arterial vessel was visualized at the GJA.Coagulation was attempted using a Coagrasper and after initial contact with the vessel,the vessel started oozing.Due to fibrosis and the depth of ulceration in the area,clips and repeat APC could not be used.Therefore,an attempt to inject epinephrine injection was made.However,persistent oozing was noted.As a result,hemostatic powder was applied to the region of the bleeding vessel.Subsequently,no more bleeding was observed.On follow-up,the patient remained hemodynamically stable and a second look endoscopy was not performed.The patient was discharged three days later.CONCLUSION APC revision of the GJA is known to be a relatively safe and effective strategy to manage weight regain post RYGB.Anastomotic site bleeding is an infrequent and potentially life-threatening complication associated with this therapy.Endoscopic management is the first line therapy used to achieve hemostasis in these cases. | Diogo Turiani Hourneaux de Moura Amit H Sachdev Po-Wen Lu Igor Braga Ribeiro Christopher C Thompson | 2019 | World Journal of Clinical Cases2019，7，15： | 1 |
| 4 | Trypanosoma cruzi ealreticulin: A possible role in Chagas' disease autoimmunity 显示文摘 | RIBEIRO C H LOPEZ N C RAMIREZ G A | 2009 | Molecular Immunology2009，46，6： | 1 |
| 5 | Se-quence and function of lysosomal and digestive cathepsin D-likeproteinases of Musca domestica midgut显示文摘 | PADILHA M H PIMENTEL A C RIBEIRO A F | 2009 | Insect Biochem MolBiol2009，39，11： | 1 |
| 6 | Modelling the adsorption kinetics of erythromycin onto neutral and anionic resins显示文摘 | RIBEIRO M H L RIBEIRO I A C | | 0，，： | 1 |
| 7 | Effects of the Use of Theoretical Versus Theoretical-practical Training on CPR显示文摘 | Miotto H C Camargos F R Ribeiro C V | 2010 | Arq Bras Cardiol2010，95，3： | 1 |
| 8 | Prevalence andpredictors of pulmonary embolism in patients with acutely decompensated heart failure显示文摘 | Correia LC Goes C Ribeiro H | 2012 | Arq Bras Cardiol2012，98，2： | 1 |
| 9 | Dopaminergie function and do- pamine transporter binding assessed with positron ernis~sion tomography in Parkinson disease显示文摘 | Ribeiro M J Vidaiihet M Loc'h C | 2002 | Arch Neurol2002，59，4： | 1 |
| 10 | The use of headspace solid phase microextraction for the characterization of volatile compounds in olive oil matrices显示文摘 | Ribeiro L H Freitas A M C Gomes da Silva M D R | 2008 | Talanta2008，77，1： | 1 |
| 11 | Hydrodechlorination of chlorofluorocarbons CF3-CFCl2 and CF3-CCl3 over Pd/carbon and Pd black catalysts 显示文摘 | Rioux R M Thompson C D Ribeiro F H | 2000 | Catal Today2000，62，： | 1 |
| 12 | SrTiO3 Preparation through Coprecipitation Methods显示文摘 | Jr ZOREL H E GUINESI L S RIBEIRO C A | 2000 | Mater Lett2000，42，12： | 1 |
| 13 | Characterization of metal/mould interface on investment casting of γ-TiAl显示文摘 | BARBOSA J PUGA H RIBEIRO C S TEODORO O M N D MONTEIRO A C | 2006 | International Journal of Cast Metals Research2006，19，6： | 1 |
| 14 | Resource sha- ring optimization for device-to-device communication underlaying cellular networks显示文摘 | Yu C H Doppler K Ribeiro C B | 2011 | IEEE Transactions on Wireless Communications2011，10，8： | 1 |
| 15 | Sorafenib in combination with capecitabine: an oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer 显示文摘 | Baselga J Segalla JG Roch6 H Del Giglio A Pinczowski H Ciruelos EM Filho SC G6mez P Van Eyll B Bermejo B Llombart A Garicochea B Durdn Md Hoff PM Espi6 M de Moraes AA Ribeiro RA Mathias C Gil Gil M Ojeda B Morales J Kwon Ro S Li S Costa F | 2012 | J Clin Oncol2012，30，13： | 1 |
| 16 | Asymmetric Reformatsky reaction: Application of mono- and dihydroxy carbohydrate derivatives as ehiral ligands显示文摘 | Ribeiro C M R Santos E S Jardim A H O | 2002 | Tetrahedron : Asymmetry2002，13，16： | 1 |
| 17 | Nkaml: A pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia显示文摘 | Rubnitz J E Inaba H Ribeiro R C | 2010 | Journal of Clinical Oncology2010，28，6： | 1 |
| 18 | Thermal characterization of bacterial cellulose-phosphate composite membranes显示文摘 | Barud H S Ribeiro C A Crespi M S | 2007 | J Therm Analy Calori2007，87，3： | 1 |
| 19 | Multifunctionalnanocomposites based on tetraethylenepentamine-modifiedgraphene oxide/epoxy显示文摘 | Ribeiro H Silva W M D Neves J C | 2015 | Polymer Testing2015，43，18： | 1 |
| 20 | Dopaminergic function and dopamine transporter density assessed with PET in parkinson's disease显示文摘 | Ribeiro MJ Vaughan RA Loc'h C et a | 2002 | Arch Neural2002，59，4： | 1 |
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