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| 1 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 2 | Effect of pH on the dispersability of silicon carbide powders in aqueous media显示文摘 | RAO R R ROOPA H N KANNAN T S | 1999 | Ceram Int1999，25，4： | 2 |
| 3 | A Multidimensional Trust Formation Model in B-to-C Ecommerce:A Conceptual Framework and Content Analyses of Academia/Practitioner Perspectives 显示文摘 | Kim D J Song Y I Braynov S B Rao H R | 2005 | Decision Support Systems2005，40，2： | 1 |
| 4 | Regulation of simultaneous hydrogen photoproduction during growth by pH alld glutamate in rhodobacter spharoides显示文摘 | Asikala k Ramana C H V Rao P R | 1995 | In J Hydrogen Energy1995，，20： | 1 |
| 5 | Community Intelligence and Social Media Services: A Rumor Theoretic Analysis of Tweets DuringSocial Crises显示文摘 | Oh O Agrawal M Rao H R | 2013 | MIS Quarterly2013，37，2： | 1 |
| 6 | A trust-based consumer decision-making model in electronic commerce: The role of trust, perceived risk ad their antecedents 显示文摘 | Kim D J Ferrin D L Rao H R | 2008 | Decision Support Systems2008，44，： | 1 |
| 7 | Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reas- sortment 显示文摘 | Matthijnssens J Taraporewala Z F Yang H Rao S Yuan L Cao D Hoshino Y Mertens P P Carner G R McNeal M Sestak K Van Ranst M Patton J T | 2010 | J Virol2010，84，4： | 1 |
| 8 | Two insect-resistant genes were transferred into poplar hybrid and transgenic poplar shew insect-resistance显示文摘 | RAO H Y WU N F HUANG M R | 2001 | Molecular Breeding of Woody Plants2001，7，3： | 1 |
| 9 | A modified Mann - Kendall trend test forautocorrelated data 显示文摘 | HAMED K H RAO A R | 1998 | Journal of Hydrology1998，204，： | 1 |
| 10 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 11 | Fool's gold: social proof in the initiation and abandonment of coverage by Wall Street analysts显示文摘 | RAO H GREVE H R DAVIS G F | 2001 | Administrative Science Quarter- ly2001，46，3： | 1 |
| 12 | Idiopathic infantile arterial calcification with thrombotic mieroangiopathy--a unique case 显示文摘 | Rani H Rao R Rao U | 2010 | Fetal Pediatr Pathol2010，29，6： | 1 |
| 13 | Solid state synthesis and thermal stability of HAP and HAP-β-TCP composite ceramic powders 显示文摘 | RAO R R ROOPA H N KANNNAN T S | 1997 | Journal of Materials Science1997，，8： | 1 |
| 14 | Predictive coding in the visual cortex:a functional interpretation of some extra-classical receptive-field effects 显示文摘 | RAO R P N BALLARD D H | 1999 | Nature Neuroscience1999，2，1： | 1 |
| 15 | Electro- spark coatings for enhanced performance of twist drills 显示文摘 | SOMA K R C FAISAL N H Srinivasa Rao D | 2008 | 202(9): 1 636-1 6442008，202，9： | 1 |
| 16 | Malignantpheechromecytoma chromaffin granule transmitters andresponse to treatment 显示文摘 | Rao F Keiser H R O Connor D T | 2000 | Hypertension2000，36，6： | 1 |
| 17 | Cultured ovules as models for cotton fiber development under low temperature显示文摘 | Haigler C H Rao N R Roberts E M | 1991 | Plant Physiology1991，95，： | 1 |
| 18 | Study of flow over side weirs under supercritical conditions 显示文摘 | K H V Durga Rao'C R S Pillai | 2008 | Water Resour Manage2008，22，： | 1 |
| 19 | Extent of pri- vate information disclosure on online social net- works: An exploration of Facebook mobile phone us- ers 显示文摘 | Kisekka V Bagchi-Sen S Rao H R | 2013 | Computers in Human Behavior2013，29，6： | 1 |
| 20 | The Price of Launching a New Product:Empirical Evidence on Factors Affecting the Relative Magnitude of Slotting Allowances显示文摘 | RAO A R MAHI H | 2003 | Marketing Science2003，22，2： | 1 |
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