|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus显示文摘AIM:To investigate the clinicopathologic features which predict surgical overall survival in patients with proximal gastric carcinoma involving the esophagus (PGCE).METHODS:Electronic pathology database established in the Department of Pathology of the Nanjing Drum Tower Hospital was searched for consecutive resection cases of proximal gastric carcinoma over the period from May 2004 through July 2009.Each retrieved pathology report was reviewed and the cases with tumors crossing the gastroesophageal junction line were selected as PGCE.Each tumor was re-staged,following the guidelines on esophageal adenocarcinoma,according to the 7th edition of the American Joint Commission on Cancer Staging Manual.All histology slides were studied along with the pathology report for a retrospective analysis of 13 clinicopathologic features,i.e.,age,gender,Helicobacter pylori (H.pylori ) infection,surgical modality,Siewert type,tumor Bormann's type,size,differentiation,histology type,surgical margin,lymphovascular and perineural invasion,and pathologic stage in relation to survival after surgical resection.Prognostic factors for overall survival were assessed with uniand multi-variate analyses.RESULTS:Patients' mean age was 65 years (range:47-90 years).The male:female ratio was 3.3.The 1-,3and 5-year overall survival rates were 87%,61% and 32%,respectively.By univariate analysis,age,male gender,H.pylori ,tumor Bormann's type,size,histology type,surgical modality,positive surgical margin,lymphovascular invasion,and pT stage were not predictive for overall survival;in contrast,perineural invasion (P = 0.003),poor differentiation (P = 0.0003),> 15 total lymph nodes retrieved (P = 0.008),positive lymph nodes (P = 0.001),and distant metastasis (P = 0.005) predicted poor post-operative overall survival.Celiac axis nodal metastasis was associated with significantly worse overall survival (P = 0.007).By multivariate analysis,≥ 16 positive nodes (P = 0.018),lymph node ratio > 0.2 (P = 0.003),and overall pathologic stage (P = 0.002) were independent predictors for poor overall survival after resection.CONCLUSION:Patients with PGCE showed worse overall survival in elderly,high nodal burden and advanced pathologic stage.This cancer may be more accurately staged as gastric,than esophageal,cancer. | Yi-Fen Zhang Jiong Shi Hui-Ping Yu An-Ning Feng Xiang-Shan Fan Gregory Y Lauwers Hiroshi Mashimo Jason S Gold Gang Chen Qin Huang | 2012 | World Journal of Gastroenterology2012，18，27： | 12 |
| 2 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 3 | Efficacy and safety of sorafenib in patients in the Asia Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised,double-blind, placebo controlled trial显示文摘 | Cheng A L Kang Y K Chen Z Tsao C J Qin S Kim J S | 2009 | Lancet Oncol2009，10，： | 1 |
| 4 | Feelback stabilization via designed planar centre manifold显示文摘 | DONG Y L CHENG D Z QIN H S | 2004 | International Journal of Robust and Nonlinear Control2004，14，1： | 1 |
| 5 | Finite element analysis about effects of particle morphology on mechanical response of composites显示文摘 | Chen C R Qin S Y Li S X | 2000 | Materials Science and Engineering2000，278，： | 1 |
| 6 | Fault Diagnosis of electric power systems based on fuzzy Petri Net显示文摘 | Sun J Qin S Y Song Y H | 2004 | IEEE Transactions on Power Systems2004，19，4： | 1 |
| 7 | Separation and determination of β - agonists in serum by capillary zone electrophoresis with amperometric detection 显示文摘 | T S Zhou H Qin Y Z Hui | 2001 | Analytica Chimica Acta2001，441，： | 1 |
| 8 | Structure and properties of novel electrospun tussah silk fibroin/poly (lactic acid) composite nano- fibers 显示文摘 | He J X Qin Y R Cui S Z | 2011 | J Mater Sei2011，46，9： | 1 |
| 9 | The a-chemokine, stromal cell-derived fac- tor-la, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduc- tion pathways显示文摘 | Ganju R K Brubaker S A Meyer J Dutt P Yang Y Qin S | 1998 | J Biol Chem1998，273，23： | 1 |
| 10 | Filtration Properties of Electrospinning Nanofibers显示文摘 | Qin x H Wang S Y | 2006 | Journal of Applied Polymer Science2006，102，2： | 1 |
| 11 | Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus显示文摘 | Huang S Zhao Y Qin Z | 2011 | Process Biochemistry2011，46，3： | 1 |
| 12 | Quality-relevant and process-relevant fault monitoring with concurrent projection to latent structures 显示文摘 | QIN S J ZHENG Y | 2013 | AIChE Journal2013，59，2： | 1 |
| 13 | HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPKp38 through receptor for advanced glyca- tion end products 显示文摘 | QIN Y H DAIS M TANG G S | 2009 | J Immunol2009，183，10： | 1 |
| 14 | 查看详情显示文摘 | Wang G E Qin W P Zhang J S Zhang J S Wang Y Cao C Y Wang L L Wei G D Zhu P E Wu C E Kim Ryongjin | | 0，，： | 1 |
| 15 | Experimental realization of second harmonic generation in a fibonacei optical superlatfice of LiTaOs 显示文摘 | ZHU S N ZHU Y Y QIN Y Q | 1997 | Phys Rev Lett1997，78，14： | 1 |
| 16 | Fault diagnosis ofelecaic power systems based on fuzzy petri nets显示文摘 | Sun J Qin S Y Song Y H | 2004 | IEEE Trans on Power Systems2004，19，4： | 1 |
| 17 | An efficient aerobic oxidation for p-xylene to p-toluic acid using azacrown ether-tethered Mn( III) Schiff base complexes as catalysts 显示文摘 | Zeng W Li J Z Qin S Y | 2004 | Supermole Chem2004，16，8： | 1 |
| 18 | Homogenous synthesis of hydroxyethyl cellulose in NaOH/Urea aqueous solution显示文摘 | ZHOU J P QIN Y LIU S L | 2006 | Macromol Biosci2006，6，1： | 1 |
| 19 | Finite element analysis of the clamp band joint 显示文摘 | QIN Z Y YAN S Z CHU F L | 2012 | Applied Mathematical Modelling2012，36，1： | 1 |
| 20 | The use of a carbon nanotube layer on a polyurethane rrmltifilament substrate for monitoring slratins as large as 400% 显示文摘 | Fan Q Q Qin Z Y Gao S L | 2012 | Carbon2012，50，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员