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| 1 | Active tectonic blocks and strong earthquakes in the continent of China显示文摘The primary pattern of the late Cenozoic to the present tectonic deformation of China is characterized by relative movements and interactions of tectonic blocks. Active tectonic blocks are geological units that have been separated from each other by active tectonic zones. Boundaries between blocks are the highest gradient of differential movement. Most of tectonic activity occurs on boundaries of the blocks. Earthquakes are results of abrupt releases of accumulated strain energy that reaches the threshold of strength of the earth's crust. Boundaries of tectonic blocks are the locations of most discontinuous deformation and highest gradient of stress accumulation, thus are the most likely places for strain energy accumulation and releases, and in turn, devastating earthquakes. Almost all earthquakes of magnitude greater than 8 and 80%-90% of earthquakes of magnitude over 7 occur along boundaries of active tectonic blocks. This fact indicates that differential movements and interactions of active tectonic blocks are the primary mechanism for the occurrences of devastating earthquakes. | ZHANG Peizhen (张培震) DENG Qidong (邓起东) ZHANG Guomin (张国民) MA Jin (马 瑾) GAN Weijun (甘卫军) MIN Wei (闵 伟) MAO Fengying (毛凤英) WANG Qi (王 琪) | 2003 | Science China Earth Sciences2003，46，z2： | 239 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-KB signaling pathway and activating the PI3K/Akt/Nrf2 pathway显示文摘 | Si-tong LI Qi DAI Shu-xian ZHANG Ya-jun LIU Qiu-qiong YU Fei TAN Shu-hong LU Quan WANG Jian-wen CHEN He-qing HUANG Pei-qing LIU Min LI | 2018 | Acta Pharmacologica Sinica2018，39，8： | 43 |
| 4 | Quantitative and HPLC fingerprint analysis combined with chemometrics for quality evaluation of Codonopsis Radix processed with different methods显示文摘Objective: To observe the effect of different processing methods on the quality of Codonopsis Radix and provide data reference for the reasonable processing in the producing areas.Methods: An analytical strategy that combined quantitative and HPLC fingerprint analysis with chemometrics was developed for the quality evaluation of Codonopsis Radix. Lobetyolin, polysaccharide, sucrose,glucose, and fructose were detected simultaneously in Codonopsis Radix samples treated with different processing methods including dryer-drying, sun-drying, shade-drying, sulfur fumigation, and kneading,etc.Results: The results showed that different processing methods had an obvious impact on the quality of Codonopsis Radix. Sun-drying or shade-drying was recommended, and sulfur fumigation should be avoided. And dryer-drying at 40 °C-50 °C was suggested to meet the requirement for large scale processing. In addition, based on the content of polysaccharide, glucose, and fructose, it was advised to knead for three times. As for lobetyolin and sucrose, kneading should be avoided.Conclusions: Our findings demonstrated that processing method had a big impact on the quality of Codonopsis Radix. Based on the results, the appropriate processing methods directed at different requirements were recommended. The study could lay a foundation for the reasonable processing of Codonopsis Radix in producing areas. | Shi-man Gao Jiu-shi Liu Min Wang Ting-ting Cao Yao-dong Qi Ben-gang Zhang Hai-tao Liu Xiao-bo Sun Pei-gen Xiao | 2019 | Chinese Herbal Medicines2019，11，2： | 39 |
| 5 | Contemporary crustal deformation of the Chinese continent and tectonic block model显示文摘We obtain the preliminary result of crustal deformation velocity field for the Chinese con-tinent by analyzing GPS data from the Crustal Motion Observation Network of China (CMONOC), particularly the data from the regional networks of CMONOC observed in 1999 and 2001. We de-lineate 9 tectonically active blocks and 2 broadly distributed deformation zones out of a denseGPS velocity field, and derive block motion Euler poles for the blocks and their relative motionrates. Our result reveals that there are 3 categories of deformation patterns in the Chinese conti-nent. The first category, associated with the interior of the Tibetan Plateau and the Tianshan oro-genic belt, shows broadly distributed deformation within the regions. The third category, associatedwith the Tarim Basin and the region east of the north-south seismic belt of China, shows block-likemotion, with deformation accommodated along the block boundaries only. The second category, mainly associated with the borderland of the Tibetan Plateau, such as the Qaidam, Qilian, Xining(in eastern Qinghai), and the Diamond-shaped (in western Sichuan and Yunnan) blocks, has thedeformation pattern between the first and the third, i.e. these regions appear to deform block-like,but with smaller sizes and less strength for the blocks. Based on the analysis of the lithosphericstructures and the deformation patterns of the regions above, we come to the inference that thedeformation modes of the Chinese continental crust are mainly controlled by the crustal structure.The crust of the eastern China and the Tarim Basin is mechanically strong, and its deformationtakes the form of relative motion between rigid blocks. On the other hand, the northward indentation of the Indian plate into the Asia continent has created the uplift of the Tibetan Plateau and the Tianshan Mountains, thickened their crust, and raised the temperature in the crust. The lower crust thus has become ductile, evidenced in low seismic velocity and high electric conductivity observed. The brittle part of the crust, driven by the visco-plastic flow of the lower crust, deforms extensively at all scales. The regions of the second category located at the borderland of the Tibetan Plateau are at the transition zone between the regions of the first and the third categories in terms of the crustal structure. Driven by the lateral boundary forces, their deformation style is also between the two, in the form of block motion and deformation with smaller blocks and less internal strength. | WANG Min (王 敏) SHEN Zhengkang (沈正康) NIU Zhijun (牛之俊) ZHANG Zusheng (张祖胜) SUN Hanrong (孙汉荣) GAN Weijun (甘卫军) WANG Qi (王 琪) REN Qun (任 群) | 2003 | Science China Earth Sciences2003，46，z2： | 33 |
| 6 | Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma显示文摘AIM: To investigate the expression of programmed death (PD)-1,PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC).METHODS: Liver biopsies and HCC specimens from patients were collected and histologically examined.The expression of PD-1,PD-L1,and PD-L2 in biopsy specimens of chronic hepatitis and HCC specimens was evaluated by immunohistochemical staining.The association between the expression level of PD-1,PD-L1,and PD-L2 and clinical and pathological variables was analyzed statistically.RESULTS: Expression of PD-1 was found in liverinfiltrating lymphocytes.In contrast,PD-L1 and PD-L2 were expressed in non-parenchyma liver cells and tumor cells.The expression of PD-L1 was significantly correlated with hepatitis B virus infection (1.42 ± 1.165 vs 0.50 ± 0.756,P = 0.047) and with the stage of HCC (7.50 ± 2.121 vs 1.75 ± 1.500 vs 3.00 ± 0.001,P = 0.018).PD-1 and PD-Ls were significantly up-regulated in HCC specimens (1.40 ± 1.536 vs 5.71 ± 4.051,P = 0.000;1.05 ± 1.099 vs 4.29 ± 3.885,P = 0.004;1.80 ± 1.473 vs 3.81 ± 3.400,P = 0.020).CONCLUSION: PD-L1 may contribute to negative regulation of the immune response in chronic hepatitis B.PD-1 and PD-Ls may play a role in immune evasion of tumors. | Bao-Ju Wang Jun-Jie Bao Jun-ZhongWang Yang Wang Min Jiang Ming-You Xing Wan-Guang Zhang Jun-Ying Qi Michael Roggendorf Meng-Ji Lu Dong-Liang Yang | 2011 | World Journal of Gastroenterology2011，17，28： | 32 |
| 7 | Clinical short-term results of radiofrequency ablation in liver cancers显示文摘AIM: To study local therapeutic efficacy, side effects, andcomplications of radiofrequency ablation (RFA), whichis emerging as a new method for the treatment ofpatients with hepatocellular carcinoma (HCC) withcirrhosis or chronic hepatitis and metastatic liver cancer.METHODS: Thirty-six patients with primary andsecondary liver cancers (21 with primaryhepatocellular carcinoma, 12 with colorectal cancerliver metastases and 3 with other malignant livermetastases), which were considered not suitable forcurative resection, were include in this study. Theywere treated either with RFA (RITA2000, MountainView, California, USA) percutaneously (n=20)orintraoperatively (n=16).The procedures wereperformed using the ultrasound guidance. The qualityof RFA were based on monitoring of equipments andsubject feeling of the practitioners. Patients treatedwith RFA was followed according to clinical findings,radiographic images, and tumor markers.RESULTS: Thirty-six patients underwent RFA for 48nodules. RFA was used to treat an average 1.3 lesionsper patient, and the median size of treated lesions was2.5 cm (range, 0.5-9 cm). The average hospital staywas 5.6 days overall (2.8 days for percutaneous casesand 7.9 days for open operations). Seven patientsunderwent a second RFA procedure (sequentialablations). Sixteen HCC patients with a high level ofalpha fetoprotein (AFP) and 9 colorectal cancer livermetastases patients with a high level of serumcarcinoembryonic antigen (CEA) have a great reductionbenefited from RFA. Four (11.1 %) patients hadcomplications: one skin burn; one postoperativehemorrhage; one cholecystitis and one hepatic abscessassociated with percutaneous ablations of a largelesion. There were 4 deaths: 3 patients died from localand system diseases (1 at 7 month, 1 at 9 month, and 1at 12 month), 1 patients died from cardiovascular shock,but no RFA-related death. At a median follow-up of 10months (range, 1-24 months), 6 patients (16.7 %) hadrecurrences at an RFA site, and 20 patients (56.7 %)remained clinically free of disease.CONCLUSION: RF ablation appears to be an effective,safe, and relatively simple procedure for the treatmentof unresectable liver cancers. The rate and severity ofcomplications appear acceptable. However, furtherstudy is necessary to assess combination with othertherapies, long-term recurrence rates and effect onoverall survival. | Hong-Chi Jiang Lian-Xin Liu Da-Xun Piao Jun Xu An-Long Zhu Wei-Hui Zhang Lin-Feng Wu Department of Surgery,the First Clinical College,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Min Zheng Department of Ultrasound Diagnosis,the First Clinical College,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Shu-Yi Qi Second Inpatient Department,the First Clinical College,Harbin Medical University,Harbin 150001,Heilongjiang Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 33 |
| 8 | Comparison of bacterial community structures in two systems of a sewage treatment plant using PCR-DGGE analysis显示文摘The combination of PCR amplification of 16S rRNA genes with denaturing gradient gel electrophoresis (DGGE) analysis was used to reveal the compositions and dynamics of bacterial communities in a sewage treatment plant with two systems, i.e., an anoxic- anaerobic-aerobic system (inverted A2O) and an anaerobic-anoxic-aerobic one (conventional A2O) over a period from February to July 2009, during which both systems experienced serious sludge bulking problems. The DGGE patterns showed that there were many common bands in both systems, suggesting the high similarity of bacterial communities of the two systems. Meanwhile, the moving window correlation analysis showed that the two systems experienced different microbial community structure changes during the period, which might be related with the different situations of the occurrence and disappearance of sludge bulking, as being reflected by sludge volume index (SVI) values. Major bands of DGGE patterns of sludge samples were further sequenced. Phylogenetic affiliation indicated that the majority of the sequences obtained were affiliated with Actinobacteria, Firmicutes, Bacteroidetes/Chlorobi group and α- and β-Proteobacteria. Two sequences showed high similarities to typical filamentous bacteria Microthrix parvicella and Nostocoida limicola I, indicating that these bacterial species have been involved in the sludge bulking problems. | Abd El-Latif Hesham Rong Qi Min Yang | 2011 | Journal of Environmental Sciences2011，23，12： | 25 |
| 9 | Enhanced recovery after surgery protocols in functional endoscopic sinus surgery for patients with chronic rhinosinusitis with nasal polyps: a randomized clinical trial显示文摘Background:Enhanced recovery after surgery (ERAS) protocols are a series of perioperative care to optimize preoperative preparation, prevent postoperative complications, minimize stress, and speed up recovery. This study aimed to assess the impact of ERAS protocols for functional endoscopic sinus surgery (FESS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).Methods:One hundred and two patients with CRSwNP undergoing FESS were randomly divided into the ERAS group and the control group. The outcomes of the Self-Rating Anxiety Scale (SAS), Visual Analogue Scale (VAS), Medical Outcomes Study Sleep Scale (MOS-SS) and Kolcaba Comfort Scale Questionnaire (GCQ) were determined in both groups. The serum levels of C-reactive protein (CRP) were compared preoperatively and 24 hours postoperatively.Results:The ERAS group had a significantly better SAS scores than did the control group (28 [24, 35] vs. 43 [42, 47], Z=5.968, P<0.001). The rhinalgia and headache scores at 2, 24 and 48 hours postoperatively were lower in the ERAS group than that in the control group (all P < 0.001). The outcomes of the MOS-SS (43 [42, 39] vs. 28 [22, 35], Z= 7.071, P < 0.001) and GCQ (76 [68, 87] vs. 64 [50, 75], Z= 4.806, P < 0.001) were significantly different between the two groups. No significant difference was found in the preoperative CRP levels between the two groups (1.3 [0.6, 2.8] vs. 0.5 [0.5, 1.2], Z = 3.049, P > 0.05);However, the CRP level in 24 hours postoperatively was significantly lower in the ERAS group than that in the control group (2.5 [1.4, 3.9] vs. 6.6 [3.8, 9.0], Z = 5.027, P < 0.001). The incidence rates of complications, such as nausea/emesis (χ^2=0.343, P>0.05), hemorrhage, aspiration and tumble, were not increased in the ERAS group compared with those in the control group. The ERAS group had a significantly shorter length of hospital stay (5 [4, 5] days vs. 8 [8,9] days, Z=8.939, P<0.001) and hospitalization expenses ($ 2670 [2375, 2740] vs. $3129 [3116, 3456], Z=8.514, P<0.001).Conclusions:ERAS protocols might optimize FESS for patients with CRSwNP by reducing psychological and physical stress, shortening the length of hospital stay and lowering hospitalization expenses without increasing postoperative complications. | Xi-Fu Wu Wei-Feng Kong Wei-Hao Wang Lian-Xiong Yuan Hui-Qing Xu Min Qi Shao-Li Zhou Qin-Tai Yang | 2019 | Chinese Medical Journal2019，，3： | 26 |
| 10 | A national report from China Liver Transplant Registry: steroid avoidance after liver transplantation for hepatocellular carcinoma显示文摘Objective:We aimed to evaluate the efficacy and safety of steroid-free immunosuppression after liver transplantation(LT)for hepatocellular carcinoma(HCC).Methods:We retrospectively analyzed HCC recipients without steroids after LT(SF group,n=368)based on the China Liver Transplant Registry(CLTR)database.These recipients were matched 1:2 with patients using steroids(S group,n=736)for the same period after LT for HCC,according to propensity scores.Results:Multivariate analysis indicates that recipients with younger age[odds ratio(OR),1.053;P=0.011],preoperative hepatitis B virus(HBV)DNA≥1,000 copies/mL(OR,2.597;P=0.004)and beyond Milan criteria(OR,4.255;P<0.001)were identified as the risk factors associated with tumor recurrence in steroid avoidance recipients after LT.The patients fulfilling the Milan criteria in the SF group presented higher overall and tumor-free survival rates than those in the S group(P<0.05).Multivariate analysis revealed that recipient beyond Milan criteria was an independent prognostic factor for overall survival(OR,1.690;P<0.001)and tumor-free survival(OR,2.066;P<0.001).The incidences of new-onset diabetes mellitus(21.20% vs.33.29%,P<0.001),new-onset hypertension(10.05%vs.18.61%,P<0.001)and hyperlipidemia(4.08% vs.7.20%,P=0.042)were significantly lower in the SF group.Conclusions:Steroid-free immunosuppression could be safe and feasible for HBV-related HCC patients in LT.Age,HBV DNA level and Milan criteria maybe risk factors associated with tumor recurrence in steroid avoidance recipients.Recipient beyond Milan criteria was an independent prognostic factor and recipient fulfilling Milan criteria can benefit the most from steroid-free immunosuppression. | Qiang Wei Feng Gao Runzhou Zhuang Qi Ling Qinghong Ke Jian Wu Tian Shen Mangli Zhang Min Zhang Xiao Xu Shusen Zheng | 2017 | Chinese Journal of Cancer Research2017，29，5： | 25 |
| 11 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 12 | Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line显示文摘曙光 A kinase, serine/threonine 蛋白质 kinase,是潜在的 oncogene。扩大并且在人的肿瘤的几种类型在曙光 A 的表示上被发现了,包括的食道的有鳞的房间癌(ESCC ) 。在表示曙光 A 上的房间对导致 cisplatin 的 apoptosis 更抵抗,这被表明了。然而,调停的分子的机制这些效果仍然保持大部分未知。在这份报告,我们证明在通过在人的 ESCC KYSE150 的 pEGFP-Aurora-A 的稳定的 transfection 的曙光 A 的表示上,房间显著地支持了房间增长并且禁止了 cisplatin- 或紫外导致照耀的 apoptosis。caspase-3 并且 poly 的劈开(自动数据处理核糖) 在在表示房间上的曙光 A 的聚合酶(PARP ) 实质地在 cisplatin 或紫外处理以后被减少。而且,我们发现有 siRNA 的内长的曙光 A kinase 的那 silencing 实质地提高了敏感到导致 cisplatin 或在人的 ESCC EC9706 房间的紫外导致 apoptosis。在平行,在曙光 A 的表示上 potently 起来调整了 Bcl-2 的表示。而且,由废除的 siRNA 的 Bcl-2 击倒 Aurora-A 禁止 apoptosis 上的效果。总起来说,这些数据提供证据在支持房间增长并且禁止 apoptosis 的表示上的那曙光 A,建议是的新奇机制仔细与恶意的显型和 ESCC 房间的反癌症药抵抗有关。 | Xiao Xia Wang Rong Liu Shun Qian Jin Fei Yue Fan Qi Min Zhan | 2006 | Cell Research2006，16，4： | 24 |
| 13 | Use of the Metabolomics Approach to Characterize Chinese Medicinal Material Huangqi显示文摘基因、新陈代谢的采指纹的罐头的集成提供一条新途径区分类似的繁体中文医药(TCM ) 材料。二豆科的植物, Mojia Huangqi 和 Menggu Huangqi,是在形态学,化学成分,和 genomic DNA 顺序的重要医药植物和份额伟人类似。Mojia Huangqi 和 Menggu Huangqi 的分类为超过 50years 被辩论了, TCM 材料的辨别直接影响药理学和临床的效果。AFLP 基于新陈代谢的采指纹的基因采指纹和 GCTOF/MS-based 被用来成功地区别二种。AFLP 的结果支持了 Menggu Huangqi 是 Mojia Huangqi 的变体的意见。新陈代谢的采指纹证明生长地点比遗传型在代谢物作文和数量上有更大的影响(栽培对野) 在 Menggu Huangqi。一些可溶的糖,丰满的酸,脯氨酸,和 polyamine 的差别反映了植物改编到不同生长环境。用 multivariate 和 univariate,统计分析,三个 AFLP 标记和八代谢物作为候选人 DNA 和新陈代谢的标记被识别区分二植物材料。在 AFLP 标记和代谢物之间的关联网络揭示了一个复杂关联网络,它显示了特殊新陈代谢的小径和 Huangqi 的规定网络。 | Li-Xin Duan Tian-Lu Chen Ming Li Min Chen Ye-Qing Zhou Guang-Hong Cui Ai-Hua Zhao Wei Jia Lu-Qi Huang Xiaoquan Qi | 2012 | Molecular Plant2012，5，2： | 19 |
| 14 | Effect of Bufei granule on stable chronic obstructive pulmonary disease: a randomized, double blinded, placebo-controlled, and multicenter clinical study显示文摘OBJECTIVE: To study the therapeutic effect Bufei granule, which is a traditional Chinese drug that can enhance the immune function of the lung, on patients with stable chronic obstructive pulmonary disease(COPD).METHODS: This is a randomized, double blinded,placebo-controlled, and multicenter clinical study.Three medical centers in Tianjin, China, participated in the trial. A total of 140 patients with stable COPD were enrolled and randomized into two groups, with 70 patients in each. The treatment group was treated with Bufei granule, while the control group received Bufei placebo. The pharmacological treatment lasted for 12 weeks from the date of enrollment. Then, the indexes of patients were observed. Data were analyzed to study the effect of Bufei granule, with the frequency of acute exacerbation as the primary outcome. Traditional Chinese Medicine syndromes,Modified British Medical Research Council dyspnea scale score, St.George's respiratory questionnaire scores, pulmonary function, and serum inflammatory marker levels [including interleukin-6(IL-6), interleukin-8, tumor necrosis factor-α, and transformation growth factor-β1]were the secondary outcomes.RESULTS: During the 12-week treatment, treatment and control groups had no adverse reactions.The analysis of the indexes obtained from all patients showed that the therapeutic effect in the treatment group was significantly better than that in the control group because most of the similar probabilities of primary and secondary outcomes were less than 0.05,except for the level of IL-6.CONCLUSION: Bufei granule can treat patients with stable COPD by lowering the frequency of acute exacerbation, improving the quality of life,and alleviating the severity of inflammation. | Sijia Guo Zengtao Sun Enshun Liu Jihong Feng Min Fu Yuechuan Li Qi Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 19 |
| 15 | Hierarchical graphene foam-based phase change materials with enhanced thermal conductivity and shape stability for efficient solar-to-thermal energy conversion and storage显示文摘最近, graphene 泡沫(GF ) 与一三维(3D ) 互连指导模板的化学蒸汽免职(CVD ) 生产的网络被用来与提高的热电导率准备合成阶段变化材料(脉冲编码调制) 。然而, GF 的毛孔尺寸象几百测微计一样大,导致为从在到 GF 神气墙的大毛孔内的 PCM 的热转移的一个显著热电阻。在这研究,新奇 3D 层次 GF (HGF ) 被用空 graphene 网络填满 GF 的毛孔获得。HGF 然后被用来准备基于的石蜡蜡(PW ) 合成脉冲编码调制。PW/HGF 合成脉冲编码调制的热传导性分别地比 PW/GF 合成脉冲编码调制和纯 PW 的高是 87% 和 744% 。PW/HGF 合成脉冲编码调制也与在 100 次骑车比 PW/GF 合成脉冲编码调制,在阶段变化温度的可以忽略的变化,是 95% 纯 PW 的高热的精力存储密度,好热可靠性,和化学稳定性展出更好的形状稳定性。更重要地, PW/HGF 合成脉冲编码调制与高 light-to-thermal 精力变换和存储效率允许光驱动的热精力存储,显示它为在太阳能的利用和存储的应用的大潜力。 | Guoqiang Qi Jie Yang Ruiying Bao Dongyun Xia Min Cao Wei Yang Mingbo Yang Dacheng Wei | 2017 | Nano Research2017，10，3： | 18 |
| 16 | Movement and strain conditions of active blocks in the Chinese mainland显示文摘The definition of active block is given from the angles of crustal deformation and strain. The movement and strain parameters of active blocks are estimated according to the unified velocity field composed of the velocities at 1598 GPS stations obtained from GPS measurements carried out in the past years in the Chinese mainland and the surrounding areas. The movement and strain conditions of the blocks are analyzed. The active blocks in the Chinese mainland have a consistent E-trending movement component, but its N and S components are not consistent. The blocks in the western part have a consistent N-trending movement and the blocks in the eastern part have a consistent S-trending movement. In the area to the east of 90°E, that is the area from Himalayas block towards NE, the movement direction of the blocks rotates clockwisely and the movement rates of the blocks are different. Generally, the movement rate is large in the west and south and small in the east and north with a difference of 3 to 4 times between the rates in the west and east. The distributions of principal compressive strain directions of the blocks are also different. The principal strain of the blocks located to the west of 90oE is basically in the SN direction, the principal compressive strain of the blocks in the northeastern part of Qingzang plateau is roughly in the NE direction and the direction of principal compressive strain of the blocks in the southeastern part of Qingzang plateau rounds clockwisely the east end of Himalayas structure. In addition, the principal strain and shear strain rates of the blocks are also different. The Himalayas and Tianshan blocks have the largest principal compressive strain and the maximum shear strain rate. Then, Lhasa, Qiangtang, Southwest Yunnan (SW Yunnan), Qilian and Sichuan-Yunan (Chuan-Dian) blocks followed. The strain rate of the blocks in the eastern part is smaller. The estimation based on the stain condition indicates that Himalayas block is still the area with the most intensive tectonic activity and it shortens in the NS direction at the rate of 15.2±1.5 mm/a. Tianshan block ranks the second and it shortens in the NS direction at the rate of 10.1±0.9 mm/a. At present, the two blocks are still uprising. It can be seen from superficial strain that the Chinese mainland is predominated by superficial expansion. Almost the total area in the eastern part of the Chinese mainland is expanded, while in the western part, the superficial compression and expansion are alternatively distributed from the south to the north. In the Chinese mainland, most EW-trending or proximate EW-trending faults have the left-lateral or left-lateral strike-slip relative movements along both sides, and most NS-trending faults have the right-lateral or right-lateral strike-slip relative movements along both sides. According to the data from GPS measurements the left-lateral strike-slip rate is 4.8±1.3 mm/a in the central part of Altun fault and 9.8±2.2 mm/a on Xianshuihe fault. The movement of the fault along the block boundary has provided the condition for block movement, so the movements of the block and its boundary are consistent, but the movement levels of the blocks are different. The statistic results indicate that the relative movement between most blocks is quite significant, which proves that active blocks exist. Himalayas, Tianshan, Qiangtang and SW Yunnan blocks have the most intensive movement; China-Mongolia, China-Korea (China-Korea), Alxa and South China blocks are rather stable. The mutual action of India, Pacific and Philippine Sea plates versus Eurasia plate is the principal driving force to the block movement in the Chinese mainland. Under the NNE-trending intensive press from India plate, the crustal matter of Qingzang plateau moves to the NNE and NE directions, then is hindered by the blocks located in the northern, northeastern and eastern parts. The crustal matter moves towards the Indian Ocean by the southeastern part of the plateau. | LI Yanxing (李延兴) YANG Guohua (杨国华) LI Zhi (李 智) GUO Liangqian (郭良迁) HUANG Cheng (黄珹) ZHU Wenyao (朱文耀) FU Yang (符 养) WANG Qi (王 琪) JIANG Zaisen (江在森) WANG Min (王 敏) | 2003 | Science China Earth Sciences2003，46，z2： | 17 |
| 17 | Association of Cytokines with Alanine Aminotransferase, Hepatitis B Virus Surface Antigen and Hepatitis B Envelope Antigen Levels in Chronic Hepatitis B显示文摘 | Ming-Hui Li Yao Lu Lu Zhang Xing-Yue Wang Chong-Ping Ran Hong-Xiao Hao Dan Zhang Xiao-Jing Qu Ge Shen Shu-Ling Wu Wei-Hua Cao Tian-Lin Qi Ru-Yu Liu Lei-Ping Hu Min Chang Wen-Hao Hua Shun-Ai Liu Gang Wan Yao Xie | 2018 | Chinese Medical Journal2018，，15： | 17 |
| 18 | Geometry and tectonic deformation of the seismogenic structure for the 8 August 2017 M_S 7.0 Jiuzhaigou earthquake sequence,northern Sichuan, China显示文摘To reveal the geometry of the seismogenic structure of the Aug. 8, 2017 M_S 7.0 Jiuzhaigou earthquake in northern Sichuan,data from the regional seismic network from the time of the main event to Oct. 31, 2017 were used to relocate the earthquake sequence by the tomoDD program, and the focal mechanism solutions and centroid depths of the M_L ≥ 3.5 events in the sequence were determined using the CAP waveform inversion method. Further, the segmental tectonic deformation characteristics of the seismogenic faults were analyzed preliminarily by using strain rosettes and areal strains(As). The results indicate:(1) The relocated M_S 7.0 Jiuzhaigou earthquake sequence displays a narrow ~ 38 km long NNW-SSE-trending zone between the NW-striking Tazang Fault and the nearly NSstriking Minjiang Fault, two branches of the East Kunlun Fault Zone. The spatial distribution of the sequence is narrow and deep for the southern segment, and relatively wide and shallow for the northern segment. The initial rupture depth of the mainshock is 12.5 km, the dominant depth range of the aftershock sequence is between 0 and 10 km with an average depth of 6.7 km. The mainshock epicenter is located in the middle of the aftershock region, showing a bilateral rupture behavior. The centroid depths of 32 M_L ≥ 3.5 events range from 3 to 12 km with a mean of about 7.3 km, consistent with the predominant focal depth of the whole sequence.(2) The geometric structure of the seismogenic fault on the southern section of the aftershock area(south of the mainshock) is relatively simple, with overall strike of ~150° and dip angle ~75°, but the dip angle and dip-orientation exhibit some variation along the segment. The seismogenic structure on the northern segment is more complicated; several faults, including the Minjiang Fault, may be responsible for the aftershock activities. The overall strike of this section is ~159° and dip angle is ~59°, illustrating a certain clockwise rotation and a smaller dip angle than the southern segment. The differences between the two segments demonstrate variation of the geometric structure along the seismogenic faults.(3) The focal mechanism solutions of 32 M_L ≥ 3.5 events in the earthquake sequence have obvious segmental characteristics. Strike-slip earthquakes are dominant on the southern segment, while 50% of events on the northern segment are thrusting and oblique thrusting earthquakes, revealing significant differences in the kinematic features of the seismogenic faults between the two segments.(4) The strain rosettes for the mainshock and the entire sequence of 31 M_L ≥ 3.5 aftershocks correspond to strike-slip type with NWW-SEE compressional white lobes and NNE-SSW extensional black lobes of nearly similar size. The strain rosette and As value of the entire sequence of 22 M_L ≥ 3.5 events on the southern segment are the same as those of the M_S 7.0 mainshock,indicating that the tectonic deformation here is strike-slip. However, the strain rosette of the entire sequence of 10 M_L ≥ 3.5 events on the northern segment show prominent white compressional lobes and small black extensional lobes, and the related As value is up to 0.52,indicating that the tectonic deformation of this segment is oblique thrusting with a certain strike-slip component. Differences between the two segments all reveal distinctly obvious segmental characteristics of the tectonic deformation of the seismogenic faults for the Jiuzhaigou earthquake sequence. | Feng Long GuiXi Yi SiWei Wang YuPing Qi Min Zhao | 2019 | Earth and Planetary Physics2019，3，3： | 17 |
| 19 | Detection,isolation,and identification of cadmium-resistant bacteria based on PCR-DGGE显示文摘这研究集中于从跟踪的 Pb-Zn 屏蔽镉抵抗的菌株。我们调查了微生物引起的社区住在 Dong-san-cha Pb-Zn 在中国北京跟踪的差异,由聚合酶链菌株的 16S rRNA 基因的使中毒反应的坡度胶化电气泳动(DGGE ) ,并且在 DGGE 侧面发现二主导的紧张。用特殊文化媒介,我们孤立二强壮的镉抵抗的菌株。根据定序的词法、生理、生物化学的特征, BIOLOG,和 16S rDNA,二紧张作为杆菌仙影拳和 Enterobacter 下水道被识别。为细菌的重金属的最小的禁止的集中(MIC ) 是坚定的。E。下水道比 B 为重金属和抗菌素抵抗的一个更大的范围显示出更高的 MIC 价值。仙影拳。 | HU Qing DOU Min-na QI Hong-yan XIE Xiang-ming ZHUANG Guo-qiang YANG Min | 2007 | Journal of Environmental Sciences2007，19，9： | 16 |
| 20 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
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