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| 1 | Effects of Chinese herbs on multiple ion channels in isolated ventricular myocytes显示文摘背景 Shensong Yangxin (SSYX ) 是中国 materia medica 的复合配方之一。这研究被进行在钠电流( INa )上调查 SSYX 的效果,L类型钙电流(集成通信适配器, L ),短暂的外面的钾电流( Ito ),推迟的整流器电流( IK ),并且在孤立的室的 myocytes.Methods 全部房间补丁夹钳技术的里面的整流器钾水流( IK1 )被用来在酶地孤立的畿尼猪或老鼠学习离子隧道水流室的 myocytes.Results SSYX 减少了山峰 INa 由( 44.84 ??潦?华??千?潃据畬楳湯?敆慭敬瀠瑡敩瑮?楷桴?千眠牥? | LI Ning MA Ke-juan WU Xiang-feng SUN Qi ZHANG Yi-hui PU Jie-lin | 2007 | Chinese Medical Journal2007，，12： | 30 |
| 2 | Electrophysiological effects of Chinese medicine Shen song Yang xin (SSYX) on Chinese miniature swine heart and isolated guinea pig ventricular myocytes显示文摘背景沈歌杨 xin (SSYX ) 是有增加心率(HR ) 的效果的中国药的混合物。这研究试图在心和细胞的层次评估它的 electrophysiological 性质。中国缩小的猪随机被分到二个组的方法,与 SSYX 或安慰剂管理了 4 个星期(n=8 每组) 。心脏的 electrophysiological 学习(EPS ) 在药管理前后被执行。畿尼猪室的 myocytes 酶地被孤立,整个房间电压夹钳技术被用来在心脏的行动潜力(AP ) 上评估 SSYX 的效果。结果 SSYX 处理加速了 HR 从(141. | FENG Li GONG Jing JIN Zhen-yi LI Ning SUN Li-ping WU Yi-ling PU Jie-lin | 2009 | Chinese Medical Journal2009，，13： | 28 |
| 3 | Nickel-exposed Workers in China: A Cohort Study显示文摘There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a | BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying | 2014 | Biomedical and Environmental Sciences2014，27，3： | 20 |
| 4 | Modulation of KCNQ1 current by atrial fibrillation-associated KCNE4 (145E/D) gene polymorphism显示文摘背景 Atrial 纤维性颤动是有多因素的致病的普通心律不齐。最近,在在 KCNE4 基因的位置 1057 点的单个核苷酸多型性( G/T ),导致 glutamic 酸( Glu , E ) /aspartic 酸(毒蛇, D )在位置 145 KCNE4 肽点的替换,在我们与自发的 atrial 纤维性颤动(与 KCNE4 145D 更经常的 atrial 纤维性颤动)要联系的实验室被发现。然而, KCNE4 145E/Dpolymorphism 的功能的效果仍然是我们构造了的 unknown.Methods KCNE4 (145E/D ) 表示 plasmids 并且短暂地 co-transfected 他们与进中国仓鼠 ovary-K1 房间并且识别单个核苷酸多型性的可能的功能的后果的执行整个房间的夹钳补丁的记录的 KCNQ1 基因。量的数据被学生的 t 测试分析。不到 0.05 被认为统计上重要的概率价值。结果 A 慢慢地激活的、非使 \O 失去活性的电压依赖者电流((24.0 畯汢? 慨湲獥? | MA Ke-juan LI Ning TENG Si-yong ZHANG Yin-hui SUN Qi GU Dong-feng PU Jie-lin | 2007 | Chinese Medical Journal2007，，2： | 9 |
| 5 | Effects of Shensong Yangxin capsule on pacemaker channels encoded by human HCN4 gene显示文摘 | SUN Li-ping LI Ning WU Yi-ling PU Jie-lin | 2010 | Chinese Medical Journal2010，，21： | 6 |
| 6 | Clinical study of 39 Chinese patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy显示文摘在那里的背景是有 arrhythmogenic 的中国病人的临床的侧面上的很少研究恰好室的发育异常 / 心肌症(ARVD/C ) 。这研究的目的是从中国描述 ARVD/C 病人的临床的特征,到特别地定义心动电流描记器和治疗 outcomes.Methods 的特征从 1998 ~ 2006 在 Fu Wai 心血管的医院里就医的 39 个病人被包括。数据从医药档案和 33 是的这些病人的后续 records.Results 被获得男性和 6 女性(在第一个演讲的年龄是(34. | MA Ke-juan LI Ning WANG Hong-tao CHU Jian-min FANG Pi-hua YAO Yan MA Jian HUA Wei ZHANG Shu WANG Fang-zheng Li Zhang PU Jie-lin | 2009 | Chinese Medical Journal2009，，10： | 6 |
| 7 | Biogeographic characteristics of Zhesi brachiopod fauna and reconstruction of tectonopaleogeography of Jiamusi-Mongolia Block显示文摘The Kungurian-Capitanian ( Permian) Zhesi branchiopod fauna is mainly composed of cold-water typed taxa with high diversity and abundance. This fauna is similar with the coeval brachiopod faunas from Timan-Pechora,Svalbard,and Queen Elizabeth Islands of the Boreal Realm,with no real'warm-water'species. Zhesi brachiopod fauna is a cold-water fauna and should be assigned to the Boreal Realm. Considering the paleogeographic characteristics of this fauna and the basic rationale of paleobiogeographic provinces being controlled by latitude-temperate,and that the above areas were located at 50°N 70°N in the global paleoclimate reconstruction map compiled by Boucot et al. ,the paleo-latitude of the southern margin of Jiamusi-Mongolia Block,where developed the Zhesi brachiopod fauna,is suggested ranging from 40°N to 60°N. Zhesi brachiopod fauna is an endemic fauna,containing more than 75% endemic species and self-grouped as a biogeographic province,termed Inner Mongolia Province. These characteristics indicate that this area was closed or semiclosed at that time. On the Jiamusi-Mongolia Block,the Herlen-Jiamusi Old-land as an obvious 'continental barrier'hindered the northward migration of the Zhesi brachiopod fauna and the immigration of brachiopod species from other areas. The Tarim plate has collided with the Kazakhstan plate and the western part of South Tianshan-Beishan-Xar Moron Ocean has been closed. At the same time,the western margin of Jiamusi-Mongolia Block was joined with the Tarim plate. The Xar Moron Ocean in south of Jiamusi-Mongolia Block was wide enough and the ocean temperature rose gradually southward,so that it is not suitable for the cold-water brachiopods to survive and thrive on the northern margin of the North China plate. Thus,the ocean with large width and high temperature formed another natural barrier for the southward migration of the cold-water brachiopods. | WANG Chengwen LI Ning ZONG Pu | 2012 | Global Geology2012，15，2： | 6 |
| 8 | The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats显示文摘Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other vital organs [1] . However, few studies | BAI Ya Na MA Li WANG Qiu Ying PU Hong Quan ZHANG Xiao Pei WU Xi Jiang XUAN Xiao Qiang CHENG Ning | 2013 | Biomedical and Environmental Sciences2013，26，7： | 5 |
| 9 | Prevalence of Metabolic Syndrome in Chinese Nickel-exposed Workers显示文摘The prevalence of metabolic syndrome(MS was investigated in Chinese nickel-exposed workers A total of 35 104 subjects were enrolled in this study.The age-adjusted prevalence of MS,BMI≥25diabetes,hypertension,and abnormal lipid was13.9%,29.5%,12.8%,27.5%,and 47.1%respectively.The prevalence of BMI≥25hyperglycemia,and hypertension increased | YANG Ai Min BAI Ya Na PU Hong Quan ZHENG Tong Zhang CHENG Ning LI Juan Sheng LI Hai Yan ZHANG Ya Wei DING Jiao SU Hui REN Xiao Wei HU Xiao Bin | 2014 | Biomedical and Environmental Sciences2014，27，6： | 5 |
| 10 | Detection of the Urinary Biomarkers PYD, CTX-Ⅱ, and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China显示文摘Kashin-Beck disease(KBD) is an endemic degenerative osteoarthropathy of uncertain etiology. The aim of our study was to identify changes in C-telopeptide of type Ⅱ collagen(CTX-Ⅱ), pyridinoline(PYD), and deoxypyridinoline(DPD) among KBD patients. 54 KBD patients and 78 healthy controls were included this study. Urinary samples were collected and measured by ELISA. The median quantities of PYD, CTX-Ⅱ, and DPD of KBD patients were 1107.73 ng/μmol.cre, 695.11 ng/μmol.cre, and 1342.34 pml/μmol.cre, while the median quantities of healthy controls were 805.59 ng/μmol.cre, 546.47 ng/μmol.cre, and 718.15 pml/μmol.cre, respectively. The differences between KBD patients and healthy controls were statistically significant(Z = 4.405, 3.653, and 3.724; P < 0.001). The higher levels of PYD, CTX-Ⅱ, and DPD detected in KBD patients indicate that they could be used as biomarkers of KBD. | ZHAO Zhi Jun PU Guang Lan ZHAN Pei Zhen LI Qiang WU Chun Ning WANG Li Hua | 2017 | Biomedical and Environmental Sciences2017，30，5： | 5 |
| 11 | The effects of paeoniflorin monomer of a Chinese herb on cardiac ion channels显示文摘背景因为当前的 antiarrhythmic 药的潜在的 proarrhythmic 效果,发现更安全的 antiarrhythmic 药世界范围仍然是合乎需要的。Paeoniflorin 是在许多离子隧道上有不同效果的中国植物单体之一。现在的学习试图在心脏的离子 channels.Methods 上决定 paeoniflorin 的效果整个房间的补丁夹钳技术被用来记录离子隧道水流。L类型钙电流( /Ca-L ),里面的整流器钾水流( /K1 ),和短暂的外面的钾电流( /to1 )在老鼠被学习室的 myocytes 和钠电流( /Na ),慢推迟的整流器电流( /Ks ),并且 HERG 电流( /Kr )在 transfected 被调查人的胚胎的肾 293 cells.Results 100 mol/L paeoniflorin 在测试潜力在 40.29 减少了山峰 /ca-L ???螜?螜? | WANG Rong-rong LI Ning ZHANG Yin-hui RAN Yu-qin PU Jie-lin | 2011 | Chinese Medical Journal2011，，19： | 5 |
| 12 | Coevolution of brachiopod paleobiogeography and tectonopaleogeography during the late Paleozoic in Central Asia显示文摘Patterns of brachiopod paleobiogeographic regionalization in Central Asia reveal a coevolution between brachiopod paleobiogeography and tectonopaleogeography during the Early Devonian,Early Carboniferous,Late Carboniferous,Early Permian,and Middle Permian.The coevolutionary relationship reasonably accounts for the formation mechanisms of brachiopod paleobiogeography in this region,and also provides a basis for studies on the location and configuration of oceans and plates(blocks)during the late Paleozoic in Central Asia. | WANG ChengWen ZHAO GuoWei LI Ning ZONG Pu | 2013 | Science China Earth Sciences2013，56，12： | 5 |
| 13 | Stratigraphic framework of late Paleozoic in northeastern China显示文摘Late Paleozoic strata in northeastern China are distributed in a zonal pattern around the old-land on the Jiamusi-Mongolia Block.They are composed of active deposits in the regular distributed tectonic lithofacies zones.This indicates that the late Paleozoic strata belong to continental margin deposits.According to the strong conformability of the sedimentary strata in the same continental margin and distinct differences among the three continental margins,three stratigraphical regions of the Jiamusi-Mongolia Stratigraphical Province are recognized along the northern,southern and eastern margins of the Jiamusi-Mongolia Block,named respectively as Xing'an Stratigraphical Region,Inner Mongolia grass--Songhua River Stratigraphical Region and Baoqing--Hunchun Stratigraphical Region.Due to the characteristics of continental margin deposits and active sediments,the strata can be correlated on the level of formation by the methods of analysing the rock association in the same stratigraphic region.Therefore,some revisions of the lithological formations of the late Paleozoic strata in northeastern China have been made,and a new chart of lithostratigraphic correlation has been proposed.Furthermore,the present stratigraphic framework is setting on the International Stratigraphic Chart on the level of stage,after comprehensive researches to lithostratigraphy,biostratigraphy and chronostratigraphy,especially the conodont biostratigraphy and isotopic ages of volcanic rocks obtained in recent years. | WANG Chengwen LI Ning SUN Yuewu ZONG Pu ZHAO Guowei LIU Hui MA Xiaoqin | 2013 | Global Geology2013，16，1： | 4 |
| 14 | Canopy morphological changes and water use efficiency in winter wheat under different irrigation treatments显示文摘Water is a key limiting factor in agriculture. Water resource shortages have become a serious threat to global food security. The development of water-saving irrigation techniques based on crop requirements is an important strategy to resolve water scarcity in arid and semi-arid regions. In this study, field experiments with winter wheat were performed at Wuqiao Experiment Station, China Agricultural University in two growing seasons in 2013-2015 to help develop such techniques. Three irrigation treatments were tested: no-irrigation(i.e., no water applied after sowing), limited-irrigation(i.e., 60 mm of water applied at jointing), and sufficient-irrigation(i.e., a total of 180 mm of water applied with 60 mm at turning green, jointing and anthesis stages, respectively). Leaf area index(LAI), light transmittance(LT), leaf angle(LA), transpiration rate(Tr), specific leaf weight, water use efficiency(WUE), and grain yield of winter wheat were measured. The highest WUE of wheat in the irrigated treatments was found under limited-irrigation and grain yield was only reduced by a small amount in this treatment compared to the sufficient irrigation treatment. The LAI and LA of wheat plants was lower under limited irrigation than sufficient irrigation, but canopy LT was greater. Moreover, the specific leaf weight of winter wheat was significantly lower under sufficient than limited irrigation conditions, while the leaf Tr was significantly higher. Correlation analysis showed that the increased LAI was associated with an increase in the leaf Tr, but the specific leaf weight had the opposite relationship with transpiration. Optimum WUE occurred over a reasonable range in leaf Tr. In conclusion, reduced irrigation can optimize wheat canopies and regulate water consumption, with only small reductions in final yield, ultimately leading to higher wheat WUE and water saving in arid and semi-arid regions. | ZHAO Hong-xiang ZHANG Ping WANG Yuan-yuan NING Tang-yuan XU Cai-long WANG Pu | 2020 | Journal of Integrative Agriculture2020，19，4： | 4 |
| 15 | A Retrospective Cohort Mortality Study in Jinchang,the Largest Nickel Production Enterprise in China显示文摘Nickel is an essential trace metal used in the occupational setting,resulting in both occupational and nonoccupational exposures to individuals at varying levels.Exposure to nickel has been associated with several toxicities and the International Agency for Research on Cancer has concluded that there is sufficient evidence in humans associating exposure to nickel | MA Li BAI Ya Na PU Hong Quan HE Jie Bryan A.Bassig DAI Min ZHANG Ya Wei ZHENG Tong Zhang CHENG Ning | 2014 | Biomedical and Environmental Sciences2014，27，7： | 4 |
| 16 | A review on novel activation strategy on carbonaceous materials with special morphology/texture for electrochemical storage显示文摘Various novel carbonaceous materials including carbon nanotubes,nano-onions,carbon microspheres,graphene nanosheets,and carbon microfibers with unique properties,such as tunable surface area and pore size,high chemical stability,cost-effective and facile preparation,have attracted enormous interest for many applications.Also essential,the activation processes play a critical role to achieve these valuable properties.In this review,we provide a thorough analysis of the emerging nano-and microscopic carbon species with special morphology/textures and currently available types of chemical activation agents,and novel activation strategy to enhance electrochemical performance of activated carbon material in electrical energy storage devices including supercapacitor and alkaline ions batteries.A particular emphasis is set on recent advance in activated carbon materials with special morphology/textures for supercapacitors and sodium ion batteries. | Yueming Li Ziyan Pu Qimeng Sun Ning Pan | 2021 | Journal of Energy Chemistry2021，30，9： | 3 |
| 17 | Calcium intake,calcium homeostasis and health显示文摘Calcium,as the most abundant mineral in human body,is involved in many physiological and pathological processes.Here,we reviewed the key mechanisms of calcium homeostasis,including calcium sensing receptor regulation,intestinal calcium absorption,renal calcium reabsorption and bone calcium resorption.We further discussed the roles of dietary calcium and vitamin D in diseases associated with dysfunctional regulation of calcium.However,the over-dosed consumption of calcium could increase the risks for a series of diseases,such as kidney stone,myocardial infarction and stroke. | Fan Pu Ning Chen Shenghui Xue | 2016 | Food Science and Human Wellness2016，5，1： | 3 |
| 18 | Process design and economic optimization for the indirect synthesis of dimethyl carbonate from urea and methanol显示文摘Much attention has been paid for the synthesis of dimethyl carbonate(DMC) by urea indirect alcoholysis method, which had not been actually industrialized by now. The rigorous full process model was then necessary to optimize the process with heat integration. In this paper, a full process was designed and optimized for the DMC synthesis by urea indirect alcoholysis method based on Aspen Plus software.The technological analysis was developed to find how the process was influenced by the three main recycled materials of methanol, 1,2-propylene glycol(PG) and mixture of DMC–methanol. Simultaneously,the thermal optimization was taken into account for energy saving and the optimized process was proposed with heat integration. Moreover, the economic evaluation was implemented for the optimized process with total annualized cost(TAC) and cost of product(COP) according to the plant investment and operations. It was found that the 11.6% decrease in TAC was obtained for the optimized process compared to the original designed process. The COP analysis showed that the process was economically efficient for the production of DMC from urea and methanol. | Feng Wang Yanfeng Pu Jinhai Yang Taiying Wang Languang Chen Ning Zhao Fukui Xiao | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 3 |
| 19 | Heavy Metal Assessment among Chinese Nonferrous Metal-exposed Workers from the Jinchang Cohort Study显示文摘Environmental exposure to heavy metals has been linked to a wide range of human health hazards.We detected the levels of 15 metals in urine samples from 500 representative sub-samples in an ongoing occupational cohort study(Jinchang Cohort)to directly evaluate metal exposure levels.Fifteen metals,namely As,Ba,Be,Cd,Cs,Cr,Co,Cu,Pb,Mn,Ni,Se,Tl,U,and Zn,were detected by inductively coupled plasma quadruple mass spectrometry.The results showed that median creatinine adjustment and geometric mean urinary metal levels were higher in the heavy metal-exposed group,except Se and Zn,than other reported general or occupational populations.Further studies should address the effects of heavy metals on human health. | YANG Ai Min CHENG Zhi Yuan PU Hong Quan CHENG Ning LI Hai Yan LIU Si Min DING Jiao LI Juan Sheng HU Xiao Bin REN Xiao Wei ZHENG Tong Zhang BAI Ya Na | 2017 | Biomedical and Environmental Sciences2017，30，7： | 2 |
| 20 | Coevolution of Brachiopod Paleobiogeography and Tectonopaleogeography during the Early–Middle Permian显示文摘A comprehensive compilation and systematic analysis of known early and middle Permian brachiopod faunas shows that the early Permian brachiopod faunas comprise three realms, six regions, and eleven provinces, while those of the middle Permian comprise three realms, four regions, and eight provinces. A comparison and analysis of brachiopod faunal patterns reveal a coevolution between global brachiopod paleobiogeography and tectonopaleogeography during the early–middle Permian. Although temperature/latitude is the main factor controlling the formation of three realms, tectonopaleogeographic factors determine the temperature/latitude in which the continents were located. The ‘continental barrier' of Pangea, as a ‘central axis' continent, divided the three realms into six regions, which indicates that the formation of biogeographic regions was controlled mainly by the tectonopaleogeographic factors. The evolution of tectonopaleogeography was sometimes a long-term process, so that the biogeographic regions(or provinces) controlled by tectonopaleogeography displayed relative stability. Shifts in the nature of biogeographic provinces(e.g., from cool water to warm water, and vice versa), extensions or narrowing of geographical ranges, and recombinations of some provinces were all related to regional tectonic evolution. The study of the coevolution between brachiopod paleobiogeography and tectonopaleogeography not only accounts for the formation mechanisms of brachiopod paleobiogeographic patterns during the early–middle Permian, but also provides evidences for the locations and configurations of oceans and plates(blocks) during this period. | WANG Chengwen MAO Yongqin LI Ning ZONG Pu | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 2 |
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