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| 1 | Circular smooth muscle contributes to esophageal shortening during peristalsis显示文摘AIM:To study the angle between the circular smooth muscle(CSM) and longitudinal smooth muscle(LSM) fibers in the distal esophagus.METHODS:In order to identify possible mechanisms for greater shortening in the distal compared to proximal esophagus during peristalsis,the angles between the LSM and CSM layers were measured in 9 cadavers.The outer longitudinal layer of the muscularis propria was exposed after stripping the outer serosa.The inner circular layer of the muscularis propria was then revealed after dissection of the esophageal mucosa and the underlying muscularis mucosa.Photographs of each specimen were taken with half of the open esophagus folded back showing both the outer longitudinal and inner circular muscle layers.Angles were measured every one cm for 10 cm proximal to the squamocolumnar junction(SCJ) by two independent investigators.Two human esophagi were obtained from organ transplant donors and the angles between the circular and longitudinal smooth muscle layers were measured using micro-computed tomography(micro CT) and Image J software.RESULTS:All data are presented as mean ± SE.The CSM to LSM angle at the SCJ and 1 cm proximal to SCJ on the autopsy specimens was 69.3 ± 4.62 degrees vs 74.9 ± 3.09 degrees,P = 0.32.The CSM to LSM angle at SCJ were statistically significantly lower than at 2,3,4 and 5 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 82.58 ± 1.34 degrees,84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.013,P = 0.008,P = 0.004,P = 0.009 respectively.The CSM to LSM angle at SCJ was also statistically significantly lower than the angles at 6,7 and 8 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 80.18 ± 2.09 degrees,81.81 ± 1.75 degrees and 80.96 ± 2.04 degrees,P = 0.05,P = 0.02,P = 0.03 respectively.The CSM to LSM angle at 1 cm proximal to SCJ was statistically significantly lower than at 3,4 and 5 cm proximal to the SCJ,74.94 ± 3.09 degrees vs 84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.019,P = 0.008,P = 0.02 respectively.At 10 cm above SCJ the angle was 80.06 ± 2.13 degrees which is close to being perpendicular but less than 90 degrees.The CSM to LSM angles measured on virtual dissection of the esophagus and the stomach on micro CT at the SCJ and 1 cm proximal to the SCJ were 48.39 ± 0.72 degrees and 50.81 ± 1.59 degrees.Rather than the angle of the CSM and LSM being perpendicular in the esophagus we found an acute angulation between these two muscle groups throughout the lower 10 cm of the esophagus.CONCLUSION:The oblique angulation of the CSM may contribute to the significantly greater shortening of distal esophagus when compared to the mid and proximal esophagus during peristalsis. | Anil K Vegesna Keng-Yu Chuang Ramashesai Besetty Steven J Phillips Alan S Braverman Mary F Barbe Michael R Ruggieri Larry S Miller | 2012 | World Journal of Gastroenterology2012,18,32: | 7 |
| 2 | Insulinoma: pathophysiology, localization and management显示文摘 | Joyce J Shin Phillip Gorden Steven K Libutti | 2010 | Future Oncol2010,,2: | 2 |
| 3 | The Brown Assessment of Be- liefs Scale: Reliability and validity显示文摘 | Eisen J L Phillips K A Baer L | 1998 | Am J Psychiatry1998,155,1: | 1 |
| 4 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010,398,1: | 1 |
| 5 | Ischaemic stroke among young people aged 15 to 50 years in Adelaide, South Australia显示文摘 | PHILLIPS M C LEYDEN J M CHONG W K | 2011 | Med J Aust2011,195,10: | 1 |
| 6 | In vitro absorption of amino acids by the smallintestine of sheep显示文摘 | Phillips W A Webb K E Fontenot J P | 1976 | Journal of Animal Science1976,42,: | 1 |
| 7 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009,458,7238: | 1 |
| 8 | Reproduction in the deepwater squid Moroteuthis ingens 显示文摘 | Jackson G D Semmens J M Phillips K L | 2004 | Mar Biol2004,145,: | 1 |
| 9 | Laminated steel eddy-current loss versus frequency computedusing finite elements显示文摘 | BRAUER J R CENDES Z J BEIHOFF B C PHILLIPS K P | 2000 | IEEE Transactions on IndustryApplications2000,36,4: | 1 |
| 10 | FRVT 2006 and ICE 2006 large-scale ex- perimental results显示文摘 | Phillips P J Scruggs T O'Toole A Flynn P J Bowyer K W Sehott C Sharpe M | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010,32,5: | 1 |
| 11 | Volatile organic com- pounds in breath as markers of lung cancer: A cross-sectional study 显示文摘 | Phillips M Gleeson K Hughes J M B et ctl | 1999 | The Lancet1999,353,9168: | 1 |
| 12 | Positive bowel contrast agent for MR imaging of the abdomen:phase Ⅱ and Ⅲ clinical trials显示文摘 | Patten R M Lo S K Phillips J J | 1993 | Radiology1993,189,1: | 1 |
| 13 | Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred显示文摘 | Thomas AQ Lane K Phillips J | | 0,,9: | 1 |
| 14 | Enhancing the specificity of T-cell cultures for adoptive immunotherapy of cancer显示文摘 | Connie PM Duong Jennifer A Westwood Linda J Berry Phillip K Darcy Michael H Kershaw | 2011 | Immunotherapy2011,,1: | 1 |
| 15 | Locked nucleic acid based beacons for surface interaction studies and biosensor development显示文摘 | MARTLNEZ K ESTEVEZ M C WU Y R PHILLIPS J A MEDLLEY C D TAN W H | 2009 | Anal Chem2009,81,9: | 1 |
| 16 | Exercise,antioxidants,and HSP72:protection against myocardial ischemia/reperfusion显示文摘 | Hamilton K L Staib J L Phillips T | 2003 | Free Radic Biol Med2003,34,7: | 1 |
| 17 | Volatile organic com-pounds in breath as markers of lung cancer:A cross-sectionalstudy显示文摘 | Phillips M Gleeson K Hughes J M | 1999 | Lancet1999,353,: | 1 |
| 18 | A microsphere based vaccine prevents and reverses new-onset autoimmune diabetes 显示文摘 | PHILLIPS B NYLANDER K HARNAHA J | 2008 | Diabetes2008,57,6: | 1 |
| 19 | Pediatric liver transplantation显示文摘 | Susan K Phillips J | 2002 | Progress in Trasplantation2002,12,: | 1 |
| 20 | Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study显示文摘 | PHILLIPS M GLEESON K HUGHES J M | 1999 | Lancet1999,,353: | 1 |