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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 3 | Fouling in membrane bioreactors used in wastewater treatment 显示文摘 | PIERRE L C VICKI C TONY A G | 2006 | Journal of Membrane Science2006，284，： | 1 |
| 4 | Ridge-line optimal detector显示文摘 | Pierre G Hayet L Remi K | | 0，，： | 1 |
| 5 | Magnetite nanoparticle dispersions stabilized with triblock copolymers显示文摘 | Harris L A Goff J D Carmichael A Y Riffle J S Harburn J J Pierre T G S Saunders M | 2003 | Chemistry of Materials2003，15，： | 1 |
| 6 | A chemical model for the dispersion of fillers in a polymeric matrix显示文摘 | TOMAS L PIERRE G E MIROSLAV G | 2002 | Can J Chem Eng2002，80，6： | 1 |
| 7 | Real investment decision under adjustment costs and asymmetric information显示文摘 | Gauder G Pierre L Long I V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 8 | Volume velocity control of sound transmission through composite panels显示文摘 | Pierre P L Koopmann G H Chen W | 1998 | Journal of Sound and Vibration1998，210，4： | 1 |
| 9 | Real investment decisions under adjustment costs and asymmetric information显示文摘 | Gauder G Pierre L Long I V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 10 | Fouling in membrane bioreactors used in wastewater treatment显示文摘 | Pierre L C C Tony A G F | 2006 | Membrane Science2006，284，34： | 1 |
| 11 | Rho kinases in cardiovascular physio-logy and pathophysiology显示文摘 | Gervaise L Patrice G Pierre P | 2006 | Circ Res2006，98，3： | 1 |
| 12 | Magnesium alloys(WE43 and ZE41 ) characterization for laser applications 显示文摘 | Sorin l Pierre S Dominique G | 2004 | Applied SurfaceSeienee2004，233，14： | 1 |
| 13 | Isotope Study on Diffusionin CaS04 Formed During Sorbent-Flue-Gas Reaction显示文摘 | Hsia C St Pierre G R Fan L S | 1995 | AIChE Journal1995，41，10： | 1 |
| 14 | Knowledge and practices on hypertension in acountry in epidem io Log: caltranstion 显示文摘 | Audert L Pasal B Jean - pierre G | 1998 | Hypertension1998，31，5： | 1 |
| 15 | Fouling in membrane bioreactors used inwastewaterreatment显示文摘 | PIERRE L C CHEN V FANE T A G | 2006 | J MembrSci2006，284，： | 1 |
| 16 | Pro-gastrin-releasing peptide, neuron specific enolase and chromogranin A as serum markers of small cell lung cancer 显示文摘 | Pierre L Jean G Andrew K et 81 | 2000 | Lung Cancer2000，29，： | 1 |
| 17 | The Integrated System for Public Health Monitoring of West Nile Vims(ISPHM-WNV):a real-time GIS for surveillance and decision-making显示文摘 | Pierre G Germain L Sonia R | 2005 | Intemational Journal of Health Geographics2005，4，1： | 1 |
| 18 | A 1166C polymorphism of angiotensin Ⅱ type Ⅰ receptor: blood pressure and arterial stiffness in hypertension显示文摘 | Ste' phany G Madeleine V Pierre L | 2004 | Journal of Hypertension2004，22，11： | 1 |
| 19 | Isotope study on diffusion in CaSO4 formed during sorhent-flue-gas reaction 显示文摘 | Hsia C Pierre G R Fan L S | 1995 | AIChE Journal1995，41，10： | 1 |
| 20 | Some Recent Advancesin the Design and the Use of Miniaturized Droplet-BasedContinuous Process:Applications in Chemistry and High-Pressure Microflows显示文摘 | Nicolas L Flavie S Pierre G | 2011 | Lab on a Chip2011，11，： | 1 |
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