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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3h0xp0qfqf5onf6up6.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 3 | Phytop]ankton population dynamics at the Bermuda Atlantic Time-Series station in the Sargasso Sea显示文摘 | DuRand M D Olson R J Chisholm S W | 2001 | Deep-Sea Res Pt II2001，48，： | 1 |
| 4 | Role of Derlin-I protein in proteostasis regulation of ATP-sensitive potas- sium channels显示文摘 | WANG F OLSON E M SHYNG S L | 2012 | J Biol Chem2012，287，10： | 1 |
| 5 | Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid显示文摘 | Widenfalk J Lundstromer K Jubran M Brene S Olson L | 2001 | J Neurosci2001，21，10： | 1 |
| 6 | Microvascular decompression for trigeminal neuralgia:recurrences and complications显示文摘 | Olson S Atkinson L Weidmann M | 2005 | J Clin Neurosci2005，12，7： | 1 |
| 7 | Microvascular decompression for trigeminal neuralgia: recurrences and complications显示文摘 | Olson S Atkinson L Weidmann M | 2005 | J Clin Neurosci2005，12，7： | 1 |
| 8 | The contingent value of responsive and proactive market orientations for new product program performance显示文摘 | ATUAHENE-GIMA K SLATER S F OLSON E M | 2005 | Journal of Product Innovation Management2005，22，6： | 1 |
| 9 | Ribosomal inhibito- ry proteins from plants inhibits HIV-1 replication in acutely infected peripheral blood mononuclear cells显示文摘 | Olson M Ramakrishana S Anand R | 1991 | AIDS Res Hum Retroviruses1991，7，12： | 1 |
| 10 | Distance Matters显示文摘 | Olson G M Olson J S | 2002 | Human Computer Interaction2002，，15： | 1 |
| 11 | Endovascular treatment of celiac and mesenteric arteries stenoses:applicationsand results显示文摘 | SHARAFUDDIN M J OLSON C H SUN S | 2003 | J Vasc Surg2003，38，4： | 1 |
| 12 | Co - innovation : Convergenom- ies, collaboration, and co - creation for organizational values 显示文摘 | SANG M L OLSON D L TRIMI S | 2012 | Management Decision2012，50，5： | 1 |
| 13 | 显示文摘 | Olson D C Lee Y J White M S | 2008 | Phys Chem C2008，112，26： | 1 |
| 14 | Strategy type and perform- ance; the influence of sales force management显示文摘 | SLATER S F OLSON E M | 2000 | Strategic Management Journal2000，21，8： | 1 |
| 15 | Flue gas effects on a carbon-based mercury sorbent显示文摘 | Stanley J M Grant E D Olson E S | | 0，，03： | 1 |
| 16 | Status review of mercurycontrol options for coal-fired power plants显示文摘 | PAVLISH J H SONDREAL E A MANN M D OLSON E S GALBREATH K C LAUDAL D L BENSON S A | 2003 | Fuel Process Technol2003，82，23： | 1 |
| 17 | In vitro metabolism of ceftiofur in bovine tissues显示文摘 | Olson S C Beconi-Barker M G Smith E B | 1998 | 21(2):112-1201998，21，2： | 1 |
| 18 | 查看详情显示文摘 | Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th | | 0，，： | 1 |
| 19 | The contingent value of responsive and proactive market orientations for new product program performance显示文摘 | ATUAHENE-GIMA K SLATER S F OLSON E M | 2005 | Journal of Product Innovation Management2005，22，6： | 1 |
| 20 | Lactobacilli ac- tivate human dendritic cells that skew T cells toward T helper 1 polarization显示文摘 | Mohamadzadeh M Olson S Kalina W V | 2005 | P Nati Acad Sci USA2005，102，8： | 1 |
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