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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Improved recoverability of microbial colonies from marine sponge samples显示文摘 | Olson J B Lord C C McCarthy P J | 2000 | Microbial Ecology2000，40，： | 1 |
| 3 | Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis? 显示文摘 | ERNST C OLSON A K PINEL J P | 2006 | J Psy Neuro2006，31，2： | 1 |
| 4 | Beliefs in a Just World,Discontent,and Assertive Actions by Working Women显示文摘 | Hafer C L Olson J M | | 0，，01： | 1 |
| 5 | Immunoglobulin heavy H chain isotypes in a teleost fish 显示文摘 | LOBB C J OLSON M O | 1988 | Immunology1988，141，4： | 1 |
| 6 | Sensation of warmth as affected by the color of the environment显示文摘 | Hougenten F C Olson H T Suciu J | 1940 | J Illuminating Engineering1940，30，10： | 1 |
| 7 | Intraepithelial CDS+ tumor-infiltrating lymphocytes and a high CD8+/regnlatory T cell ratio are associated with favorable prognosis in ovarian cancer显示文摘 | Sato E Olson SH Ahn J Bundy B Nishikawa H Qian F Jungbluth AA Frosina D Gnjatic S Ambrosone C Kepner J Odunsi T Ritter G Lele S Chen YT Ohtani H Old LJ Odunsi K | 2005 | Proc Natl Acad Sci USA2005，102，18： | 1 |
| 8 | Endovascular treatment of celiac and mesenteric arteries stenoses:applicationsand results显示文摘 | SHARAFUDDIN M J OLSON C H SUN S | 2003 | J Vasc Surg2003，38，4： | 1 |
| 9 | Penetrating keratoplasty for keratoconns: a long-term review of results and complications 显示文摘 | Olson R J Pingree M Ridges R Lundergan ML Alldredge C Clinch TE | 2000 | J Cataract Refract Surg2000，26，7： | 1 |
| 10 | 显示文摘 | Olson D C Lee Y J White M S | 2008 | Phys Chem C2008，112，26： | 1 |
| 11 | Hybrid pho- tovoltaic devices of polymer and ZnO nanofiber com- posites显示文摘 | Olson D C Piris J Collins R T etal | 2006 | Thin Solid Films2006，496，1： | 1 |
| 12 | Status review of mercurycontrol options for coal-fired power plants显示文摘 | PAVLISH J H SONDREAL E A MANN M D OLSON E S GALBREATH K C LAUDAL D L BENSON S A | 2003 | Fuel Process Technol2003，82，23： | 1 |
| 13 | The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation显示文摘 | Momand J Zambetti G P Olson D C | | 0，，： | 1 |
| 14 | Upregulation of fibroblast growth factors and their receptors during multistage epidermal carcinogenesis in K14-HPV16 transgenic mice 显示文摘 | Arbeit J M Olson D C Hanaham D | 1996 | Oncogene1996，13，9： | 1 |
| 15 | An image-processing strategy for the segmentation and quantification in fluorescein angiograms of the ocular fundus显示文摘 | SPENCER T OLSON J A MCHARDY K C | | 0，，： | 1 |
| 16 | Reg-ulation of adipose branched-chain amino acid catabo-lism enzyme expression and cross-adipose amino acidflux in human obesity 显示文摘 | LACKEY D E LYNCH C J OLSON K C | 2013 | American Journal of Physi-ology :Endocrinology and Metabolism2013，304，11： | 1 |
| 17 | Mucoepidermoid carcinoma of the bronchus: an electron microscopic study of the low grade and the high grade variants 显示文摘 | Klacsmann P G Olson J L Eggleston J C | 1979 | Cancer1979，43，5： | 1 |
| 18 | Ammonium chloride and ammonium sulfate for prevention of parturient paresis in dairy cows显示文摘 | OETZEL G R OLSON J D CURTIS C R | 1988 | Dairy Sci1988，71，： | 1 |
| 19 | RAS and RHO GTPases in G1-phase cell-cycle regulation 显示文摘 | Coleman ML Marshall C J Olson MF | 2004 | Nat Rev Mol Cell Biol2004，5，5： | 1 |
| 20 | Disease emer- gence from global climate and landuse change 显示文摘 | PATZ J A OLSON S H UEJIO C K | 2008 | Med Clin North Am2008，92，6： | 1 |
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