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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Prognostic value of epidermal growth factor receptors in gastric cancer: a survival analysis by Weibull model incorporating long-term survivors显示文摘 | Alexandre Andrade Anjos Jácome Durval R. Wohnrath Cristovam Scapulatempo Neto Estela C. Carneseca Sérgio V. Serrano Luciano Souza Viana Jo?o S. Nunes Edson Z. Martinez José Sebasti?o Santos | 2014 | Gastric Cancer2014，，1： | 2 |
| 4 | Improved control of postharvest decay of pears by the combination of Candida sake (CPA 1) and ammonium molybdate 显示文摘 | Nunes C Usall J Teixido N | 2002 | Phytopathology2002，92，： | 1 |
| 5 | The outcome of oral mucosal grafts to the orbit : a three - and - a - half - year study显示文摘 | Bowen E J Nunes E | 2002 | Br J Plast surg2002，55，2： | 1 |
| 6 | Image analysis by bidimensional empirical mode decomposition显示文摘 | Nunes J C Bouaoune Y Delechelle E | 2003 | Image and Vision Computing2003，21，12： | 1 |
| 7 | Dielectric study of milk for frequencies between 1 and 20GHz 显示文摘 | Nunes A C Bohigas X Tejada J | 2006 | Journal of Food Engineering2006，76，： | 1 |
| 8 | Effect of frozen storage on thechemical and physical properties of black and silver scabbard fish显示文摘 | DAIAS J NUNES M L MENDES R | 1994 | Journal of the Science of Food and Agriculture1994，66，3： | 1 |
| 9 | Image analysis bybidimensional empirical mode decomposition显示文摘 | Nunes J C Bouaoune Y Delechelle E | 2003 | Image andVision Computing2003，21，12： | 1 |
| 10 | Impact of OSA on cardiovascular events after coronary artery bypass surgery显示文摘 | UCHOA C H DANZI-SOARES NDE J NUNES F S | 2015 | Chest2015，147，： | 1 |
| 11 | Influence of the variable-speed wind generators in transient stability margin of the conven tional generators integrated in electrical grids显示文摘 | Nunes Marcus V A Lopes J A Pecas Zurn Hans Helmut | 2004 | IEEE Trans on Energy Conversion2004，19，4： | 1 |
| 12 | Signaling status with luxury goods: The role of brand prominence显示文摘 | Han Y J Nunes J C Dreze X | 2010 | Journal of Marketing2010，74，4： | 1 |
| 13 | Eimeria in- fections in goats in Southern Portugal 显示文摘 | SILVA L M R VILA - VICOSA M J M NUNES T | 2014 | Rev Bras Parasitol Vet2014，23，2： | 1 |
| 14 | Exploiting dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS) for sequential determination of trace elements in blood using a dilute-and-shoot procedure 显示文摘 | Batista B L Rodrigues J L Nunes J A | 2009 | Analytiea Chimica Acta2009，639，： | 1 |
| 15 | Magnetic microstructure of YFell Ti aggregates 显示文摘 | Nunes D Colaco R de Hosson JTM Gonclves A P Pereira L C J Carvalho P A | 2009 | Journal of Alloys and Compounds2009，487，12： | 1 |
| 16 | Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendroeytes within demyelinated lesions of the rat brain显示文摘 | Windrem M S Roy N S Wang J Nunes M Benraiss A Goodman R | 2002 | J Neurosei Res2002，69，： | 1 |
| 17 | Renal diseases: a 27-year renal biopsy study显示文摘 | Carvalho E do-Sameiro-Faria M Nunes J P | 2006 | J Nephrol2006，19，4： | 1 |
| 18 | Discovery of aminoquinazolines as potent,orally bioavailable inhib-itors of Lck: Synthesis, SAR, and in vivo anti-inflanunato- ry activity显示文摘 | Dimauro E F Newcomb J Nunes J J | 2006 | J Med Chem2006，49，： | 1 |
| 19 | Acute ischaemic stroke during ambulatory blood pressure monitoring显示文摘 | NUNES J P FRIA M D S POLONIA J J | 1992 | Lancet1992，339，2： | 1 |
| 20 | Conspicuous consumption in a recession: Toning it down or turning it up?显示文摘 | Nunes J C Dreze X Han Y J | 2011 | Journal of Consumer Psychology2011，21，2： | 1 |
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