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| 1 | Prognostic value of brain natiuretic peptide in acute heart failure:mortalitàand hospital redmission显示文摘 | Núez J Núez E Robies R | 2008 | Rev Esp Cardiol2008，61，12： | 1 |
| 2 | Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction显示文摘 | Nú(n)ez J Nú(n)ez E Bodi V | | 0，，06： | 1 |
| 3 | A single amino acid sub-stitution in nonstructural protein 3 A can mediate adaptation of foot-and-mouth disease virus to the Guinea pig显示文摘 | Nú?ez J I Baranowski E Molina N | | 0，，08： | 1 |
| 4 | LC-MS/MS analysis of organic toxics in food显示文摘 | Nú?ez O Moyano E Galceran MT | | 0，，07： | 1 |
| 5 | Prognostic value of baseline white blood cell count in patients with acute myocardial infarction and ST segment elevation显示文摘 | Núez JE Núez E Bertomeu V | 2005 | Heart2005，91，8： | 1 |
| 6 | Genetic Characterization of a Single Bifunctional Enzyme for Fumarate Reduction and Succinate Oxidation in Geobacter sulfurreducens and Engineering of Fumarate Reduction in Geobacter metallireducens显示文摘 | Butler J E Glaven R H Esteve-Nú(n)ez A | 2006 | Journal of Bacteriology2006，188，2： | 1 |
| 7 | Determination of nonylphenol and nonylphenol ethoxylates in environmental solid samples by ultrasonicassisted extraction and high performance liquid chromatographyfluorescence detection显示文摘 | Núez L Turiel E Tadeo J L | 2007 | Journal of Chromatography:A2007，1146，2： | 1 |
| 8 | A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis显示文摘 | Nú?ez L E Nybo S E González-Sabín J | 2012 | J Med Chem2012，55，12： | 1 |
| 9 | Association between the A1166C polymorphism of the angiotensin Ⅱ receptor type 1 and progression of chronic renal insufficiency显示文摘 | Coll E Campos B González-Nú(n)ez D | | 0，，03： | 1 |
| 10 | Using components of the vitamin D pathway to prevent and treat colon cancer显示文摘 | Renee E Stubbins Aisha Hakeem Nomelí P Nú?ez | 2012 | Nutrition Reviews2012，，12： | 1 |
| 11 | Identification of Vibrio harveyi isolated from diseased cultured wedge sole Dicologoglossa cuneata显示文摘 | López J R de la Roca E Núez S | 2009 | Dis Aquat Org2009，84，： | 1 |
| 12 | El nogal pecanero en Sonora显示文摘 | Nú?EZ M VALDEZ B MARTíNEZ G VALENZUELA E | 2001 | Libro Técnico2001，3，： | 1 |
| 13 | Analysis of the herbicides paraquat,diquat and difenzoquat in drinking water by micellar electrokinetic chromatography using sweeping and cation selective exhaustive injection显示文摘 | Nú(n)ez O Kim J B Moyano E etal | 2002 | Chromatogr A2002，，1： | 1 |
| 14 | In vitro assessment of antifungical agents used in the tanning industry显示文摘 | Nú nez M G Vera D V Reinoso H E | 1998 | JSLTC1998，，82： | 1 |
| 15 | Evaluation of four rapid methods for hemoglobin screening of whole blood donors in mobile collection settings显示文摘 | Gómez-Simón A Navarro-Núez L Pérez-Ceballos E | 2007 | Transfus Apher Sci2007，36，3： | 1 |
| 16 | Differential prognostic effect of systolic blood pressure on mortality according to left-ventricular function in patients with acute heart failure显示文摘 | Núez J Núez E Fonarow GC | 2010 | Eur J Heart Fail2010，12，1： | 1 |
| 17 | Leaf nutrient levels for pecans显示文摘 | POND A P WALWORTH J L KILBY M W GIBSON R D CALL R E Nú?EZ H | 2006 | Hort Science2006，41，5： | 1 |
| 18 | Statistical model to analyze quantitative proteomics data obtained by 18O/16O labeling and linear ion trap mass spectrometry:application to the study of vascular endothelial growth factor-induced angiogenesis in endothelial cells显示文摘 | Jorge I Navarro P Martínez-Acedo P Nú(n)ez E Serrano H Alfranca A Redondo J M Vázquez J | | 0，，05： | 1 |
| 19 | A functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population显示文摘瞄准:在乳糜泻(CD ) 探讨 CD209 的角色病人。非人类的白血球抗原(HLA ) 在 CD 倾向的基因因素糟糕被理解,并且象传染病原体一样的环境因素可以起一个作用。CD209 是一树枝状并且涉及病原体识别和有免疫力的激活的巨噬细胞表面分子。最近,在 CD209 基因的倡导者的功能的变体(-336A/G) 被显示了影响 transcriptional CD209 活动在试管内,它与感染的更高的危险性 to/or 严厉被联系了。方法:学习人口由 103 和 386 个 CD 病人和 312 y 的二个盒子控制队组成象 257 个腹的家庭的一块面板一样的 419 健康控制。为 -336A/G CD209 倡导者多型性的 Genotyping 用 TaqMan 5' 被执行突变而产生之遗传的辨别试金。HLA-DQ 被杂交与等位基因 specific 探针决定。结果:开始,盒子控制和家庭研究没与 CD 危险性发现 -336 A/G CD209 基因变体的任何协会。然而,由 HLA-DQ2 的层化确实在 HLA-DQ2 (-) 组揭示了 CD209 倡导者多型性的一个重要协会(在 DQ2 (-) 对 DQ2 (+) 病人的搬运人 A 对 GG (P = 0.026,或 = 3.71 ) 。结论:-336G CD209 等位基因似乎在 HLA-DQ2 (-) 病人涉及 CD 危险性。我们的结果可能在 CD 病人的一个次要的组的发作建议病原体的一个可能的角色。 | C Nú■ez B Rueda A Martínez C Maluenda I Polanco MA López-Nevot E Ortega E Sierra E Gómez de la Concha E Urcelay J Martín | 2006 | World Journal of Gastroenterology2006，12，27： | 1 |
| 20 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
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