|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Maintenance Peginterferon Therapy and Other Factors Associated With Hepatocellular Carcinoma in Patients With Advanced Hepatitis C显示文摘 | Anna S. Lok James E. Everhart Elizabeth C. Wright Adrian M. Di Bisceglie Hae–Young Kim Richard K. Sterling Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Timothy R. Morgan | 2011 | Gastroenterology2011，，3： | 4 |
| 2 | Genomic prediction of fruit texture and training population optimization towards the application of genomic selection in apple显示文摘Texture is a complex trait and a major component of fruit quality in apple.While the major effect of MdPG1,a gene controlling firmness,has already been exploited in elite cultivars,the genetic basis of crispness remains poorly understood.To further improve fruit texture,harnessing loci with minor effects via genomic selection is therefore necessary.In this study,we measured acoustic and mechanical features in 537 genotypes to dissect the firmness and crispness components of fruit texture.Predictions of across-year phenotypic values for these components were calculated using a model calibrated with 8,294 SNP markers.The best prediction accuracies following cross-validations within the training set of 259 genotypes were obtained for the acoustic linear distance(0.64).Predictions for biparental families using the entire training set varied from low to high accuracy,depending on the family considered.While adding siblings or half-siblings into the training set did not clearly improve predictions,we performed an optimization of the training set size and composition for each validation set.This allowed us to increase prediction accuracies by 0.17 on average,with a maximal accuracy of 0.81 when predicting firmness in the‘Gala’בPink Lady’family.Our results therefore identified key genetic parameters to consider when deploying genomic selection for texture in apple.In particular,we advise to rely on a large training population,with high phenotypic variability from which a‘tailored training population’can be extracted using a priori information on genetic relatedness,in order to predict a specific target population. | Morgane Roth Hélène Muranty Mario Di Guardo Walter Guerra Andrea Patocchi Fabrizio Costa | 2020 | Horticulture Research2020，7，1： | 4 |
| 3 | Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease显示文摘 | Anna S. Lok Leonard B. Seeff Timothy R. Morgan Adrian M. di Bisceglie Richard K. Sterling Teresa M. Curto Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Zachary D. Goodman | 2009 | Gastroenterology2009，，1： | 3 |
| 4 | Des-γ-Carboxy Prothrombin and α-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma显示文摘 | Anna S. Lok Richard K. Sterling James E. Everhart Elizabeth C. Wright John C. Hoefs Adrian M. Di Bisceglie Timothy R. Morgan Hae–Young Kim William M. Lee Herbert L. Bonkovsky Jules L. Dienstag | 2010 | Gastroenterology2010，，2： | 2 |
| 5 | Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease显示文摘 | Anna S. Lok Leonard B. Seeff Timothy R. Morgan Adrian M. di Bisceglie Richard K. Sterling Teresa M. Curto Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Zachary D. Goodman | 2009 | Gastroenterology2009，，1： | 1 |
| 6 | Determination of vol- atile organic compounds and respirable suspended particulate mat- ter in New Jersey and Pennsylvania homes and workplaces 显示文摘 | Heavner DI Morgan WT Ogden MW | 1996 | En- vironment International1996，22，2： | 1 |
| 7 | Effectiveness of an early supplementation scheme of high does vitam in A versus standard WHO protocol in Gambian mothers and infants a ran domised controlled trial显示文摘 | Darboe MK Thurnham DI Morgan G | | 0，，9579： | 1 |
| 8 | Serum alpha-fetoprotein levels in patients with advanced hepatitis C: Results from the HALT-C Trial显示文摘 | Adrian M. Di Bisceglie Richard K. Sterling Raymond T. Chung James E. Everhart Jules L. Dienstag Herbert L. Bonkovsky Elizabeth C. Wright Gregory T. Everson Karen L. Lindsay Anna S.F. Lok William M. Lee Timothy R. Morgan Marc G. Ghany David R. Gretch the H | 2005 | Journal of Hepatology2005，，3： | 1 |
| 9 | Serum alpha-fetoprotein levels in patients with advanced hepatitis C: Results from the HALT-C Trial显示文摘 | Adrian M. Di Bisceglie Richard K. Sterling Raymond T. Chung James E. Everhart Jules L. Dienstag Herbert L. Bonkovsky Elizabeth C. Wright Gregory T. Everson Karen L. Lindsay Anna S.F. Lok William M. Lee Timothy R. Morgan Marc G. Ghany David R. Gretch the H | 2005 | Journal of Hepatology2005，，3： | 1 |
| 10 | A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis显示文摘Several developmental stages of spermatogenesis are transcriptionally quiescent which presents major challenges associated with the regulation of gene expression. Here we identify that the zygotene to pachytene transit!on is not only associated with the resumption of transcription but also a wave of programmed mRNA degradation that is essential for meiotic progress!on. We explored whether terminal uridydyl transferase 4-(TUT4-) or TUT7-mediated 3' mRNA uridylation contributes to this wave of mRNA degradation during pachynema. Indeed, both TUT4 and TUT7 are expressed throughout most of spermatogenesis, however, loss of either TUT4 or TUT7 does not have any major impact upon spermatogenesis. Combined TUT4 and TUT7 (TUT4/7) deficiency results in embryonic growth defects, while conditional gene targeting revealed an essential role for TUT4/7 in pachytene progression. Loss of TUT4/7 results in the reduction of miRNA, piRNA and mRNA 31 uridylation. Although this reduction does not greatly alter miRNA or piRNA expression, TUT4/7-mediated uridylation is required for the clearanee of many zygotene-expressed transcripts in pachytene cells. We find that TUT4/7-regulated transcripts in pachytene spermatocytes are characterized by having long 3Z UTRs with length-adjusted enrichment for AU-rich elements. We also observed these features in TUT4/7-regulated maternal transcripts whose dosage was recently shown to be essential for sculpting a functional maternal transcriptome and meiosis. Therefore, mRNA 3Z uridylation is a critical determinant of both male and female germline transcriptomes. In conclusion, we have identified a novel requirement for 3' uridylation-programmed zygotene mRNA clearanee in pachytene spermatocytes that is essential for male meiotic progression. | Marcos Morgan Yuka Kabayama Christian Much Ivayla Ivanova Monica Di Giacomo Tatsiana Auchynnikava Jack Michael Monahan Dimitrios Michael Vitsios Lina Vasiliauskaite Stefano Comazzetto Juri Rappsilber Robin Campbell Allshire Bo Torben Porse Anton James Enright Donal O'Carroll | 2019 | Cell Research2019，29，3： | 1 |
| 11 | Epigenetic inheritance at the agouti locus in the mouse 显示文摘 | Morgan HD Suther/and HG Martin DI | 1999 | Nat Genet1999，23，3： | 1 |
| 12 | Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease显示文摘 | Anna S. Lok Leonard B. Seeff Timothy R. Morgan Adrian M. di Bisceglie Richard K. Sterling Teresa M. Curto Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Zachary D. Goodman | 2009 | Gastroenterology2009，，1： | 1 |
| 13 | Zoo- plankton species composition is linked to ocean trans port in the Northern California Current 显示文摘 | Keister J E Di Lorenzo E Morgan C A | 2011 | Global Change Biology2011，17，7： | 1 |
| 14 | Identification of a single base change in ribosomal RNA leading to eryth-romycin resistance 显示文摘 | Vannuffel P Di Giambattista M Morgan E A | 1992 | J Biol Chem1992，267，12： | 1 |
| 15 | Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease显示文摘 | Anna S. Lok Leonard B. Seeff Timothy R. Morgan Adrian M. di Bisceglie Richard K. Sterling Teresa M. Curto Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Zachary D. Goodman | 2009 | Gastroenterology2009，，1： | 1 |
| 16 | Outcome of sustained virological responders with histologically advanced chronic hepatitis C显示文摘 | Timothy R. Morgan Marc G. Ghany Hae‐Young Kim Kristin K. Snow Mitchell L. Shiffman Jennifer L. De Santo William M. Lee Adrian M. Di Bisceglie Herbert L. Bonkovsky Jules L. Dienstag Chihiro Morishima Karen L. Lindsay Anna S. F. Lok | 2010 | Hepatology2010，，3： | 1 |
| 17 | Maintenance Peginterferon Therapy and Other Factors Associated With Hepatocellular Carcinoma in Patients With Advanced Hepatitis C显示文摘 | Anna S. Lok James E. Everhart Elizabeth C. Wright Adrian M. Di Bisceglie Hae–Young Kim Richard K. Sterling Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Timothy R. Morgan | 2011 | Gastroenterology2011，，3： | 1 |
| 18 | Serum alpha-fetoprotein levels in patients with advanced hepatitis C: Results from the HALT-C Trial显示文摘 | Adrian M. Di Bisceglie Richard K. Sterling Raymond T. Chung James E. Everhart Jules L. Dienstag Herbert L. Bonkovsky Elizabeth C. Wright Gregory T. Everson Karen L. Lindsay Anna S.F. Lok William M. Lee Timothy R. Morgan Marc G. Ghany David R. Gretch the H | 2005 | Journal of Hepatology2005，，3： | 1 |
| 19 | Opportunities to search for extraterrestrial intelligence with the FAST显示文摘The discovery of ubiquitous habitable extrasolar planets,combined with revolutionary advances in instrumentation and observational capabilities,has ushered in a renaissance in the search for extraterrestrial intelligence(SETI).Large scale SETI activities are now underway at numerous international facilities.The Five-hundred-meter Aperture Spherical radio Telescope(FAST)is the largest single-aperture radio telescope in the world,and is well positioned to conduct sensitive searches for radio emission indicative of exo-intelligence.SETI is one of the five key science goals specified in the original FAST project plan.A collaboration with the Breakthrough Listen Initiative was initiated in 2016 with a joint statement signed both by Dr.Jun Yan,the then director of National Astronomical Observatories,Chinese Academy of Sciences(NAOC),and Dr.Peter Worden,Chairman of the Breakthrough Prize Foundation.In this paper,we highlight some of the unique features of FAST that will allow for novel SETI observations.We identify and describe three different signal types indicative of a technological source,namely,narrow band,wide-band artificially dispersed and modulated signals.Here,we propose observations with FAST to achieve sensitivities never before explored.For nearby exoplanets,such as TESS targets,FAST will be sensitive to an EIRP of 1.9×1011 W,well within the reach of current human technology.For the Andromeda Galaxy,FAST will be able to detect any Kardashev type II or more advanced civilization there. | Di Li Vishal Gajjar Pei Wang Andrew Siemion Zhi-Song Zhang Hai-Yan Zhang You-Ling Yue Yan Zhu Cheng-Jin Jin Shi-Yu Li Sabrina Berger Bryan Brzycki Jeff Cobb Steve Croft Daniel Czech David DeBoer Julia DeMarines Jamie Drew J.Emilio Enriquez Nectaria Gizani Eric J.Korpela Howard Isaacson Matthew Lebofsky Brian Lacki David H.E.MacMahon Morgan Nanez Chen-Hui Niu Xin Pei Danny C.Price Dan Werthimer Pete Worden Yunfan Gerry Zhang Tong-Jie Zhang FAST Collaboration | 2020 | Research in Astronomy and Astrophysics2020，20，5： | 1 |
| 20 | Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis显示文摘 | Herbert L. Bonkovsky Kristin K. Snow Peter F. Malet Carla Back-Madruga Robert J. Fontana Richard K. Sterling Clark C. Kulig Adrian M. Di Bisceglie Timothy R. Morgan Jules L. Dienstag Marc G. Ghany David R. Gretch | 2006 | Journal of Hepatology2006，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员