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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Short and long term outcomes of 200 patients supported by continuous-flow left ventricular assist devices显示文摘AIM: To study the institutional experience over 8 years with 200 continuous-flow(CF)- left ventricular assist devices(LVAD).METHODS: We evaluated our institution's LVAD database and analyzed all patients who received a CF LVAD as a bridge to transplant(BTT) or destination therapy from March 2006 until June 2014. We identified 200 patients, of which 179 were implanted with a Heart Mate II device(Thoratec Corp., Pleasanton, CA) and 21 received a Heartware HVAD(Heart Ware Inc., Framingham, MA).RESULTS: The mean age of our LVAD recipients was 59.3 years(range 17-81), 76%(152/200) were males, and 49% were implanted for the indication of BTT. The survival rate for our LVAD patients at 30 d, 6 mo, 12 mo, 2 years, 3 years, and 4 years was 94%, 86%, 78%, 71%, 62% and 45% respectively. The mean duration of LVAD support was 581 d(range 2-2595 d). Gastrointestinal bleeding(was the most common adverse event(43/200, 21%), followed by right ventricular failure(38/200, 19%), stroke(31/200, 15%), re exploration for bleeding(31/200, 15%),ventilator dependent respiratory failure(19/200, 9%) and pneumonia(15/200, 7%). Our driveline infection rate was 7%. Pump thrombosis occurred in 6% of patients. Device exchanged was needed in 6% of patients. On multivariate analysis, preoperative liver dysfunction, ventilator dependent respiratory failure, tracheostomy and right ventricular failure requiring right ventricular assist device support were significant predictors of post LVAD survival.CONCLUSION: Short and long term survival for patients on LVAD support are excellent, although outcomes still remain inferior compared to heart transplantation. The incidence of driveline infections, pump thrombosis and pump exchange have declined significantly in recent years. | Athanasios Tsiouris Gaetano Paone Hassan W Nemeh Jamil Borgi Celeste T Williams David E Lanfear Jeffrey A Morgan | 2015 | World Journal of Cardiology2015，7，11： | 5 |
| 3 | 比色法测定N-乙酰葡糖胺和N-乙酰半乳糖胺显示文摘乙酰葡糖胺与对二甲氨基苯甲醛的反应最初由Müller发现,即当戊-乙酰葡糖胺溶液与稀氢氧化钾共热后,加入盐酸酸化的对二甲氨基苯甲醛溶液(Ehrlich试剂)可产生强紫红色。 | Morgan W T J Elson L A 陈祥娥 | 2010 | 食品与药品2010，12，9： | 2 |
| 4 | A restrospective review of treatment of the odontogenic cyst显示文摘 | MORGAN T A BURTON C C QIAN F | 2005 | Br J Oral Mazillofac Surg2005，63，5： | 1 |
| 5 | Cloud top Altitude Measurements from Satellites 显示文摘 | Saiedy F Hilleary D T Morgan W A | 1965 | Applied Optics1965，4，： | 1 |
| 6 | Clinical efficacy of perindopril in hypertension显示文摘 | Morgan T Anderson A | 1992 | Clin Exp Pharmacd Physiol1992，19，1： | 1 |
| 7 | Retention of oncogenicity by a Marek's disease virus mutant lacking six unique short region genes 显示文摘 | Parcells M S Anderson A S Morgan T W | 1995 | J Virol1995，69，： | 1 |
| 8 | Seasonal variation and the immune response:a fish perspective显示文摘 | Bowden T J Thompson K D Morgan A L | 2007 | Fish Shellfish Immunol2007，22，6： | 1 |
| 9 | Pyrophoric nature of ironic sulfide显示文摘 | Walker RSteele A D Morgan T D B | 1996 | Ind Eng Chem Res1996，35，： | 1 |
| 10 | Beach Awards and Rating Systems 显示文摘 | WILLIAMS A T Morgan R | 1995 | Shore & Beach1995，63，4： | 1 |
| 11 | Wrist injuries in young adults: the diagnostic impact of CT and MRI显示文摘 | Fotiadou A Patel A Morgan T | 2011 | EurJ Radiol2011，77，2： | 1 |
| 12 | Jump height of overhead - lineeond - uetors after the sudden release of ice loads 显示文摘 | Morgan V T Swift D A | 1964 | Proceedings lEE1964，111，10： | 1 |
| 13 | Matrix-degrading and pro-inflammatory changes in human vascular endothelial cells exposed to cigarette smoke condensate 显示文摘 | Nordskog B K Blixt A D Morgan W T | 2003 | Cardiovasc Toxicol2003，3，： | 1 |
| 14 | Volatile lipid oxidation products of Wagyu and domestic breeds of beef显示文摘 | Boylston T D Morgan S A John K A | 1996 | Journal of Agricultural and Food Chemistry of Food and Agriculture1996，44，4： | 1 |
| 15 | Synergistic enhancement of testosterone transdermal delivery显示文摘 | Nicolazzo J A Morgan T M Reed B L | 2005 | J Cont Rel2005，103，3： | 1 |
| 16 | Effect of candesartan and lisinopril alone and in combination on blood pressure and mi- croalbuminuria显示文摘 | Morgan T Anderson A Bertram D | 2004 | J Renin Angiotensin Aldosterone Syst2004，5，2： | 1 |
| 17 | Note: tree ring respon- ses to drought across species and contrasting sites in the ridge and valley of central Pennsylvania 显示文摘 | Abrams M D Ruffner C M Morgan T A | 1998 | Forest Science1998，44，4： | 1 |
| 18 | Tales from the fields:sources of employee identification in agribusiness显示文摘 | Morgan J M Reynolds C M Nelson T J Johanningmeier A R Griffin M Andrade P | | 0，，02： | 1 |
| 19 | Characterization of molecular mass ranges of two coal tar distillate fractions (creosote and anthracene oils) and aromatic standards by LD - MS, GC - MS, probe-MS and size - exclusion chromatography显示文摘 | MORGAN T J GEORGE A LVAREZ P A | 2008 | Energy Fuels2008，22，5： | 1 |
| 20 | Flammability of polysturene layered silicate nanocomposites :Carbonaceous char formation 显示文摘 | Morgan A B Harris Jr R H T Kashiwagi T | 2002 | Fire and Materials2002，26，2： | 1 |
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