|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 3 | Simulation of moving boundary of the reaction shaft in a flash smelting furnace显示文摘As to solve the online monitoring of the inner temperatur e and freezing profile of the reaction shaft of flash smelting furnace, simulation of the wall in the reaction shaft in a flash smelting furnace was made through numerical computation. The computational results are very near the data got in s ite. The error of the moving boundary is approximately 3%, and that of the tempe rature is less than 5%. It is proved that the simulation software is applicable for practice to monitor the temperature and moving boundary inside the hearth on line. Based on a large number of the data computed, the relation between the cha nge of the moving boundary and inner temperature is summarized, and the great in fluence of the cooling system on the forming and stability of the moving boundar y inside the hearth is emphasized, which provide the theoretical bases for optim izing the flash smelting operation. | CHEN Zhuo 1,MEI Chi 1,CHEN Hong-rong 1,MO Jiao 2 (1 Institute on Simulation and Optimization of Pyro-installation, Central Sout h University, Changsha 410083, China 2 Science School, Beijing University of Posts and Telecommunications, Beijing 1 | 2001 | Journal of Central South University2001，13，3： | 3 |
| 4 | Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction显示文摘 | Manal M. Hassan Ahmed Kaseb Carol J. Etzel Hashem El‐Serag Margaret R. Spitz Ping Chang Katherine S. Hale Mei Liu Asif Rashid Mohamed Shama James L. Abbruzzese Evelyne M. Loyer Harmeet Kaur Hesham M. Hassabo Jean‐Nicolas Vauthey Curtis J. Wray Basmah S. H | 2013 | Mol Carcinog2013，，1： | 2 |
| 5 | Initial Combination Therapy Reduces the Risk of Cardiovascular Events in Hypertensive Patients: A Matched Cohort Study显示文摘 | Alan H. Gradman Hélène Parisé Patrick Lefebvre Heather Falvey Marie-Hélène Lafeuille Mei Sheng Duh | 2013 | Hypertension2013，，2： | 2 |
| 6 | Effect of MCI-154,a calcium sensitizer,on calcium sensitivity of myocardial contractile system in endotoxemic rats显示文摘 | Mei J M Hu D Y Chen H S | 2000 | Acta Pharmacol Sin2000，21，： | 2 |
| 7 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 8 | Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on focol cerebral ischemia in rats 显示文摘 | ZHANG W P WEI E Q MEI R H | 2002 | Acta Pharmacol Sin2002，23，10： | 1 |
| 9 | The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumors显示文摘 | Andersson J Sjopren H Meis -kindblom | 2002 | Am J Pathol2002，160，1： | 1 |
| 10 | Effect of Fatty Acid Addition on the Properties of Biopolymer Films Based on Lipophilic Maize Starch and Gelatin 显示文摘 | F M FAKHOURI L C B FONTES L H INNOCENTINI- MEI | 2009 | Starch-Starke2009，，61： | 1 |
| 11 | Robust visual tracking and vehicle classificationvia sparse representation显示文摘 | MEI X LING H | 2011 | IEEE Transactions on Pattern Analy-sis and Machine Intelligence2011，33，11： | 1 |
| 12 | Arrangement of phases and heating constraints in a busbar显示文摘 | Hedia H Henrotte F Meys B | 1999 | IEEE Transactions on Magnetics1999，35，3： | 1 |
| 13 | A contact mode for the effect of particle coating on improving the flowability of cohesive powders显示文摘 | MEI R SHANG H KLAUSNER J F | 1997 | Kona1997，15，： | 1 |
| 14 | Fission trakc dating of Mesozoic sandstone and its tectonic significance in the Eastern Si chuan basin, China显示文摘 | Shen C B Mei L F Xu S H | 2009 | Radiation Measurements2009，44，： | 1 |
| 15 | Physico chemistry of initial microbial adhesive interactions -Its mechanisms and methods for study 显示文摘 | Bos R Vander Mei H C Busscher H J | 1999 | FEMS Microbiology Review1999，23，2： | 1 |
| 16 | Improved paclitaxel accumulation in cell suspension cultures of Taxuschinensis by brassinolide显示文摘 | Zang X Mei X G Zhang C H | 2001 | Biotechnolo-gy Letters2001，23，： | 1 |
| 17 | A new method for obtaining ultra-low sulfur diesel fuel via ultrasound assisted oxidative desulfurization显示文摘 | MEI H MEI B W YEN T F | 2003 | Fuel2003，84，4： | 1 |
| 18 | Hybrid simulation of dynamics for the pantograph-catenary system显示文摘 | Zhang W H Mei G M Zeng J | 2002 | Vehicle System Dynamics2002，38，6： | 1 |
| 19 | Electric current-induced detachment of staphylococcus epidermidis biofilms from surgical stainless steel 显示文摘 | van der Borden A J van der Werf H van der Mei HC | 2004 | Appl Environ Microbiol2004，70，11： | 1 |
| 20 | Studies on the interaction of tricyclazole with β-cyclodextrin and human serum albumin by spectroscopy 显示文摘 | Zhang H X Huang X Mei P | 2006 | J Fluoresc2006，16，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员