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| 1 | Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus显示文摘Cardiovascular(CV) complications are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine(ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM(T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2 DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin(U-Alb), mean intimal-medial thickness(IMT) and ankle brachial index(ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA(standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Yuzo Yano Taku Tsunoda Takashi Ikawa Toshihiro Matsuo Fumihiro Ochi Yoshiki Kusunoki Masaru Tokuda Tomoyuki Katsuno Tomoya Hamaguchi Jun-ichiro Miyagawa Mitsuyoshi Namba | 2015 | World Journal of Experimental Medicine2015，5，2： | 16 |
| 2 | Pathologic complete response confirmed by surgical resection for liver metastases of gastrointestinal stromal tumor after treatment with imatinib mesylate显示文摘A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor(GIST) . Computed tomography(CT) and magnetic resonance imaging(MRI) 107 mo after the operation,revealed a cystic mass(14 cm in diameter) and a solid mass(9 cm in diameter) in the right and left lobes of the liver,respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate(IM) treatment,400 mg/day orally. Following the IM treatment for a period of 35 mo,the patient underwent partial hepatectomy(S4 + S5) . The effect of IM on the metastatic lesions was interpreted as pathologic complete response(CR) . Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported. | Seiji Suzuki Koji Sasajima Masayuki Miyamoto Hidehiro Watanabe Tadashi Yokoyama Hiroshi Maruyama Takeshi Matsutani Aimin Liu Masaru Hosone Shotaro Maeda Takashi Tajiri | 2008 | World Journal of Gastroenterology2008，14，23： | 11 |
| 3 | Doppler study of hepatic vein in cirrhotic patients:Correlation with liver dysfunction and hepatic hemodynamics显示文摘AIM: To elucidate the significance of Doppler measurements of hepatic vein in cirrhotic patients and to correlate with liver dysfunction and hepatic hemodynamics. METHODS: One hundred patients with liver cirrhosis and 60 non-cirrhotic controls were studied. Doppler waveforms were obtained from right hepatic vein and flow velocity measured during quiet respiration. Doppler measurements were also obtained from portal trunk, right portal vein and proper hepatic artery. RESULTS: Hepatic vein waveforms were classified into three classical patterns. Flat waveform was uncommon. Mean hepatic vein velocity was significantly higher in cirrhotic patients (12.7 ± 6.4 vs 5.1 ± 2.1 and 6.2 ± 3.2 cm/s; P < 0.0001). The poorer the grade of cirrhosis, the higher was the mean velocity. Maximum forward velocity was never greater than 40 cm/s in controls. Degree of ascites was found to be highly correlated with mean velocity. “Very high” group (≥ 20 cm/s) presented clinically with moderate to massive ascites. Correlations between right portal flow and mean velocity was significant (P < 0.0001, r = 0.687). CONCLUSION: Doppler waveforms of hepatic vein, which is independent of liver dysfunction, should be obtained during normal respiration. Mean hepatic vein velocity reflects the change in hepatic circulation associated with progression of liver cirrhosis. It can be used as a new parameter in the assessment of liver cirrhosis. | KC Sudhamshu Shoiichi Matsutani Hitoshi Maruyama Taro Akiike Hiromitsu Saisho | 2006 | World Journal of Gastroenterology2006，12，36： | 8 |
| 4 | Immunological effect of local ablation combined with immunotherapy on solid malignancies显示文摘Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to treatment.Furthermore,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical practice.To enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to emerge.Local ablations have considerable advantages as an alternative therapeutic option,especially its minimal invasiveness.In addition,local ablations have shown immune-regulatory effect in preclinical and clinical studies.Although the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid malignancies.This article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused ultrasound.We also discuss the value of local ablations combined with immunotherapy.Local ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated. | Yusuke Takahashi Noriyuki Matsutani Takashi Nakayama Hitoshi Dejima Hirofumi Uehara Masafumi Kawamura | 2017 | Chinese Journal of Cancer2017，36，6： | 6 |
| 5 | Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus显示文摘Atherosclerotic involvements are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis(CA) being a common risk-factor for prospective crisis of coronary artery diseases(CAD) and/or cerebral infarction(CI) in DM subjects. From another point of view, several reports have supplied augmenting proof that hepatocyte growth factor(HGF) has a physiopathological part in DM involvements. HGF has been a mesenchymal-derived polyphenic factor which modulates development, motion, and morphosis of diverse cells, and has been regarded as a humor intermediator of epithelial-mesenchymal interplays. The serum concentrations of HGF have been elevated in subjects with CAD and CI, especially during the acute phase of both disturbances. In our study with 89 type 2 DM patients, the association between serum concentrationsof HGF and risk-factors for macrovascular complicationsinclusive of CA were examined. The average of serumHGF levels in the subjects was more elevated than thereference interval. The serum HGF concentrations associated positively with both intimal-media thickness(IMT)(r = 0.24, P = 0.0248) and plaque score(r = 0.27, P =0.0126), indicating a relationship between the elevatedHGF concentrations and advancement of CA involvements. Multivariate statistical analysis accentuated thatserum concentrations of HGF would be associated inde-pendently with IMT(standardized = 0.28, P = 0.0499).The review indicates what is presently known regardingserum HGF might be a new and meaningful biomarkerof macroangiopathy in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Taku Tsunoda Yuzo Yano Tomoyuki Katsuno Tomoya Hamaguchi Jun-Ichiro Miyagawa Mitsuyoshi Namba | 2014 | World Journal of Diabetes2014，5，5： | 5 |
| 6 | Different behaviors of microbubbles in the liver: time-related quantitative analysis of two ultrasound contrast agents, Levovist and Definity 显示文摘 | Maruyama H Matsutani S Saisho H | 2004 | Ultrasound Med Biol2004，30，8： | 1 |
| 7 | Pancreatic cyst associat ed with pancreas divisum treated by laparoscopy - assisted cystgastrostomy in the intragastric approach : a case report and a review of the literature 显示文摘 | Matsutani T Sasajima K Miyamoto M | 2007 | J Laparoendosc Adv Surg Tech A2007，17，3： | 1 |
| 8 | Low loss MnZn-ferrites: Fequency dependence of minimum power losstemperature 显示文摘 | Inoue 0 Matsutani N Kugimiya K | 1993 | IEEE Trans Magn1993，29，： | 1 |
| 9 | Xeroder ma pigmentosum group C protein complex is the ini tiator of global gene nucleotide excision repair显示文摘 | Sugakawa K Ng JMY Matsutani C | 1998 | MoL Cell1998，2，2： | 1 |
| 10 | Low bias voltage dry etching of InP by inductively coupled plasma (ICP) using SiCl4/Ar显示文摘 | Koyama F Iga K | 1998 | Japanese Journal Applied Physics1998，37，： | 1 |
| 11 | Whole-genome analyses reveal genetic instability of Acetobacter pasteurianus 显示文摘 | AZUMA Y HOSOYAMA A MATSUTANI M | 2009 | Nucleic Acids Res2009，37，17： | 1 |
| 12 | Grey-scale contrast enhancement in rabbit liver with DMP115 at different acoustic power levels显示文摘 | Maruyama H Matsutani S Saisho H | 2000 | Ultrasound Med Biol2000，26，9： | 1 |
| 13 | Resistance training restores muscle sex steroid hormone steroidogenesis in ol- der men 显示文摘 | Sato K Iemitsu M Matsutani K | 2014 | FASEB J2014，28，4： | 1 |
| 14 | Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases 显示文摘 | Matsutani M Sano K Takakura K | 1997 | JNeurosurg1997，86，3： | 1 |
| 15 | Comparison of CDR3 length among thymocyte subpopulations: Impacts of MHC and BV segment on the CDR3 shortening显示文摘 | Takaji Matsutani Takehiko Ohmori Masaki Ogata Hiroyuki Soga Shigeru Kasahara Takeshi Yoshioka Ryuji Suzuki Tsunetoshi Itoh | 2006 | Molecular Immunology2006，，9： | 1 |
| 16 | Skew in T-cell receptor usage and clonal T-cell expansion in patients with chronic rejection of transplanted kidneys显示文摘 | Matsutani T Ohashi Y Yoshioka T | 2003 | Transplantation2003，75，3： | 1 |
| 17 | Sonographic shift of hypervascular liver tumor on blood pool harmonic images with definity:Time-related changes of contrast-enhanced appearance in rabbit VX2 tumor under extra-low acoustic power显示文摘 | Maruyama H Matsutani S Saisho H | 2005 | Eur J Radiol2005，56，1： | 1 |
| 18 | Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas显示文摘 | Matsutani N Yokozaki H Tahara E | 2001 | Int J Oncol2001，19，3： | 1 |
| 19 | Distinct TCRAV and TCRBV repertoire and CDR3 sequence of T lymphocytes clonally expanded in blood and GVHD lesions after human allogeneic bone marrow trans plantation显示文摘 | Hirokawa M Matsutani T Saitoh H Ichikawa Y Kawabata Y Horiuehi T | 2002 | Bone Marrow Transplant2002，30，： | 1 |
| 20 | Primary intm-cranial germ cell tumors: a clinical analysis of 153 histo- logically verified cases 显示文摘 | Matsutani M Sano K Takakum K et d | 1997 | J Neurosurg1997，86，3： | 1 |
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