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| 1 | Alternatives for large-scale production of cultured beef: A review显示文摘Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today's 2-dimensional(2D) standard technique that was used to make the first cultured hamburger. Options for efficient large-scale production of stem cells are to culture cells on microcarriers, either in suspension or in a packed bed bioreactor, or to culture aggregated cells in suspension. We discuss the pros and cons of these systems as well as the possibilities to use the systems for tissue culture. Either of the production systems needs to be optimized to achieve an efficient production of cultured beef. It is anticipated that the optimization of large-scale cell culture as performed for other stem cells can be translated into successful protocols for bovine satellite cells resulting in resource and cost efficient cultured beef. | Matilda S M Moritz Sanne E L Verbruggen Mark J Post | 2015 | Journal of Integrative Agriculture2015，14，2： | 7 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 4 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 5 | Toxicity of Benzotriazole and Benzotriazole Derivatives to Three Aquatic Species显示文摘 | David A Pillard Jeffrey S Cornell Doree L DuFresne Mark T Hernandez | 2000 | Water Research2000，，2： | 2 |
| 6 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 7 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 8 | Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance 显示文摘 | Shalom S Mark AW Hugues L | 2003 | JAC2003，51，： | 1 |
| 9 | Overview of DNA chip technology显示文摘 | BERTRAND L ASAPH A MARK S | 1998 | Molecular Breeding1998，，4： | 1 |
| 10 | A reliable technique to determine the local mechanical properties at the nanoscale for cementitious materials显示文摘 | MONDAL P SHAH S P MARKS L D | 2007 | Cement and Concrete Research2007，，37： | 1 |
| 11 | MRI-ultrasound fu- sion for guidance of targeted prostate biopsy显示文摘 | Marks L Young S Natarajan S | 2013 | Curr Opin Urol2013，23，： | 1 |
| 12 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 13 | Team leadership显示文摘 | Zaccaro S J Rittman A L Marks M A | 2002 | The Leadership Quarterly2002，12，4： | 1 |
| 14 | Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus显示文摘 | Watson L Tullus K Marks S D | 2012 | J Clin Immunol2012，32，5： | 1 |
| 15 | Real-time estimation of fundamental frequency and harmonics for active shunt power filters in aircraft electrical systems显示文摘 | ELISABETTA L PERICLE Z MARK S | 2009 | IEEE Transactions on Industrial Electronics2009，56，8： | 1 |
| 16 | Perceiving multiple affordances for objects显示文摘 | YE Lin CARDWELL W MARK L S | 2009 | Ecological Psychology2009，21，3： | 1 |
| 17 | Energy control of the pendubot 显示文摘 | ISABAELLE F ROGELIO L MARK W S | 2000 | IEEE Trans on Automatic Control2000，45，4： | 1 |
| 18 | Inter-organizational knowledge transfer:Current themes and future prospects 显示文摘 | Mark E S Marjorie A L Eric W K T | 2008 | Journal of Management Studies2008，45，4： | 1 |
| 19 | Low-sulfur specifications cause refiners to look at hydrotreating options显示文摘 | LAWRENCE L U MARK W S | 1997 | Oil & Gas1997，，12： | 1 |
| 20 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
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