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| 1 | Type 2 diabetes is associated with a worse functional outcome of ischemic stroke显示文摘AIM: To assess whether ischemic stroke severity and outcome is more adverse in patients with type 2 diabetes mellitus(T2DM). METHODS: Consecutive patients hospitalized for acute ischemic stroke between September 2010 and June 2013 were studied prospectively(n = 482; 40.2% males, age 78.8 ± 6.7 years). T2 DM was defined as self-reported T2 DM or antidiabetic treatment. Stroke severity was evaluated with the National Institutes of Health Stroke Scale(NIHSS) score at admission. The outcome was assessed with the modified Rankin scale(m RS) score at discharge and with in-hospital mortality. Adverse outcome was defined as m RS score at discharge ≥ 2 or in-hospital death. The length of hospitalization was also recorded.RESULTS: T2 DM was present in 32.2% of the study population. Patients with T2 DM had a larger waist circumference, higher serum triglyceride and glucose levels and lower serum high-density lipoprotein cholesterol levels as well as higher prevalence of hypertension, coronary heart disease and congestive heart failure than patients without T2 DM. On the other hand, diabetic patients had lower low-density lipoprotein cholesterol levels and reported smaller consumption of alcohol than non-diabetic patients. At admission, the NIHSS score did not differ between patients with and without T2DM(8.7 ± 8.8 and 8.6 ± 9.2, respectively; P = NS). At discharge, the m RS score also did not differ between the two groups(2.7 ± 2.1 and 2.7 ± 2.2 in patients with and without T2 DM, respectively; P = NS). Rates of adverse outcome were also similar in patients with and without T2DM(62.3% and 58.5%, respectively; P = NS). However, when we adjusted for the differences between patients with T2 DM and those without T2 DM in cardiovascular risk factors, T2 DM was independently associated with adverse outcome [relative risk(RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. Inhospital mortality rates did not differ between patients with T2 DM and those without T2DM(9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the difference in cardiovascular risk factors between the two groups, T2 DM was again not associated with in-hospital death. CONCLUSION: T2 DM does not appear to affect ischemic stroke severity but is independently associated with a worse functional outcome at discharge. | Konstantinos Tziomalos Marianna Spanou Stella D Bouziana Maria Papadopoulou Vasilios Giampatzis Stavroula Kostaki Vasiliki Dourliou Maria Tsopozidi Christos Savopoulos Apostolos I Hatzitolios | 2014 | World Journal of Diabetes2014，5，6： | 15 |
| 2 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 3 | 在不含酒精的脂肪肝疾病和尖锐 ischemic 击严厉和结果之间的协会显示文摘 AIM:To evaluate the association of nonalcoholic fatty liver disease(NAFLD)with acute ischemic stroke severity and in-hospital outcome.METHODS:We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Scale(NIHSS)score at admission.NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels[chronic hepatitis B or C,drug toxicity,increased alcohol consumption(>21 and>14 drinks per week in men and women,respectively),cholestatic diseases or rhabdomyolysis].The outcome was assessed with the modified Rankin scale(mRS)score at discharge and in-hospital mortality.Adverse outcome was defined as mRS score at discharge≥2.Dependency at discharge was defined as mRS score between 2 to 5.RESULTS:NAFLD was present in 7.7%of the study population.Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD(P<0.05 for both comparisons).Demographic data,the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups.At admission,the NIHSS score did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respectively;P=NS).At discharge,the mRS score did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respectively;P=NS).Rates of dependency at discharge were also similar in patients with and without NAFLD(36.8%and 55.0%,respectively;P=NS)as were the rates of adverse outcome(42.9%and58.6%,respectively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respectively;P=NS).CONCLUSION:The presence of NAFLD in patients admitted for acute ischemic stroke does not appear to be associated with more severe stroke or with worse in-hospital outcome. | Konstantinos Tziomalos Vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas Christos Savopoulos Apostolos I Hatzitolios | 2013 | World Journal of Hepatology2013，5，11： | 2 |
| 4 | The sympathetic superior cervicsl ganglia as peripheral neuroendocrine centers 显示文摘 | Cardinali D P Maria I Gejman P V | 1981 | Neu ral Transmission1981，52，： | 1 |
| 5 | Genome-wide analysis of differentially expressed genes during the early stages of tomato infection by a potyvirus显示文摘 | ALFENAS-ZERBINI P MARIA I G F(A)VARO R D | | 0，，3： | 1 |
| 6 | Evaluation of Intrinsic and Extrinsic Contributions to the Piezoelectric Properties of Pb,(Zr1-xTx) O3 Thin Films as a Function of Composition显示文摘 | Kim D J Maria J P Kingon A I | | 0，，： | 1 |
| 7 | Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML) 显示文摘 | Giovanni D P Adriano V Maria I D P | 2003 | Blood2003，101，6： | 1 |
| 8 | Generation of tsunamis by a slowly spreading uplift of the sea Floor显示文摘 | Maria I Todorovska Mihailo D Trifunac | 2001 | Soil Dynamics and Earthquake Engineering2001，21，： | 1 |
| 9 | Zirconium carbide thin films deposited by pulsed laser ablation显示文摘 | ALESSIO L D SANTAGATA A TEGHIL R ZACCAGNINO M ZACCARDO I MAROTTA V FERRO D MARIA G D | 2000 | Appl Surf Sci2000，168，14： | 1 |
| 10 | Control of the chemical structure of perhydrous coals: FTIR and Py-GC/MS investigation显示文摘 | Maria J I Jose C R Fatima L D | 2002 | Journal of Analytical and Applied Pyrolysis2002，62，1： | 1 |
| 11 | Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer显示文摘 | Maria A Kouvaraki Suzanne E Shapiro Bruno D Fornage Beth S Edeiken-Monro Steven I Sherman Rena Vassilopoulou-Sellin Jeffrey E Lee Douglas B Evans | 2003 | Surgery2003，，6： | 1 |
| 12 | Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp, in response to the deleterious changes induced by H2O2 显示文摘 | Elena G B Ana I D Maria E C | 2013 | Nat Prod2013，76，5： | 1 |
| 13 | Characterization of hsp genes in planarian stem cells显示文摘 | Maria C Paolo D Maria Emilia I | 2010 | Belgian Journal of Zoology2010，140，3： | 1 |
| 14 | Added value of Virtual Touch IQ shear wave elastography in the ul- trasound assessment of breast lesions显示文摘 | Victor I Laura Maria C Ariane D | 2014 | Eur J Radi- oi2014，83，5： | 1 |
| 15 | An electronically tunable microstrip bandpass filter using thin-film barium-strontium-titanate (BST) varactors显示文摘 | GHOSH J N D MARIA J P KINGON A I | 2005 | IEEE Trans Microwave Theory Tech2005，53，9： | 1 |
| 16 | Effect of microstructure on the thermal conductivity of hot-pressed silicon nitride materials 显示文摘 | ANGEL D P MARIA I O PILAR M | 2002 | Journal of the American Ceramic Society2002，85，1： | 1 |
| 17 | Comparison of wild and cultured gilthead sea bream (Sparus aurata); composition, appearance and seasonal variations 显示文摘 | Kriton G I Maria N Alexis I K D | 2002 | In- ternational Journal of Food Science and Technology2002，37，： | 1 |
| 18 | Aromatic polyamides with pendent acetoxybenzamide groups and thin films made therefrom 显示文摘 | Ion S Mariana D I Maria B | 2003 | European Polymer Jouranl2003，39，4： | 1 |
| 19 | High temperature stability lanthanum and zirconia- based gate dielectrics 显示文摘 | Wiccakasana D Kingon A I | 2001 | Journal of Applied Physics2001，90，7： | 1 |
| 20 | The hepatoprotective effect of putrescine against cadmium-induced acute liver injury显示文摘 | Konstantinos N T Gerorgios I P Maria D | 2004 | Archives of Toxicology2004，6，78： | 1 |
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