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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 3 | Inflammation and long-term mortality after ono-ST elevation acute coronary syndrome treated with a very early invasive strategy in 1042 consecutive patients显示文摘 | Mueller C Buettner H J Hodgson J M | 2002 | Circula-tion2002，105，： | 1 |
| 4 | Industrial Research and Development, Intangible Capital Stocks, and Firm Profit Rates 显示文摘 | Grabowski H G D C Mueller | 1978 | The Bell Journal of Economics1978，9，2： | 1 |
| 5 | Effects of ultra-marathon on circulating DNA and mRNA ex- pression of pro-and anti-apoptotic genes in mono-nuclear cells 显示文摘 | Atamaniuk J Stuhlmeier K M Vidotto C Tschan H Dossenbach-Glaninger A Mueller M | 2008 | Eur J Appl Physiol2008，104，4： | 1 |
| 6 | Treatment of metastatic carcinoid tumours using multimodality therapy of octreotide acetate, intra - arterial chemotherapy and hepatic arterial chemoembolization显示文摘 | Diaco D S Hajarizadeh H Mueller C R | 1995 | Am J Surg1995，169，： | 1 |
| 7 | Women do have an improved long-term outcome after non-ST-elevation acute coronary syndromes treated very early and predominantly with percutaneous coronary intervention:a prospective study in 1,450 consecutive patients显示文摘 | MUELLER C NEUMANN FJ ROSKAMM H | 2002 | J Am Coll Cardiol2002，40，2： | 1 |
| 8 | A simple improved velocity estimation for low-speed regions based on position measurement only显示文摘 | SuY X Zheng C H Mueller P C | 2006 | IEEE Transactions on Control Systems Technology2006，14，5： | 1 |
| 9 | Sphingosine-1-phosphate receptor type-1 agonism impairs blood dendritic cell chemotaxis and skin dendritic cell migration to lymph nodes under inflammatory conditions 显示文摘 | Gollmann G Neuwirt H Tripp CH Mueller H Konwalinka G Heufler C | 2008 | Int Immunol2008，20，7： | 1 |
| 10 | Financing a por- tfolio of projects显示文摘 | Inderst R Mueller H M Munnich F C | 2007 | The Review of Financial Studies2007，20，4： | 1 |
| 11 | NPR1 modulates crosstalk between salicylate-and jasmonate-dependent defence pathways through a novel function in the cytosol显示文摘 | SPOEL S H KOORNNEEF A CLAESSENS SMC KORZELUS J P VAN PELT J A MUELLER M J BUCHALA A J METRAUX J P BROWN R KAZZAN K VAN LOON L C DONG X N PIETERSE C M J | 2003 | Plant Cell2003，15，： | 1 |
| 12 | Critical role of monocytesto support normal B cell and diffuse large B cell lymphoma survivaland proliferation显示文摘 | Mueller C G Boix C Kwan W H ei al | 2007 | J Leukocyte Biol2007，82，9： | 1 |
| 13 | @et ak Oil spill bioremediation:Experiences,lessons and results from the Exxon Valdez oil spill Alaska显示文摘 | Pritchard P H Mueller J G Rogers J C | | 0，，2： | 1 |
| 14 | pH nanoenvironment at the surface of single melanoma cells显示文摘 | STOCK C MUELLER M KRAEHLING H | | 0，，05： | 1 |
| 15 | Displacement of estradiol from estrogen receptors by simple alkyl phenols 显示文摘 | Mueller G C Kim U H | 1978 | EndocrinolOgy1978，102，： | 1 |
| 16 | Oil spill bioremediation:Experiences,lessons and results from the Exxon Valdez oil spill Alaska显示文摘 | Pritchard P H Mueller J G Rogers J C | 1992 | Biodegradation1992，3，： | 1 |
| 17 | Malignancy in renal transplantatinn显示文摘 | Morath C Mueller M Goldschmidt H | | 0，，： | 1 |
| 18 | Insights in- to the mechanisms of fault-related folding provided by vol- umetric structural restorations using spatially varying me- chanical constraints 显示文摘 | Guzofski C A Mueller J P Shaw J H | 2009 | AAPG Bulletin2009，93，4： | 1 |
| 19 | Inflammation and long-term mortality after non-ST elevation acute coronary syndrome treated with a very early invasive strategy in 1 024 consecutive patients 显示文摘 | Mueller C Buettner H Hodgson J | 2002 | Circulation2002，105，： | 1 |
| 20 | Intraarticular expression of biologically cative interleukin 1-receptor-antagonist protein by ex vivo gene therapy 显示文摘 | Bandara G Mueller G M Evans C H | 1993 | Proc Natl Acad Sci USA1993，90，10： | 1 |
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