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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | De novo expression of intercellular adhesion molecule 1 ( ICAM-1 CD54) in pancreas cancer显示文摘 | Schwaeble W Kerlin M Meyer Zum Büschenfelde KH | | 0，，： | 2 |
| 4 | Patents cited in the scientific literature: an exploratory study of 'reverse' citation relations 显示文摘 | Glanzel W Meyer M | 2003 | Scientometrics2003，58，2： | 1 |
| 5 | Distribution, forma- tion, and molecular forms of the peptide xenin in various mammals 显示文摘 | Hamscher G Meyer H E Metzger J W | 1995 | Peptides1995，16，5： | 1 |
| 6 | Interleukin-12 requires initial CD80-mediated T-cell activation to support immune responses toward human breast and ovarian carcinoma显示文摘 | Guckel B Meyer GC Rudy W | 1999 | Cancer Gene Ther1999，6，： | 1 |
| 7 | High productivity ethanol fermentation with cross-flow membrane separation techniques for continuous cell recycling 显示文摘 | Hoffmann H Kuhlmann W Meyer H D | 1995 | Membrane Science1995，22，3： | 1 |
| 8 | Formation of colloidal of hydrous iron oxide by forced hydrolysis显示文摘 | Meyer W R Pulcinelli S H Santilli C V | 2000 | Journal of Non-Crystalline Solids2000，273，： | 1 |
| 9 | Value of dietary selenium and vitamin E for weanling swine as measured by performance and tissue selenium and glutathione peroxidase activities 显示文摘 | Meyer W R et cd | 1981 | J Anita Sci1981，52，： | 1 |
| 10 | Global land use/land cover change: Towards an integrated study显示文摘 | Turner IIB L Meyer W B Skole D L | 1994 | Ambio1994，23，1： | 1 |
| 11 | Experimental Con- tamination of a Closed Endotracheal Suction System:24h vs 72h 显示文摘 | Meyer E Schuhmacher M Ebner W | 2009 | Infection2009，37，1： | 1 |
| 12 | An MEG study of picture naming 显示文摘 | Leveh W J M Roelofs A Meyer A S | 1998 | Journal of Cognitive Neuroscience1998，10，5： | 1 |
| 13 | Institutionalized organizations: Formal structure as myth and ceremony显示文摘 | Meyer J W Rowan B | 1977 | American Journal of Sociology1977，83，2： | 1 |
| 14 | Prognostic factors inthe operative treatment of ductal pancreatic carcinoma 显示文摘 | Gebhardt C Meyer W Reichel M et ai | 2000 | Langenbecks Arch Surg2000，385，1： | 1 |
| 15 | Dependence of the electrical and optical behaviour of ITO-silver-ITO multilayers on the silver properties 显示文摘 | KLOPPEL A KRIEGSEIS W MEYER B K | 2000 | Thin Solid Films2000，365，： | 1 |
| 16 | Is determineation of exercise intensityies as percentages of VO2max or HRmax adequate?显示文摘 | Meyer T Gabriel H H W Kindermann W | 1999 | Med Sci Sports Exert1999，31，： | 1 |
| 17 | Dynamics of mitochondrial DNA evolution in animals:amplification and sequencing with conserved primers显示文摘 | Kocher T W Thomas A Meyer | 1989 | Proc Nail Acad Sci1989，86，16： | 1 |
| 18 | Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleo- tide-binding superfamily 显示文摘 | Meyers B C Dickerman A W Michelmore R W | 1999 | Plant J1999，20，： | 1 |
| 19 | Testing configurable LUT-based FPGA' s显示文摘 | Huang W K Meyer F J Chen X T | 1998 | IEEE Trans on Very Large Scale Integration Systems1998，6，2： | 1 |
| 20 | Global land-use/land-cover change:Towards an integrated study显示文摘 | Turner Ⅱ B L Meyer W B Skole D L | 1994 | Ambio1994，23，1： | 1 |
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