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	题名	作者	年代	出处	被引量
1	N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.	Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea	2008	World Journal of Gastroenterology2008，14，18：	2
2	Role of grains in protocrystalline silicon layers grown at very low substrate temperatures and studied by atomic force microscopy显示文摘	Mates T Fejfar A Drbohlav I	2002	Journal of Non-Crystalline Solids2002，，：	1
3	Thin-film media: Current and future technology显示文摘	Johnson K E Mate C M Merz J A	1996	IBM J Res Develop1996，40，：	1
4	Ultrasound -assisted treatment of pahn oil samples for the determination of copper and lead by stripping chronopotenfiometry显示文摘	Cypriano J C Matos M A C Mates R C	2008	Microchem J2008，90，：	1
5	Cystic transformation of a fi- broepitelial polyp of the renal pelvis: radiologic and pathologic findings 显示文摘	Mariscal A Mate JL Guasch I	1995	A JR Am J Roentgenol1995，164，6：	1
6	Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats显示文摘	Gomez-Amores L Mate A Revilla E	2006	Life Sci2006，78，17：	1
7	Diagnostic efficiency of sono- graphic findings of thyroid nodules in the detection of malignancy 显示文摘	Gonza'lez-Gonza'lez A Mate Valdezate A Parra Arroyo A	2010	Endocrin Nutr2010，57，6：	1
8	Detachment of a drop from an internal wall in a pulsed liquid-liquid column 显示文摘	Mate A Masbernat O Gourdon C	2000	Chem EngSci2000，55，11：	1
9	Role of CD44 in the invasiveness of glioblastoma multiforme and the noninvasiveness of meningioma: an immunohistochemistry study 显示文摘	Ariza A Lopez D Mate JL	1995	Hum Pothol1995，26，：	1
10	Activation protein21 mediates induced but not basal epidermal growth factor receptor gene expression 显示文摘	Johnson A C Murphy B A Matelis C M	2007	Mol Med2007，6，1：	1
11	The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension 显示文摘	Miguel-Carrasco JL Mate A Monserrat MT	2008	Am J Hypertens2008，21，：	1
12	iMLP: Applying multi-layer perceptrons to interval-valued data显示文摘	Roque A M Mate C ArroyoJ	2007	Neural Processing Letters2007，25，2：	1
13	CyclinD1 overexpression in non-small cell lung carcinoma:correlation with Ki67 labelling index and poor cytoplasmic differentiation显示文摘	Mate JL Ariza A Aracil C	1996	J Pathol1996，180，4：	1
14	Diagnostic efficiency of sonographic findings of thyroid nodules in the detection of malignancy显示文摘	Gonzalez-Gonzalez A Mate Valdezate A Parra Arroyo A	2010	Endocrinol Nutr2010，57，6：	1
15	Cyclin D1 over - expression in non - small cell lung carcinoma: correlation with Ki67 labelling index and poor cytoplasmic differentiation显示文摘	MATE J L ARIZA A ARACIL C	1996	J Pathol1996，180，4：	1
16	Investigation of the human disease osteogenesis imperfecta: a research-based introduc-tion to concepts and skills in biomolecular analysis 显示文摘	MATE K SIM A WEIDENHOFER J	2013	Biochemis-try and Molecular Biology Education2013，41，2：	1
17	Prediction of axillary lymph node involvement of women with invasive breast carcinama: a multivariate analysis显示文摘	Jackson J S Mates D	1998	cancer1998，83，5：	1
18	CyclinD1 overexpression in non-small cell lung carcinoma: correlation with Ki67 labeling index and poor cytoplasmic differentiation显示文摘	Mate JL Ariza A	1996	J Pathol1996，180，4：	1
19	Detachment of adrop from an internal wall in a pulsed liquid-liquidcolumn 显示文摘	Mate A Masbernat O Gourdon C	2000	Chemical Engineering Science2000，55，11：	1
20	Particles in the lower t plains of the unitedstates, Part 2: and deliquescent particles 显示文摘	Hobbs P V Bowdle D A roposphere over the high Cloud condensation nuclei mate Appl Meteor 1985 RadKe L F	1985	Cli- 24(12) :1358- 13691985，24，12：	1

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