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| 1 | Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells显示文摘AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating levels.METHODS Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake assay.RESULTS In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance. | Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti ChloéBelles Miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar | 2017 | World Journal of Diabetes2017，8，4： | 2 |
| 2 | 知证卫生决策工具之十一--查找和使用当地证据显示文摘当地证据是指来源于卫生政策或卫生项目所涉及的特定环境的证据。需要这类证据与其它形式的证据共同支持方案决择。全球证据是判断政策效果及其影响因素和深入了解问题解决办法的最佳出发点。而当地证据大多数是在判断应采纳哪些决定及采取哪些措施时使用。本文提出以下5个问题供政策制定者在识别和评价当地证据进行知证决策时参考:①知证决策需要什么样的当地证据?②如何获得必需的当地证据?③如何评价现有当地证据的质量?④当地证据的可获得性、质量或结果是否有重要变化?⑤如何整合当地证据与其他信息? | Simon Lewin Andrew D Oxman John N Lavis Atle Fretheim Sebastian Garcia Marti Susan Munabi-Babigumira 李幼平 王莉 成岚 蒋兰慧 蔡羽嘉 | 2010 | 中国循证医学杂志2010，10，4： | 2 |
| 3 | Neutron Irradiation Effects on Optical Absorption of KU1 and KS-4V Quartz Glasses and Infrasi1301显示文摘 | Leon M Marti n P Vila R | 2009 | Fusion Engineering and Design2009，84，71819110111： | 1 |
| 4 | Role of guided bone regeneration principle in preventing fibrous healing in distraction osteogenesis at high speed: experimental study in rabbit mandibles 显示文摘 | Elshahat A Inoue N Marti G | 2004 | J Craniofac Surg2004，15，6： | 1 |
| 5 | Prediction of severe communityacquired pneumonia:a systematic review and meta-analysis显示文摘 | Marti C Garin N Grosgurin O | | 0，，4： | 1 |
| 6 | Endothelialdysfunction, arterial stifTness, and heart failure显示文摘 | Marti C N Ghcorghiade M Kalogeropoulos A H | 2012 | J Am Coll Cardiol2012，60，16： | 1 |
| 7 | Comparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer 显示文摘 | Marti A Jichlinski P Lange N | 2003 | J Urol2003，170，： | 1 |
| 8 | Incidence of lymph node metastasis in elective (prophylactic) neck dissection for oral carcinoma显示文摘 | Martis C Karabouta I Lazaridis N | 1979 | J Oral Maxillofac Surg1979，7，： | 1 |
| 9 | Novel semicon-ductor solar cell structures:the quantum dot intermediate band solar cell显示文摘 | MARTI A LOPEZ N ANTOLIN E | 2006 | Thin Solid Films2006，，： | 1 |
| 10 | Prediction of severe community-acquired pneumonia:a systematic review and meta-analysis显示文摘 | Marti C Garin N Grosgurin O | 2012 | Crit Care2012，16，4： | 1 |
| 11 | Evidence from glut2 - null mice that glucose is a critical physiological regulator of feeding 显示文摘 | Bady I N Marty M Dallaporta | 2006 | Diabetes2006，55，4： | 1 |
| 12 | Role of guided bone regeneration principle in preventing fibrous healing in distraction osteogenesis at high speed:experimental study in rabbit mandibles显示文摘 | Elshahat A Inoue N Marti G | 2004 | J Craniofac Surg2004，15，6： | 1 |
| 13 | How Does Surface Wettability Influence Nucleate Boiling 显示文摘 | Phan H T N Caney P Marty | 2009 | C R Mecanique2009，337，： | 1 |
| 14 | Data clustering: a review显示文摘 | Jain A K Marty M N Flynn P J | 1999 | ACM computing surveys (CSUR)1999，31，3： | 1 |
| 15 | Surface Wet- tability Control by Nanocoating: The Effects on Pool Boiling Heat Transfer and Nucleation Mechanism 显示文摘 | Phan H T N Caney P Marty | 2009 | In- ternational Journal of Heat and Mass Transfer2009，52，2324： | 1 |
| 16 | Improved approximation of the Brinkman equation using a lattice Boltzmann method 显示文摘 | MARTYS N S | 2001 | Physics of Fluids2001，13，6： | 1 |
| 17 | Experimental analysis of the quasi-Fermi level split in quantum dot intermediate-band solar cells显示文摘 | LUQUE A MARTI A LOPEZ N | 2005 | Appl Phys Lett2005，87，8： | 1 |
| 18 | Material Spiraling in Stream Corridors:A Telescoping Ecosystem Model显示文摘 | FISHER S G GRIMM N B MARTI E | 1998 | Ecosystems1998，1，1： | 1 |
| 19 | T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17显示文摘 | Rangacari M Mauermann N Marty RR | 2006 | J Exp Med2006，203，8： | 1 |
| 20 | Produc-tion of photocurrent due to intermediate-to-conduction-band transitions:a demonstration of a key operating principle of the intermediate-band solar cell显示文摘 | MARTI A ANTOLN E STANLEY C R | 2006 | Phys Rev Lett2006，97，24： | 1 |
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