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| 1 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 2 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 3 | 利用测井曲线评价碎屑岩岩石物理参数——以埃及尼罗河三角洲El-Wastani气田上中新统为例显示文摘利用埃及尼罗河三角洲El-Wastani气田10口气井的测井数据,对该气田主要储集层上中新统Qawasim组和Abu Madi组进行岩石物理分析,利用测井参数交会图进行岩性分析,并评估泥质含量、孔隙度、含水饱和度、含油气孔隙体积等参数。分析各井中子孔隙度-密度交会图、中子孔隙度-无铀伽马交会图和岩性-饱和度交会图发现:下Abu Madi组主要为砂岩,偶夹页岩;Qawasim组主要为页岩,偶夹砂岩。利用参数交会图及无铀伽马测井结果,得到有效产层各参数的临界值分别为:泥质含量50%,孔隙度10%,含水饱和度70%。分别绘制了产层有效厚度、平均孔隙度、泥质含量、含水饱和度等参数的等值线图,综合分析发现,研究区Qawasim组和Abu Madi组碎屑岩为优质储集层,天然气有利聚集区呈北西—南东向展布,中部尤为有利。 | Ezz S El-Din Maher A Mesbah Mohamed A Kassab Ibtehal F Mohamed Burns A Cheadle Mostafa A Teama | 2013 | 石油勘探与开发2013，40，4： | 3 |
| 4 | Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target显示文摘 | Ashfaq Shuaib Ken Butcher Askar A Mohammad Maher Saqqur David S Liebeskind | 2011 | Lancet Neurology2011，，10： | 3 |
| 5 | Rapid detection of Listeria monocytogenes in food using culture enrichment combined with real-time PCR显示文摘 | Justin O’Grady Margaret Ruttledge Sara Sedano-Balbás Terry J. Smith Thomas Barry Majella Maher | 2008 | Food Microbiology2008，，1： | 2 |
| 6 | Development and characterization of a molecular viability assay for phenumocystis carrnii f sp hominis显示文摘 | Maher N Vermund S Weish D | 2001 | J Infect Dis2001，183，12： | 1 |
| 7 | Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics 显示文摘 | Lampertico P Maher J S Gerber M A | 1991 | Hepatology1991，13，3： | 1 |
| 8 | Improvement of performance and reduction of pollutant emission of a four stroke spark ignition engine fueled with hydrogen-gasoline fuel rnixture显示文摘 | SADIQ A B HAROUN A K S | 2000 | Energy Conversion & Management2000，，41： | 1 |
| 9 | Chest CT performed with Z-axis modulation: scanning protocol and radiation dose 显示文摘 | Kalra AS Rizzo S Maher MM | 2005 | Radiology2005，237，： | 1 |
| 10 | Molecular evolution of the human enteroviruses:correlation of serotype with VP1 sequence and application to picornavirus classification 显示文摘 | Oberste M S Maher K Flemister M R | 1999 | J Virol1999，73，3： | 1 |
| 11 | Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavir- us classification显示文摘 | Oberste M S Maher K Kilpatrick D R Pallansch M A | 1999 | J Virol1999，73，3： | 1 |
| 12 | Laser-target interaction near the plasma-formation threshold 显示文摘 | BAYAND S H MAHER W E HALL R B | 1980 | Journal of Applied Physics1980，51，11： | 1 |
| 13 | The effect of cardiopulmonary resuscitation training on psychological variables of cardiac rehabili- tation patients 显示文摘 | Ingram S Maher V Bennett K | 2006 | Resuscitation2006，71，1： | 1 |
| 14 | Comparison of classic and molecular approaches for the identification of untypeable enteroviruses显示文摘 | Oberste M S Maher K Flemister M R | 2000 | J Clin Microbiol2000，38，3： | 1 |
| 15 | Complete genome sequences of all members of the species Human entereovirus A 显示文摘 | OBERSTE M PENARANDA S S MAHER K | 2004 | J C en Virol2004，85，6： | 1 |
| 16 | Surface modification of polypropylene films by chitosan and chitosan/pectin multilayer显示文摘 | Maher Z E Entsar S A Khaled S A | 2008 | Science direct Carbohydrate Polymers2008，，71： | 1 |
| 17 | Chest CT per- formed with zaxis modulation: scanning protocol and ra- diation dose 显示文摘 | Kalra M K Rizzo S Maher M M | 2005 | Radiology2005，237，1： | 1 |
| 18 | Molecular epidemiology and genetic diversity of echovirus type 30 (E30):Genotypes correlate with temporal dynamics of E30 isolation显示文摘 | Oberste M S Maher K Kennett M L | | 0，，12： | 1 |
| 19 | The mycotoxin Patulin increases colonic epithelial permeability in vitro显示文摘 | Mohan H M Collins D Maher S | 2012 | Food and Chemical Toxicology2012，50，11： | 1 |
| 20 | Randomized controlled trial of neural mobilization after spinal of spinal surgery 显示文摘 | Scrimshaw S Maher C | 2001 | Spine2001，26，24： | 1 |
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