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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 3 | A new technique for determining corrosion behavior of lubricant systems显示文摘 | P J Kennedy M S Ruzansky V S Agarwala | 1989 | Corrosion1989，45，2： | 2 |
| 4 | Association study of endometriosis and intercellular adhesion mole - cule - 1 ( ICAM - 1 ) gene polymorphisms in a Japanese population显示文摘 | Yamashita M Yoshida S Kennedy S | 2005 | J Soc Gynecol Investig2005，12，4： | 1 |
| 5 | Identification of a Linear Peptide Recognized by Monoclonal Antibody 2D7 Capeble of Generating CCR5-Specific Antibodies with Human Immunodeficiency Virus-Neutralizing Activity 显示文摘 | Khurana S Kennedy M King LR | 2005 | JOURNAL OF VIROLOGY2005，，： | 1 |
| 6 | Leaf surface chemicals from Nicotiana affecting germination of Peronospora tabacina (Adam) sporangia 显示文摘 | Kennedy B S Nielsen M T Severson R F | 1992 | J Chem Ecol1992，18，： | 1 |
| 7 | Influence of transglutaminase treatment on properties of micellar casein and products made therefrom 显示文摘 | Mounsey J S O ' Kennedy B T Kelly P M | 2005 | Lait2005，85，： | 1 |
| 8 | Carrying Capacity in Agriculture: Global and Regional Issue显示文摘 | Harris J M Kennedy S | 1999 | Ecological Economics1999，29，3： | 1 |
| 9 | Develo- ping suitable colour in the gonads of cultured green sea urchins ( Strongylocentrotus droebachiensis) 显示文摘 | Robinson S M C Castell J D Kennedy E J | 2002 | Aq- uaculture2002，206，： | 1 |
| 10 | Construction of classes of circuit-independent chaotic oscillators using passive-only nonlinear devices显示文摘 | KENNEDY M P | 2001 | IEEE Transactions on Circuits and Systems-I:Fundamental Theory and Applications2001，48，： | 1 |
| 11 | Heritability of somatic cell count and its relationship with milk yield and composition in Holsteins 显示文摘 | Kennedy B W Sethar M S Moxley J E | 1982 | J Dairy Sci1982，65，： | 1 |
| 12 | Collecting duct carcinoma of the kidney显示文摘 | KENNEDY S M MERINO M J LINEHAN W M | 1990 | Hum Pathol1990，21，4： | 1 |
| 13 | Sexing birds by laparoscopy显示文摘 | Bush M Kennedy S Wildt D E | 1978 | Im Zoo Yb1978，18，： | 1 |
| 14 | Consumers' Trust of Sales-person and Manufacturer: An Empirical Study显示文摘 | Kennedy M S Ferrell L K LeClair D T | 2001 | Journal of Busi-ness Research2001，51，1： | 1 |
| 15 | Automatic linkage of vital records显示文摘 | NEWCOMBE H B KENNEDY J M AXFORD S J | | 0，，3381： | 1 |
| 16 | On the application of constitutive equation for whole human blood显示文摘 | Rodkiewicz C M Sinha P Kennedy J S | 1990 | J Bio Mechanival Engg1990，112，： | 1 |
| 17 | Displacement - based seismic design of building - theory 显示文摘 | Medhekar M S and Kennedy D J L | 2000 | Engineering Structures2000，22，3： | 1 |
| 18 | Displacement-based seismic design of buildings-theory显示文摘 | MEDHEKAR M S KENNEDY D T L | 2000 | Engineering Structures2000，22，： | 1 |
| 19 | Isolation of porcine circovirus 2 like viruses from pigs with a wasting disease in the USA and Europe 显示文摘 | Allan G M McNeilly F Kennedy S | 1998 | J Vet Diagn Invest1998，10，1： | 1 |
| 20 | Delayed coker coke morphology fundamentals:Mechanistic implication based on XPS analysis of the composition of vanadium-and nickel-containing additives during coke formation显示文摘 | KELEMEN S R SISKINM GORBATY M L FERRUGHELLI FT WIATEKPJK BROWN L D EPPIGC P KENNEDY R J | | 0，，02： | 1 |
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