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| 1 | Blood pressure gradients in cerebral arteries:a clue to pathogenesis of cerebral small vessel disease显示文摘rationale The role of hypertension in cerebral small vessel disease is poorly understood.At the base of the brain(the‘vascular centrencephalon’),short straight arteries transmit blood pressure directly to small resistance vessels;the cerebral convexity is supplied by long arteries with many branches,resulting in a drop in blood pressure.Hypertensive small vessel disease(lipohyalinosis)causes the classically described lacunar infarctions at the base of the brain;however,periventricular white matter intensities(WMIs)seen on MRI and WMI in subcortical areas over the convexity,which are often also called‘lacunes’,probably have different aetiologies.Objectives We studied pressure gradients from proximal to distal regions of the cerebral vasculature by mathematical modelling.Methods and results Blood flow/pressure equations were solved in an Anatomically Detailed Arterial Network(ADAN)model,considering a normotensive and a hypertensive case.Model parameters were suitably modified to account for structural changes in arterial vessels in the hypertensive scenario.Computations predict a marked drop in blood pressure from large and medium-sized cerebral vessels to cerebral peripheral beds.When blood pressure in the brachial artery is 192/113 mm Hg,the pressure in the small arterioles of the posterior parietal artery bed would be only 117/68 mm Hg.In the normotensive case,with blood pressure in the brachial artery of 117/75 mm Hg,the pressure in small parietal arterioles would be only 59/38 mm Hg.conclusion These findings have important implications for understanding small vessel disease.The marked pressure gradient across cerebral arteries should be taken into account when evaluating the pathogenesis of small WMIs on MRI.Hypertensive small vessel disease,affecting the arterioles at the base of the brain should be distinguished from small vessel disease in subcortical regions of the convexity and venous disease in the periventricular white matter. | Pablo J Blanco Lucas O Müller J David Spence | 2017 | Stroke & Vascular Neurology2017，2，3： | 9 |
| 2 | A practical method for calculating largest Lyapunov exponents in from small data set显示文摘 | Rosenstein M T Collins J J De Luca C J | 1993 | Physica D1993，65，12： | 2 |
| 3 | 术前检测患者血液中总蛋白、白蛋白与白细胞介素-1受体拮抗剂作为切口疝修补术后是否出现血清肿的预测指标显示文摘患者切口疝修补术后出现血清肿是非常常见的,约占20%~30%,其中10%的患者渗液量超过50ml。出现血清肿并不一定出现并发症,但血清肿患者术后容易出现疼痛不适,尤其是补片感染导致修补手术失败,切口疝复发。对某些患者及时使用细针抽液,甚至是手术治疗都是必要的。 | Klink CD Binnebosel M Lucas AH Schachtrupp A Grommes J Conze J Klinge U Neumann U Junge K 宗振(译) 陈双(校) | 2012 | 中华疝和腹壁外科杂志(电子版)2012，6，2： | 2 |
| 4 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 5 | Temperature in the box girder of the normandy bridge 显示文摘 | Lucas J M Vidogeux M Louis C | 2005 | Structural Engineering International: Journal of the International Association for Bridge and Structural Engineering ( IABSE)2005，15，3： | 1 |
| 6 | On the influence of psychrometric ambient conditions on cooling tower drift deposition 显示文摘 | LUCAS M MARTINEZ P J | 2010 | Heat and Mass Transfer2010，53，： | 1 |
| 7 | A practical method for calculating largest Lyapunov exponents from small data sets显示文摘 | ROSENSTEIN M T COLLINS J J DE LUCA C J | 1993 | Physica D1993，65，1： | 1 |
| 8 | On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘 | E G Herbert G M Pharr W C Oliver B N Lucas J L Hay | 2001 | Thin Solid Films2001，，： | 1 |
| 9 | A practical method for calculating largest lyapunov exponents from small data sets显示文摘 | Rosenstein M T Collins J J De Luca C J | 1993 | Physics D: Nonlinear Phenomena1993，65，1： | 1 |
| 10 | Vinyl sulfonate co-polymers for high-temperature filtration control of wa- ter-base muds显示文摘 | Perricone A C Enright D P Lucas J M | 1986 | SPE Drilling Engineering1986，1，5： | 1 |
| 11 | Spreadsheet Analysis and Design显示文摘 | Ronen B Palley M A Lucas H C J R | 1989 | Communications of the ACM1989，32，1： | 1 |
| 12 | Experimental Relations between Physical Structure and Mechanical Properties of a Huge Number of Drawn Poly (EthyleneTerephthalate) Yarns 显示文摘 | Heuvel H M Lucas L J | 1992 | Journal of Applied Polymer Science1992，，45： | 1 |
| 13 | Nanocrystales as destructive adsorbents for mimics of chemical warfare agents显示文摘 | Lucas E M Klabunde K J | 1999 | Nanostructured Material1999，，12： | 1 |
| 14 | Hygrothermal effects of epoxy resin 显示文摘 | Zhou J M Lucas J P | 1999 | Part I:The nature of water in epoxy polymer1999，40，： | 1 |
| 15 | Exponentially weighted mov- ing average control schemes:properties and enhancements显示文摘 | LUCAS J M SACCUCCI M S | 1990 | Technometrics1990，32，1： | 1 |
| 16 | Copper and zincin vineyards of central Portugal显示文摘 | Magalhaes M J Sequeira E M Lucas M D | 1985 | Water Air and Soil Pollution1985，26，： | 1 |
| 17 | A practical method for calculating largest Lyapunov exponents from small data sets 显示文摘 | Rosenstein M Collins J Luca C J | 2003 | Physica D2003，65，5： | 1 |
| 18 | A practical method for calculating largest Lyapunov exponents from small data sets显示文摘 | Rosenstein M T Collins J J De Luca C J | 1993 | Physica D1993，，65： | 1 |
| 19 | Inflammation and insulin resistance显示文摘 | de Luca C Olefsky J M | 2008 | FEBS Lett2008，582，1： | 1 |
| 20 | Evaluation of fluorodeoxyglucose positron emission tomography in the management of soft-tissue sarcomas显示文摘 | LUCAS J D ODOHERTY M J WONG J C | 1998 | J Bone Joint Surg Br1998，80，3： | 1 |
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