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1Mianlüe tectonic zone and Mianlüe suture zone on southern margin of Qinling-Dabie orogenic belt显示文摘The Mianle tectonic zone (Mianle zone), an ancient suture zone in addition to the Shangdan suture in the Qinling-Dabie orogenic belt, marks an important tectonic division geo-logically separating north from south and connecting east with west in China continent. To de-termine present structural geometry and kinematics in the Mianle tectonic zone and to recon-struct the formation and evolution history involving plate subduction and collision in the Qinling-Dabie orogenic belt, through a multidisciplinary study, are significant for exploring the mountain-building orogenesis of the central orogenic system and the entire process of the major Chinese continental amalgamation during the Indosinian.ZHANG Guowei1, DONG Yunpeng1, LAI Shaocong1, GUO Anlin1, MENG Qingren2, LIU Shaofeng3, CHENG Shunyou1, YAO Anping1, ZHANG Zongqing4, PEI Xianzhi5 & LI Sanzhong6 1. Department of Geology, Northwest University, Xian 710069, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China 3. Earth Science and Resource Faculty, China University of Geosciences, Beijing 100083, China 4. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China 5. Changan University, Xian 710054, China 6. Qingdao University of Oceanography, Qingdao 266003, China 2004Science China Earth Sciences2004,47,4:57
2Zircon U-Pb geochronology of basement metamorphic rocks in the Songliao Basin显示文摘Zircon LA-ICP MS U-Pb dating of six metamorphic rocks and a metagranite (breccia) from southern basement of the Songliao Basin are reported in order to constrain the formation ages of basement. The basement metamorphic rocks in the Songliao Basin mainly consist of metagabbro (L45-1), amphibolite (SN117), metarhyolitical tuff (G190), sericite (Ser) schist (N103), chlorite (Chl) schist (T5-1), biotite (Bi)-actinolite (Act)-quartz (Q) schist (Y205), and metagranite (L44-1). The cathodoluminesence (CL) images of the zircons from metagabbro (L45-1) and metagranite (L44-1) indicate that they have cores of magmatic origin and rims of metamorphic overgrowths. Their U-Pb isotopic ages are 1808±21 Ma and 1873±13 Ma, respectively. The zircons with oscillatory zoning from amphibolite (SN117) and Chl schist (T5-1), being similar to those of mafic igneous rocks, yield ages of 274 ± 3.4 Ma and 264 ± 3.2 Ma, re-spectively. The zircons from metarhyolitical tuff (G190) and Ser schist (N103) display typical magmatic growth zoning and yield ages of 424 ± 4.5 Ma and 287 ± 5.1Ma, respectively. Most of zircons from Bi-Act-Q schist (Y205) are round in shape and different in absorption degree in the CL images, implying their sedimentary detritals. U-Pb dating yield concordant ages of 427 ± 3.1Ma, 455 ± 12 Ma, 696 ± 13 Ma, 1384±62 Ma, 1649±36 Ma, 1778±18 Ma, 2450±9 Ma, 2579±10 Ma, 2793±4 Ma and 2953±14 Ma. The above-mentioned results indicate that the Precambrian crystalline basement (1808―1873 Ma) exists in the southern Songliao Basin and could be related to tectonic thrust, and that the Early Paleozoic (424―490 Ma) and Late Paleozoic magmatisms (264―292 Ma) also occur in the basin basement, which are consistent with the ages of the detrital zircons from Bi-Act-Q schist in the basement.PEI FuPing XU WenLiang YANG DeBin ZHAO QuanGuo LIU XiaoMing HU ZhaoChu 2007Chinese Science Bulletin2007,52,7:57
3Detection of serum TNF-α,IFN-γ,IL-6 and IL-8 in patients with hepatitis B显示文摘NTRODUCTIONSinceMuto[1]reportedthatTNFαandIL1wererelatedtofulminanthepatitis,thestudiesontherelationshipbetweencytokinesa...WANG Jing Yan, WANG Xue Lian and LIU Pei 1999World Journal of Gastroenterology1999,5,1:54
4Regional Tectonic Transformation in East Kunlun Orogenic Belt in Early Paleozoic: Constraints from the Geochronology and Geochemistry of Helegangnaren Alkali-feldspar Granite显示文摘The Helegangnaren feldspar granite exposed in the eastern part of East Kunlun, is characterized by high concentrations of SiO2 and alkaline, low abundances of Fe, Mg and Ca, metaluminous-weak peraluminous. Trace elements analysis shows that the granite is depleted extremely in Ba, Sr and Eu, and rich in some large-ion lithophile elements and high field strength elements. Besides, the granite has high Ga contents, the values of 104 (Ga/Al) vary from 2.50 to 2.77, which is mainly greater than the lower limit of A-type granites (2.6), and is higher than the I-and S-type granites' average (2.1 and 2.28, respectively). Rare earth element (REE) is characterized by relatively high fractionations of light REE (LREE) and heavy REE (HREE) (LREE/HREE=9.3-13.60, (La/Yb)N =10.92-18.02), pronounced negative Eu anomalies (δEu=0.08-0.13), and exhibits right-dipping gull pattern. Major elements, rare elements and trace elements features show the granite is ascribed to A-type granite and A2 subtype in tectonic genetic type. They are plotted into post-collision or within-plate area in a variety of tectonic discriminations. Geological and geochemical data comprehensively suggest that the granite is formed in a post-collision extensive tectonic setting. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) zircon U-Pb dating yields a weighted mean age of 425 Ma, belonging to Middle Silurian, which is similar to the age of the post-collision geological events in the region. The differences of magmatic rocks in formation age, rocks assemblage and rocks series systematically indicate that the regional tectonic stress regime in the East Kunlun orogenic belt experienced a major transformation from compress to extension in Middle Silurianin, and the Helegangnaren feldspar granite intruded in the early stage of tectonic transformation.LI Ruibao PEI Xianzhi LI Zhuochen SUN Yu PEI Lei CHEN Guochao CHEN Youxin LIU Chengjun WEI Fanghui 2013Acta Geologica Sinica(English Edition)2013,87,2:35
5The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers显示文摘Objective MicroR NAs(mi Rs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease(AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. Methods The expression levels of exosomal miR-135 a,-193 b, and-384 in the serum from mild cognitive impairment(MCI), dementia of Alzheimer-type(DAT), Parkinson's disease with dementia(PDD), and vascular dementia(VaD) patients were measured with a real-time quantitative reverse transcriptase PCR(qR T-PCR) method. Results Both serum exosome mi R-135 a and miR-384 were up-regulated while miR-193 b was down-regulated in serum of AD patients compared with that of normal controls. Exosome miR-384 was the best among the three miR s to discriminate AD, VaD, and PDD. Using the cut-off value could better interpret these laboratory test results than reference intervals in the AD diagnosis. ROC curve showed that the combination of mi R-135 a,-193 b, and-384 was proved to be better than a particular one for early AD diagnosis. Conclusion Our results indicated that the exosomal miR s in the serum were not only potential biomarker of AD early diagnosis, but might also provide novel insights into the screen and prevention of the disease.YANG Ting Ting LIU Chen Geng GAO Shi Chao ZHANG Yi WANG Pei Chang 2018Biomedical and Environmental Sciences2018,31,2:35
6Abnormal immunity and gene mutation in patients with severe hepatitis-B显示文摘AIM: To evaluate the abnormal immunity and gene mutation at precore 1896 site in patients with severe hepatitis-B.METHODS: This study included 23 patients with severe hepatitis-B, 22 patients with acute hepatitis-B and 20 controls.Mutation at precore 1896 site of HBV gene was confirmed with restriction fragment length polymorphism (RFLP) analysis.Cytokines including TNF-α, IFN-y, IL-6, and IL-8 were measured with ELISA, and T subgroups were detected with alkaline phosphatase anti alkaline phosphatase (APAAP) technique.RESULTS: In patients with severe hepatitis-B, the infective rate of HBV mutant strain was 52.5% (12/23), and only one patient with acute hepatitis-B was infected with the mutant strain. The percentage of CD8+ T lymphocyte was obviously lower (0.16±0.02%) and the ratio of CD4+/CD8+ was obviously higher (2.35±0.89) in mutant group than in wildtype group (0.28±0.05% and 1.31±0.18%, respectively,P<0.01 or P<0.05). The levels of cytokines in patients with severe hepatitis-B were higher (TNF-α 359.0±17.2 ng/L, IFNγ 234.7±16.5 ng/L, IL-6 347.5±31.3 ng/L, IL-8 181.1±19.6ng/L) than those in acute hepatitis-B (TNF-α 220.6±8.9ng/L, IFN-γ 174.9±12.0 ng/L, IL-6 285.8±16.5 ng/L, IL-8118.4±5.1 ng/L, P<0.01 or 0.05). In patients with severe hepatitis-B, the levels of IFN-γ and IL-6 were higher in mutant group (273.4±26.6 ng/L, 387.7±32.5 ng/L) than in wild-type group (207.8±12.8 ng/L, 300.9±16.3 ng/L). The mortality of patients infected with HBV mutant strain was higher (100%)than that with wild-type (0.9%).CONCLUSION: In severe hepatitis-B, the infective rate of HBV mutant strain was high. The mutant strain induces more severe immune disorders in host, resulting in the activation of lymphocyte and release of cytokines. HBV DNA mutates easily in response to the altered immunity. Ultimately liver damage is more prominent.Jing-Yan Wang Pei Liu Department of Infectious Diseases,the Second Hospital,China Medical University,Shenyang 110004,Liaoning Province,China 2003World Journal of Gastroenterology2003,9,9:39
7Failure behavior of a rock-coal-rock combined body with a weak coal interlayer显示文摘Using an MTS 815 testing machine,the deformation and failure behavior of a rock-coal-rock combined body containing a weak coal interlayer has been investigated and described in this paper.Uniaxial loading leads to the appearance of mixed cracks in the coal body which induce instability and lead to bursts in coal.If the mixed crack propagates at a sufficiently high speed to carry enough energy to damage the roof rock,then coal and rock bursts may occur-this is the main mechanism whereby coal bumps or coal and rock bursts occur after excavation unloading.With increasing confining pressure,the failure strength of a rock-coal-rock combined body gradually increases,and the failure mechanism of the coal interlayer also changes,from mixed crack damage under low confining pressures,to parallel crack damage under medium confining pressures,and finally to single shear crack damage or integral mixed section damage under high confining pressures.In general,it is shown that a weak coal interlayer changes the form of overall coal damage in a rock-coal-rock combined body and reduces the overall stability of a coal body.Therefore,the whole failure behavior of a rock-coal-rock combined body in large cutting height working faces is controlled by these mechanisms.Zuo Jianping Wang Zhaofeng Zhou Hongwei Pei Jianliang Liu Jianfeng 2013International Journal of Mining Science and Technology2013,23,6:32
8LA-ICP-MS zircon U-Pb dating from granitoids in southern basement of Songliao basin:Constraints on ages of the basin basement显示文摘Seven LA-ICP-MS zircon U-Pb datings from granitoids in the southern basement of the Songliao basin were done in order to constrain the ages of the basin basement. The cathodoluminescence (CL) images of the zircons from seven granitoids indicate that they are euhedral-subhedral ones with striped ab-sorption and obvious oscillatory zoning rims. The dating results show that a weighted mean 206Pb/238U age is 236±3 Ma for quartz diorite (sample No.T6-1) located in the western slope of the basin,that weighted mean 206Pb/238U ages are 319±1 Ma (2126 m) and 361±2 Ma (1994 m) for diorite (sample No.YC1-1) and granite (sample No.YC1-2) located in northern part of southeastern uplift of the basin,respectively,and that weighted mean 206Pb/238U ages are 161±5 Ma,165±2 Ma,165±1 Ma and 161±4 Ma for samples Q2-1,SN121,SN122,and SN72 granitoids located in southern part of southeastern uplift of the basin,respectively. The statistical results of ages suggest that the middle Jurassic granitoids con-stitute the main part of basement granitoids,and that the Hercynian and Indo-Sino magmatisms also occur in the basin basement. It is implied that the Songliao basin should be a rift one formed in the intracontinent or active continental margin settings in the late Mesozoic after the Middle Jurassic orogeny took place.GAO FuHong XU WenLiang YANG DeBin PEI FuPing LIU XiaoMing HU ZhaoChu 2007Science China Earth Sciences2007,50,7:31
9Clinicopathological analysis of patients with gastric cancer in 1200 cases显示文摘INTRODUCTIONGastric cancer is one of the most common fatal malignancies in the world. The prognosis is generally poor in advanced gastric cancer .The low survival is related to delayed diagnosis, metastasis and recurrence after operation .The aim of this paper was to find correlation between clinical factors was to find correlation between clinical factors and biologic behavior of gastric cancer in a series of 1200 patients undergoing surgical resection.Wei Xin Niu Xin Yu Qin Han Liu Cheng Pei Wang Surgical Department, Zhongshan Hospital, Fu Dan University Medical Center, Shanghai 200032, China 2001World Journal of Gastroenterology2001,7,2:29
10Isolation and algae-lysing characteristics of the algicidal bacterium B5显示文摘水花蕾成为了一个全球环境的问题。最近, algicidal 细菌为禁止海藻的水花蕾作为可能的代理人吸引了宽注意。在这研究, algicidal 细菌 B5 的一紧张从活性污泥被孤立。根据它的生理的特征和 16S rDNA 基因顺序的分析,它作为杆菌被识别纺锤形。它 Microcystis aeruginosa,小球藻和 Scenedesmus 上的水藻 lysing 特征被测试。结果显示出那:(1 ) algicidal 细菌 B5 是一个克否定的细菌。有 B 的 2 紧张的紧张 B5 的 16S rDNA 核苷酸顺序相同。纺锤形被到达 99.86% , B5 因此作为 B 被识别。纺锤形;(2 ) M 上的 algicidal 细菌 B5 的海藻细胞溶解的效果。aeruginosa,小球藻和 Scenedesmus 是显著的。起始的细菌、海藻的房间密度强烈影响叶绿素的移动率 -- 一。越大起始的细菌的细胞密度,越 faster 叶绿素的降级 -- 一。越大起始的海藻的房间密度,越 slower 叶绿素的降级 -- 一。当细菌的细胞密度是 3.6 fi 时 107 cells/ml,将近 90% 叶绿素 -- 一被移开。什么时候叶绿素 -- 集中是不到 550 μ g /L,大约 70% 被移开;(3 ) 由 secreting 代谢物和这些代谢物的紧张 B5 lysed 水藻能忍受热处理。MU Rui-min FAN Zheng-qiu PEI Hai-yan YUAN Xue-liang Liu Si-xiu WANG Xiang-rong 2007Journal of Environmental Sciences2007,19,11:29
11Additive manufacturing of metals:Microstructure evolution and multistage control显示文摘As a revolutionary industrial technology,additive manufacturing creates objects by adding materials layer by layer and hence can fabricate customized components with an unprecedented degree of freedom.For metallic materials,unique hierarchical microstructures are constructed during additive manufacturing,which endow them with numerous excellent properties.To take full advantage of additive manufacturing,an in-depth understanding of the microstructure evolution mechanism is required.To this end,this review explores the fundamental procedures of additive manufacturing,that is,the formation and binding of melt pools.A comprehensive processing map is proposed that integrates melt pool energy-and geometry-related process parameters together.Based on it,additively manufactured microstructures are developed during and after the solidification of constituent melt pool.The solidification structures are composed of primary columnar grains and fine secondary phases that form along the grain boundaries.The post-solidification structures include submicron scale dislocation cells stemming from internal residual stress and nanoscale precipitates induced by intrinsic heat treatment during cyclic heating of adjacent melt pool.Based on solidification and dislocation theories,the formation mechanisms of the multistage microstructures are thoroughly analyzed,and accordingly,multistage control methods are proposed.In addition,the underlying atomic scale structural features are briefly discussed.Furthermore,microstructure design for additive manufacturing through adjustment of process parameters and alloy composition is addressed to fulfill the great potential of the technique.This review not only builds a solid microstructural framework for metallic materials produced by additive manufacturing but also provides a promising guideline to adjust their mechanical properties.Zhiyuan Liu Dandan Zhao Pei Wang Ming Yan Can Yang Zhangwei Chen Jian Lu Zhaoping Lu 2022Journal of Materials Science & Technology2022,,5:27
12BMPs functionally replace KLf4, and support efficient reprogramming of mouse fibroblasts by Oct4 alone显示文摘由定义因素的导致的 pluripotent 干细胞的产生成为了一个有用模型调查 reprogramming 和房间命运决心的机制。然而,基于因素的 reprogramming 的精确机制仍然保持不清楚。这里,我们证明 Klf4 主要在 reprogramming 的起始的阶段行动开始 mesenchymal-to-epithelial 转变并且能是机能上地由骨头代替了形态基因的蛋白质(BMP ) 。BMP 增加了老鼠的 Oct4/Sox2-mediated reprogramming 的效率胚胎的成纤维细胞(MEF ) 到 ~1% 。BMP 也支持了 MEF 和尾巴的单个因素的基于 Oct4 的 reprogramming 胫骨的成纤维细胞。我们的研究在 reprogramming 澄清 Klf4 的贡献并且在区分的房间作为 pluripotency 的单个 setter 建立 Oct4。Jiekai Chen Jing Liu Jiaqi Yang You Chen Jing Chen Su Ni Hong Song Lingwen Zeng Ke Ding Duanqing Pei 2011Cell Research2011,21,1:26
13Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang 2013Cell Research2013,23,8:26
14Effect of an Alien Species Spartina alterniflora Loisel on Biogeochemical Processes of Intertidal Ecosystem in the Jiangsu Coastal Region,China显示文摘Spartina alterniflora Loisel,生长在的种内部沿着美国的东方海岸的潮汐的公寓,几乎 30 年以前在中国被介绍并且在中国的沿海的地区由于它的侵略海角成为了一个迫切话题。这相异的种类 S 的影响。alterniflora 在上内部在江苏沿海岸地区的潮汐的生态系统过程被在更早是一座泥公寓的四年的旧 Spartina 盐沼的一座泥公寓和那些比较沉积营养素可获得性和踪迹元素集中特征调查。在每个学习地点,十五个阴谋在不同季节被取样沿着潮汐的公寓决定沉积特征。结果建议有的 Spartina 盐沼沉积更高显著地总计 N,可得到的 P,和含水量,但是比泥公寓沉积降低 pH 和体积密度。沉积咸度,含水量,全部的 N,器官的 C,和可得到的 P 在 Spartina 盐沼沿着一个朝海的方向坡度减少了并且与植被生物资源增加了。而且,尽管这些增加不是重要的,踪迹元素的集中和在沉积的一些金属元素在 Spartina 下面是更高的。在 Spartina 沼泽地,另外,某重金属在沉积的表面层被集中。在这研究的 Spartina 盐沼仅仅是四岁;因此,在江苏沿海岸地区在很长时间框架上推进这相异的种的学习,这被建议应该被执行。ZHOU Hong-Xia LIU Jin-E ZHOU Jun QIN Pei 2008Pedosphere2008,18,1:24
15SHRIMP U-Pb zircon dating for lamprophyre from Liaodong Peninsula: Constraints on the initial time of Mesozoic lithosphere thinning beneath eastern China显示文摘It is undebated fact that the lithospheric mantle beneath eastern China was considerably thinned during the Mesozoic time. However, it has no adequate evidence for the exact timing when the lithosphere thinning started. The Liaodong Peninsula is located in the eastern segment of the North China Craton and is one of the important domains to explore the event of lithosphere thinning. SHRIMP U-Pb zircon dating and geochemical study were carried out for the lamprophyre dike swarm that intruded into the magnesite ore-beds in the Dashiqiao Formation of Paleoproterozoic Liaohe Group at the Huaziyu magnesite ore district, Liaodong Peninsula. The results indicate that these lampro- phyre dikes were intruded in late Jurassic (155±4 Ma) and show some geochemical characteristics of potassic magmas. It is now accepted that the lithosphere thinning took place in the late Mesozoic, and the peak thinning stage occurred in early Cretaceous (130―120 Ma). Considering the potassic mafic magmatism marking the onset of the lithospheric thin- ning, we therefore suggest that the studied late Jurassic potassic lamprophyre dike swarm could imply that the late Jurassic is the time that lithosphere thinning started.JIANG Yaohui JIANG Shaoyong ZHAO Kuidong NI Pei LING Hongfei LIU Dunyi 2005Chinese Science Bulletin2005,50,22:22
16Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie 2011Cell Research2011,21,10:23
17Cervical Infection of Oncogenic Human Papillomavirus(HPV) Types in Beijing,China显示文摘Objective This study was designed to determine the prevalence of oncogenic human papillomavirus(HPV) in cervical infections in Beijing,China,and to investigate the odds ratio(OR) of HPV single and multiple infections in abnormal cytology.Methods A total of 19,018 specimens from outpatients in the department of obstetric and gynecology were collected.They were detected using high-risk HPV genotyping real-time polymerase chain reaction(PCR) kit and analyzed by ThinP rep cytology test for cervical pathological diagnosis.HPV prevalence,age-specific prevalence,and OR of each type of HPV in abnormal cytology were analyzed.Results Overall,19.1%(3,623/19,018) of the individuals were positive for HPV infection,14.9%(2,833/19,018) were positive for a single HPV type,and 4.2%(790/19,018) were positive for multiple types.Among the 3,623 HPV-positive individuals,the most predominant HPV types were HPV52(4.4%,834/19,018),HPV16(3.7%,710/19,018),and HPV58(3.4%,644/19,018).The OR of multiple infections and single infection differed significantly among disease severities.The OR of dual infection was higher than that of each of the two single infection types,respectively.Conclusion HPV prevalence in the outpatients was 19.1%,and the most predominant HPV types in the study were HPV52,HPV16,and HPV58.Women with multiple infectionswere more likely to have abnormal cytology.LI Ying HUANG Ke JI Pei Li SONG Lei LIU Hong Tu 2016Biomedical and Environmental Sciences2016,29,10:22
18Study on the creep permeability of mining-cracked N2 laterite as the key aquifuge for preserving water resources in Northwestern China显示文摘Wenping Li Qiqing Wang Shiliang Liu Yabing Pei 2018International Journal of Coal Science & Technology2018,5,3:22
19Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 层次调整多重生物功能的一些短 RNA,例如 tumorigenic 过程,煽动性的损害和房间 apoptosis。(ZEB1 ) 锌手指电子盒子有约束力的 homeobox 因素 1 是上皮间充质的转变(EMT ) 的一个关键调停人。它包括人的食道的有鳞房间的癌(ESCC ) 导致各种各样的癌症的恶意的前进。在这研究,我们发现 miR-128-3p 由使用 PCR 是在 ESCC 纸巾和房间的 downregulated。而且, miR-128-3p 的下面调整的表示被证明与 ESCC 病人的差的预后被联系并且可能被认为是一个独立预示的因素。然后,我们在 ESCC 房间检验了 miR-128-3p 的角色,并且发现 miR-128-3p 能在 vitro 压制房间迁居和侵略。而且, ZEB1 被证实是由酶记者试金的 miR-128-3p 的一个直接目标。营救实验证明 EMT 被 miR-128-3p 经由 ZEB1 的抑制调整。一起拿所有,我们断定 miR-128-3p 压制 EMT,经由 ZEB1 的转移,和 miR-128-3p 可以是在 ESCC 的一个批评调停人。Lili Zhao Rui Li Shanling Xu Yi Li Pei Zhao Wei Dong Zhenjun Liu Qian Zhao Bo Tan 2018Acta Biochimica et Biophysica Sinica2018,50,2:21
20High serum interleukin-6 level is associated with increased risk of delirium in elderly patients after noncardiac surgery: a prospective cohort study显示文摘LIU Pei LI Ya-wei WANG Xiao-shan ZOU Xi ZHANG Da-zhi WANG Dong-xin LI Shi-zhong 2013Chinese Medical Journal2013,,19:20
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