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| 1 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 2 | Ultrasensitive skin‐like wearable optical sensors based on glass micro/nanofibers显示文摘Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological interfaces.While electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC currents.Herein,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic skins.Electromagnetic interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are realized.Moreover,a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated.These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins. | Lei Zhang Jing Pan Zhang Zhang Hao Wu Ni Yao Dawei Cai Yingxin Xu Jin Zhang Guofei Sun Liqiang Wang Weidong Geng Wenguang Jin Wei Fang Dawei Di Limin Tong | 2020 | Opto-Electronic Advances2020，3，3： | 12 |
| 3 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 4 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 5 | The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury显示文摘充分位于调停房间的暴发性的肝炎不是的 T 下面的机制理解。在这研究,我们调查了 myeloid 是否导出房间(MDSC ) 能阻止的 suppressor concanavalin A (ConA ) 通过压制 T 房间增长导致了肝炎。我们在 ConA 治疗的早舞台在老鼠怒气和肝在 MDSC 的频率观察了增加,含有 MDSC 可能对调停 ConA 的发炎涉及老鼠的起始的抵抗。Subpopulation 分析证明在导致 ConA 的老鼠的肝的 MDSC 主要是 granulocytic MDSC。骨头的采纳转移进对待 ConA 的老鼠的导出髓的 MDSC 证明 MDSC 移居了进他们通过 ROS 压制了 T 房间增长的肝和怒气小径。另外,在老鼠的 MDSC 的频率被处理显著地也与有免疫力的 suppressor glucocorticoids 增加。进规章的 T 房间(Treg ) 的 MDSC 的转移弄空老鼠证明导致 ConA 的肝炎上的 MDSC 的保护的效果是 Treg 独立的。在结论,我们的结果证明 MDSC 在 T 调停房间的肝炎拥有一个直接保护的角色,并且由采纳转移或 glucocorticoid 治疗增加 MDSC 的频率为急性煽动性的疾病代表潜在的基于房间的治疗学的策略。 | Wenli Diao Fangfang Jin Bing Wang Chen-Yu Zhang Jiangning Chen Ke Zen Limin Li | 2014 | Protein & Cell2014，5，9： | 7 |
| 6 | Structural effects of three-dimensional angle-interlock woven composite undergoing bending cyclic loading显示文摘This paper reports the structural effects of three-dimensional(3-D)angle-interlock woven composite(3DAWC)undergoing three-point bending cyclic loading from experimental and finite element analysis(FEA)approaches.In experiment,the fatigue tests were conducted to measure the bending deflection and to observe the damage morphologies.By the FEA approach,a micro-structural unit-cell model of the 3DAWC was established at the yarn level to simulate the fatigue damage.The stress degradation at the loading condition of constant deformation amplitude was calculated to show the degradation of mechanical properties.In addition,the stress distribution,fatigue damage evolution and critical damage regions were also obtained to qualitatively reveal the structural effects and damage mechanisms of the 3DAWC subjected to three-point bending cyclic loading. | JIN LiMin YAO Yao YU YiMin ROTICH Gideon SUN BaoZhong GU BoHong | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 5 |
| 7 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 8 | Two-dimensional gel electrophoresis-based analysis provides global insights into the cotton ovule and fiber proteomes显示文摘Proteomic analysis of upland cotton was performed to profile the global detectable proteomes of ovules and fibers using two-dimensional electrophoresis(2DE).A total of 1,203 independent protein spots were collected from representative 2DE gels,which were digested with trypsin and identified by matrix-assisted laser desorption and ionization-time-offlight/time-of-flight(MALDI-TOF/TOF)mass spectrometry.The mass spectrometry or tandem mass spectrometry(MS or MS/MS)data were then searched against a local database constructed from Gossypium hirsutum genome sequences,resulting in successful identification of 975 protein spots(411 for ovules and 564 for fibers).Functional annotation analysis of the 975identified proteins revealed that ovule-specific proteins were mainly enriched in functions related to fatty acid elongation,sulfur amino acid metabolism and post-replication repair,while fiber-specific proteins were enriched in functions related to root hair elongation,galactose metabolism and D-xylose metabolic processes.Further annotation analysis of the most abundant protein spots showed that 28.96%of the total proteins in the ovule were mainly located in the Golgi apparatus,endoplasmic reticulum,mitochondrion and ribosome,whereas in fibers,27.02%of the total proteins were located in the cytoskeleton,nuclear envelope and cell wall.Quantitative real-time polymerase chain reaction(q RT-PCR)analyses of the ovule-specific protein spots P61,P93 and P198 and fiber-specific protein spots 230,477 and 511 were performed to validate the proteomics data.Protein-protein interaction network analyses revealed very different network cluster patterns between ovules and fibers.This work provides the largest protein identification dataset of 2DE-detectable proteins in cotton ovules and fibers and indicates potentially important roles of tissue-specific proteins,thus providing insights into the cotton ovule and fiber proteomes on a global scale. | Xiang Jin Limin Wang Liping He Weiqiang Feng Xuchu Wang | 2016 | Science China(Life Sciences)2016，59，2： | 3 |
| 9 | Temperature dependence of niobium superconducting nanowire single-photon detectors in He-3 cryocooler显示文摘Performances of superconducting nanowire single-photon detectors(SNSPDs) based on low TCmaterials strongly depend on the operating temperatures. We have fabricated infrared-sensitive niobium SNSPDs based on doped niobium(Nb*) films and measured them in He-3cryocooler. The critical current approaches to the de-pairing current at 0.3 K. Therefore, with the decrease in temperatures, we have observed a monotonous increase of count rate at the wavelength of 1,521 nm and exponential decrease of dark count rate at all bias currents. The possible origin of dark counts for doped Nb devices is also discussed. | Tao Jia Chao Wan Limin Zhao Yu Zhou Qingyuan Zhao Min Gu Xiaoqing Jia Labao Zhang Biaobing Jin Jian Chen Lin Kang | 2014 | Chinese Science Bulletin2014，59，28： | 2 |
| 10 | Estimation of dry deposition fluxes of major inorganic species by canopy throughfall approach显示文摘Dry deposition in China has not yet been intensively studied even though it constitutes an important pathway for acid deposition. The total deposition was monitored at Tieshanping catchment, a regional remote site in Chongqing City. The dry deposition loads of sulphur, calcium and nitrogen are estimated by using a canopy throughfall approach. The results indicate that the annual dry deposition loads of sulphur and calcium at Tieshanping site are much higher than those measured in forestry areas in other countries, while the dry deposition flux of ni- trogen is at a comparable level. The dry deposition loads of sulphur, calcium and nitrogen are all higher than the wet deposition loads. Applying a canopy budget model has proven that the routine, simplified canopy throughfall approach may underestimate the dry deposition flux of nitrogen-containing species. | JIN Lei SHAO Min ZENG Limin ZHAO Dawei TANG Dagang | 2006 | Chinese Science Bulletin2006，51，15： | 2 |
| 11 | Development of fluorine-substituted NH_(2)-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors:Boosting the safety and metabolic stability显示文摘Our recent studies for nonnucleoside reverse transcriptase inhibitors identified a highly potent compound JK-4b against WT HIV-1(EC_(50)=1.0 nmol/L),but the poor metabolic stability in human liver microsomes(t_(1/2)=14.6 min)and insufficient selectivity(SI=2059)with high cytotoxicity(CC_(50)=2.08μmol/L)remained major issues associated with JK-4b.The present efforts were devoted to the introduction of fluorine into the biphenyl ring of JK-4b,leading to the discovery of a novel series of fluorine-substituted NH_(2)-biphenyl-diarylpyrimidines with noticeable inhibitory activity toward WT HIV-1 strain(EC_(50)=1.8–349 nmol/L).The best compound 5t in this collection(EC_(50)=1.8 nmol/L,CC_(50)=117μmol/L)was 32-fold in selectivity(SI=66,443)compared to JK-4b and showed remarkable potency toward clinically multiple mutant strains,such as L100I,K103N,E138K,and Y181C.The metabolic stability of 5t was also significantly improved(t_(1/2)=74.52 min),approximately 5-fold higher than JK-4b in human liver microsomes(t_(1/2)=14.6 min).Also,5t possessed good stability in both human and monkey plasma.No significant in vitro inhibition effect toward CYP enzyme and hERG was observed.The single-dose acute toxicity test did not induce mice death or obvious pathological damage.These findings pave the way for further development of 5t as a drug candidate. | Xin Jin Shuai Wang Limin Zhao Wenjuan Huang Yinxiang Zhang Christophe Pannecouque Erik De Clercq Ge Meng Huri Piao Fener Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 12 | Long-gauge length embedded fiber optic ultrasonic sensor for large-scale concrete structures显示文摘 | Yuan libo Zhou Limin Jin Wei | 2004 | Optics & Laser Technology2004，36，1： | 1 |
| 13 | Altered expression of gene involved in hepatic morphogenesis and fibrogenesis are identified by cDNA micro-array analysis in biliary atresia显示文摘 | Andrew G Jin S | 2003 | Hepatology2003，38，： | 1 |
| 14 | Interfacial debond of shape memory alloy composites显示文摘 | Poon Chi-kin Zhou Limin Jin Wei Shi Sanqiang | 2005 | Smart Materials and Structures2005，14，4： | 1 |
| 15 | Fiber Optical Differential Interferometer显示文摘 | Yuan Libo Zhou Limin Jin Wei | 2000 | IEEE Transactions on Instrumentation and Measurement2000，49，4： | 1 |
| 16 | Long-gauge length embedded fiber optic ultrasonic sensor for large-scale concrete structures显示文摘 | Yuan Libo Zhou Limin Jin Wei | 2004 | Optics & Laser Technology2004，36，1： | 1 |
| 17 | Detection of acoustic emission in structure using sagnac like fiber loop interferometer显示文摘 | YUAN LIBO ZHOU LIMIN JIN WEI | 2005 | Sensors and Actuators A: Physical2005，118，1： | 1 |
| 18 | How double ridges and furrows mulched with plastic film affect soil water, soil temperature and yield of maize on the semiarid Loess Plateau of China显示文摘 | Zhou Limin Li Fengmin Jin Shengli | 2009 | Field Crops Research2009，113，1： | 1 |
| 19 | A Yeast BiFC-seq Method for Genome-wide Interactome Mapping显示文摘Genome-wide physical protein±protein interaction(PPI)mapping remains a major challenge for current technologies.Here,we reported a high-efficiency BiFC-seq method,yeastenhanced green fluorescent protein-based bimolecular fluorescence complementation(y EGFPBiFC)coupled with next-generation DNA sequencing,for interactome mapping.We first applied y EGFP-BiFC method to systematically investigate an intraviral network of the Ebola virus.Two-thirds(9/14)of known interactions of EBOV were recaptured,and five novel interactions were discovered.Next,we used the BiFC-seq method to map the interactome of the tumor protein p53.We identified 97 interactors of p53,more than three-quarters of which were novel.Furthermore,in a more complex background,we screened potential interactors by pooling two BiFC libraries together and revealed a network of 229 interactions among 205 proteins.These results show that BiFC-seq is a highly sensitive,rapid,and economical method for genome-wide interactome mapping. | Limin Shang Yuehui Zhang Yuchen Liu Chaozhi Jin Yanzhi Yuan Chunyan Tian Ming Ni Xiaochen Bo Li Zhang Dong Li Fuchu He Jian Wang | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 1 |
| 20 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 1 |
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