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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 3 | Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase显示文摘The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2(COX-2) and 5-lipoxygenase(5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo.The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis. | Lawrence M Knab Paul J Grippo David J Bentrem | 2014 | World Journal of Gastroenterology2014，20，31： | 9 |
| 4 | Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study显示文摘 | Maarten J Titulaer Lindsey McCracken I?igo Gabilondo Thaís Armangué Carol Glaser Takahiro Iizuka Lawrence S Honig Susanne M Benseler Izumi Kawachi Eugenia Martinez-Hernandez Esther Aguilar Núria Gresa-Arribas Nicole Ryan-Florance Abiguei Torrents Albert S | 2013 | Lancet Neurology2013，，2： | 2 |
| 5 | Microemulsion-based media as novel drug delivery systems 显示文摘 | Lawrence M J Rees G D | 2000 | Advanced Drug Delivery Reviews2000，45，1： | 1 |
| 6 | Microscale and molecular assessment of impacts of nickel,nutrients,and oxygen level on structure and function of river biofilm communities显示文摘 | Lawrence J R Chenier M R Roy R | 2004 | Applied and Environmental Microbiology2004，70，7： | 1 |
| 7 | Microemulsion-based media as novel drug delivery systems显示文摘 | LAWRENCE M J REES G D | 2000 | Adv Drug Deliv Rev2000，45，： | 1 |
| 8 | Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes显示文摘 | Dodds P N Lawrence G J Catanzariti A M | 2006 | Proc Natl Acad Sci USA2006，103，： | 1 |
| 9 | Effects of dynamic exer- cise intensity on the activation of hormone-sensitive lipase in human skeletal muscle 显示文摘 | Watt M J George JF Lawrence L | 2003 | J Physiol2003，547，1： | 1 |
| 10 | Photodechlorination of PCB's in the presence of titanium dioxide in aquenous suspensions显示文摘 | Carey J H Lawrence J Tosine H M | 1976 | Bulletin of Environmental Contamination & Toxicology1976，16，6： | 1 |
| 11 | The Melampsora lini AvrL567 avirulence genes are expressed in haustoria and their products are recognized inside plant cells 显示文摘 | Dodds P N Lawrence G J Catanzariti A M | 2004 | The Plant Cell2004，16，： | 1 |
| 12 | Toxic moieties in ruminal and duodenal digesta and in milk, and hepatic integrity in cattle given diets based on rapeseed meals of different glucosinolate con tents either untreated or treated with heat or formaldehyde显示文摘 | Subuh A M H Rowa T G Lawrence T L J | 1995 | Animal Feed Science and Technology1995，52，： | 1 |
| 13 | Allelie association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness 显示文摘 | Doull I J Lawrence S Watson M | 1996 | Am J Respir Grit Care Med1996，153，4： | 1 |
| 14 | Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intetwertebral disc 显示文摘 | Lawrence M Andrew B Carter J | 2006 | Eur Spine J2006，3，： | 1 |
| 15 | Non-ionic oil-in-water mieroemulsions: The effect of oil type on phase behaviour 显示文摘 | Warisnoicharoen W Lansley A B Lawrence M J | 2000 | lnt J Pharm2000，198，： | 1 |
| 16 | Heter-duplex molecules formed between allelic sequences cause nonparental RAPD bands显示文摘 | Aylifle M A Lawrence G J Ellis J G | 1994 | Nucleic Acid Res1994，22，： | 1 |
| 17 | Allelic association of gene mairkers on chromosomes 5q and 11 q with atopy and bronchial hyperresponsiyeness 显示文摘 | DOULL J M LAWRENCE S WATON M | 1996 | AMJ Respir Critcare Med1996，153，： | 1 |
| 18 | Haustorially expressed secreted proteins from flax rust are highly enriched for avirulence elicitors显示文摘 | Catanzariti A M Dodds P N Lawrence G J | 2006 | Plant Cell2006，18，： | 1 |
| 19 | Massage for perioperative pain and anxiety in placement of vascular access devices 显示文摘 | Rosen J Lawrence R Bouchard M et ai | 2013 | Adv Mind Body Med2013，27，1： | 1 |
| 20 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
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