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| 1 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 2 | Therapies targeting cancer stem cells: Current trends and future challenges显示文摘Traditional therapies against cancer, chemo- and radiotherapy, have multiple limitations that lead to treatment failure and cancer recurrence. These limitations are related to systemic and local toxicity, while treatment failure and cancer relapse are due to drug resistance and self-renewal, properties of a small population of tumor cells called cancer stem cells(CSCs). These cells are involved in cancer initiation, maintenance, metastasis and recurrence. Therefore, in order to develop efficient treatments that can induce a longlasting clinical response preventing tumor relapse it is important to develop drugs that can specifically target and eliminate CSCs. Recent identification of surface markers and understanding of molecular feature associated with CSC phenotype helped with the design of effective treatments. In this review we discuss targeting surface biomarkers, signaling pathways that regulate CSCs self-renewal and differentiation, drug-efflux pumps involved in apoptosis resistance, microenvironmental signals that sustain CSCs growth, manipulation of mi RNA expression, and induction of CSCs apoptosis and differentiation, with specific aim to hamper CSCs regeneration and cancer relapse. Some of these agents are under evaluation in preclinical and clinical studies, most of them for using in combination with traditional therapies. The combined therapy using conventional anticancer drugs with CSCs-targeting agents, may offer a promising strategy for management and eradication of different types of cancers. | Denisa L Dragu Laura G Necula Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2015 | World Journal of Stem Cells2015，7，9： | 10 |
| 3 | Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature显示文摘AIM:To critically review and summarize the literature on nutritional and health outcomes of semi-elemental formulations on various nutritionally vulnerable patient populations who are unable to achieve adequate nutrition from standard oral diets.METHODS:We conducted a comprehensive literature search of Pubmed and Embase databases.We manually screened articles that examined nutritional and health outcomes(e.g.,growth,disease activity,gastrointestinal impairment,mortality,and economic impact)among various patient groups receiving semi-elemental diets.This review focused on full-text articles of randomized controlled clinical trials and other intervention studies,but pertinent abstracts and case studies were also included.Results pertaining primarily to tolerance,digestion,and absorption were summarized for each patient population in this systematic review.RESULTS:Results pertaining primarily to tolerance,digestion,and absorption were summarized for each patient population.The efficacy of semi-elemental whey hydrolyzed protein(WHP)diet have been reported in various nutritionally high risk patient populations including-Crohn’s disease,short bowel syndrome,acute and chronic pancreatitis,cerebral palsy,cystic fibrosis,cerebrovascular accidents,human immunodeficiency virus,critically ill,and geriatrics.Collectively,the evidence from the medical literature indicates that feeding with a semi-elemental diet performs as well or better than parenteral or amino acid based diets in terms of toler-ance,digestion,and nutrient assimilation measures across various disease conditions.CONCLUSION:Based on this comprehensive review of the literature,patient populations who have difficulty digesting or absorbing standard diets may be able to achieve improved health and nutritional outcomes through the use of semi-elemental WHP diets. | Dominik D Alexander Lauren C Bylsma Laura Elkayam Douglas L Nguyen | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 3 |
| 4 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 5 | Low-Reynolds-Number separation on a airfoil显示文摘 | MUTI L J C LAURA P L | 1996 | AIAA Journal1996，34，8： | 1 |
| 6 | Palladium( I1 ) and Platinum( II ) Organometallic Complexes with the Model Nucleobase Anions of Thymine, Uracil, and Cytosine: Antitumor Activity and Interactions with DNA of the Platinum Compounds 显示文摘 | Jos6 R Julia L Laura S C | 2006 | Journal of In- organic Chemistry2006，45，16： | 1 |
| 7 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 8 | A study of the retrograda- tion process in five argentine rice starches显示文摘 | LAURA B I de MISHIMA B L MARIA C A | 2010 | LWT-Food Science and Technology2010，43，4： | 1 |
| 9 | Assessment of size reduction as a preliminary step in the production of ethanol from lignocellulosic wastes显示文摘 | Laura C López G D | 1989 | Biological Wastes1989，30，2： | 1 |
| 10 | Journal o{ Inorganic Biochemistry 显示文摘 | Wolfhardt F Loria M Alessandra C Chiara B Keith F T Wolf gang L Laura El C | 2008 | 102 13292008，102，： | 1 |
| 11 | PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C显示文摘 | Laura M Luca L Filippo C | 2005 | Mol Cell Biol2005，25，6： | 1 |
| 12 | Methanogens : a window into ancient sulfur metabolism 显示文摘 | Liu Y C Laura L B William B | 2012 | Trends in Microbiology May2012，21，5： | 1 |
| 13 | Differential mobilization of P in the maize rhizosphere by citric acid and potassium citrate 显示文摘 | Laura P Norbert C Jones D L | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 14 | Effects of selected armaceutical products on phagocytic activity in Elliptio complanata mussels显示文摘 | Laura C Caterina C Lucia C L | 2007 | Comp Biochem and Phys C2007，145，： | 1 |
| 15 | The Upper Carboniferous postglaeial transgression in the Paganzo and Rioblanco basins (northwestern Argentina): Facies and stratigraphie significance 显示文摘 | Carlos O L Silvia N C Laura I N | 2002 | Journal of South American Earth Sciences2002，15，： | 1 |
| 16 | Impacts of a thermal power plant on the phosphorus TMDL of a reservoir 显示文摘 | Chen C W Laura Weintraub L H Z Herr J | 2000 | Environment Science & Policy2000，，3： | 1 |
| 17 | Synthesis and preliminary evaluation of selected 2-aryl-5 (6)-nitro-lH- henzimidazole derivatives as potential anticancer agents显示文摘 | Aurelio R C Ismael L R Laura Citlalli A R | 2011 | Arch Pharm Res2011，34，2： | 1 |
| 18 | Aromatic Characterization of Pot Distilled Kiwi Spirits 显示文摘 | Cristina L V Laura G L Ricardo P C | 2012 | J Agric Food Chem2012，60，9： | 1 |
| 19 | A Dyadic Study of Interpersonal Information Search 显示文摘 | Gilly Mary C John L Graham Mary Finley Wolfinbarger Laura J Yale | 1998 | Journal of Academy of Marketing Science1998，26，2： | 1 |
| 20 | Glycosylation of individual whey proteins by maillard reaction using dextran of different molecular mass显示文摘 | LAURA J N C VILLAMIEL M ROSINA L P F | 2007 | Food Hydrocolloids2007，21，： | 1 |
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