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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | The progression from hypertension to congestive heart failure 显示文摘 | Levy D Larson M G Vasan R S | 1996 | JAMA1996，275，20： | 1 |
| 3 | Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study; evidence for susceptibility loci on 1q显示文摘 | Dupuis J Larson M G Vasan R S | 2005 | Atherosclerosis2005，182，2： | 1 |
| 4 | A practical approach to guide clinicians in the evaluation of male patients with breast masses 显示文摘 | Hines S L Tan W Larson J M | 2008 | Geriatrics2008，63，6： | 1 |
| 5 | Contrasting mode of evolution at a coat color locus in wild and domestic pigs显示文摘 | FANG M LARSON G RIBEIRO H S | 2009 | PloS Genetics2009，5，10： | 1 |
| 6 | Long-term trends in the incidence of and survival with heart failure显示文摘 | LEVY D KENCHAIAH S LARSON M G | 2002 | N Engl J Med2002，347，18： | 1 |
| 7 | Does the relation of blood pressure to coronary heart disease risk change with aging The Framingham heart study显示文摘 | Franklin S S Larson M G Khan S A | 2001 | Circulation2001，103，： | 1 |
| 8 | Effect of surfactant layers on the size changes of aerosol particles as a function of relative humidity显示文摘 | ANDREWS E LARSON S M | 1993 | Envi- ronmental Science & Technology1993，27，5： | 1 |
| 9 | Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to longdistance transfers显示文摘 | Larson D M Duval S Sharkey S W | 2012 | Eur Heart J2012，33，10： | 1 |
| 10 | Obesity and systemic oxidative stress:clinical correlates of oxidative stress in the Fram- ingham Study显示文摘 | Keaney J F Jr Larson M G Vasan R S | 2003 | Aeterioscler Thromb Vasc Biol2003，23，3： | 1 |
| 11 | Reproductive biology on island and mainland population of Primula mistassinica on Lake Huron shorelines 显示文摘 | Larson B M H Barrett S C H | 1998 | Can J Bot1998，76，11： | 1 |
| 12 | Scaling in the Safety of Next Generation Reactors 显示文摘 | Banerjee S Ortiz M Q Larson T K | 1998 | Nuclear Engineering and Design1998，186，： | 1 |
| 13 | Learning crowdsourced user preferences for visual summarization of image collections显示文摘 | Rudinac S Larson M and Hanjalic A | 2013 | IEEE Transactions on Multimedia2013，15，6： | 1 |
| 14 | Impaired heart rate response to graded exercise:Prognostic implications of Chronotropic incompetence in the Framingham heart study显示文摘 | LAUER M S OKIN P M LARSON M G | 1996 | Circulation1996，93，8： | 1 |
| 15 | Longterm outcomes in indi- viduals with prolonged PR interval or first-degree atrioventricular block显示文摘 | Cheng S Keyes M J Larson MG | 2009 | JAMA2009，301，： | 1 |
| 16 | Impact of high - normal blood pressure on the risk of cardiovascular disease 显示文摘 | Vasari R S Larson M G Leip E P | 2001 | N Engl J Med2001，345，18： | 1 |
| 17 | Deratofibrosarcoma protuberans:a report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature显示文摘 | Snow S N Gordon E M Larson P O | 2004 | Cancer2004，101，1： | 1 |
| 18 | Repurposing CRISPR as an RNA-guided platform for seguence- specific control of gene expression显示文摘 | Qi L S Larson M H Gilbert L A | 2013 | Cell2013，152，5： | 1 |
| 19 | Impact of high normal blood pressure on the risk of cardiovascular disease显示文摘 | Vasan R S Larson M G Leip E P | 2001 | N Engl J Med2001，345，18： | 1 |
| 20 | Is gratitude a moral affect 显示文摘 | McCullough M E Kilpatrick S D Emmons R A larson D B | 2001 | Psychological Bulletin2001，127，24： | 1 |
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