|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Composition, source, mass closure of PM_(2.5) aerosols for four forests in eastern China显示文摘PM2.5 aerosols were collected in forests along north latitude in boreal-temperate, temperate, subtropical and tropical climatic zones in eastern China, i.e., Changbai Mountain Nature Reserve (CB), Dongping National Forest Park in Chongming Island (CM), Dinghu Mountain Nature Reserve (DH), Jianfengling Nature Reserve in Hainan Island (HN). The mass concentrations of PM2.5, organic carbon (OC), elemental carbon (EC), water soluble organic carbon (WSOC) as well as concentrations of ten inorganic ions (F-, Cl-, NO3-, SO42-, C2O42-, NH4+, Na+, K+, Ca2+, Mg2+) were determined. Aerosol chemical mass closures were achieved. The 24-hr average concentrations of PM2.5 were 38.8, 89.2, 30.4, 18 μg/m3 at CB, CM, DH and HN, respectively. Organic matter and EC accounted for 21%-33% and 1.3%-2.3% of PM2.5 mass, respectively. The sum of three dominant secondary ions (SO42-, NO3-, NH4+) accounted for 44%, 50%, 45% and 16% of local PM2.5 mass at CB, CM, DH and HN, respectively. WSOC comprised 35%-65% of OC. The sources of PM2.5 include especially important regional anthropogenic pollutions at Chinese forest areas. | Li Li Wu Wang Jialiang Feng Dongping Zhang Huaijian Li Zeping Gu Bangjin Wang Guoying Sheng Jiamo Fu | 2010 | Journal of Environmental Sciences2010，22，3： | 45 |
| 3 | Model of water-sediment regulation in Yellow River and its effect显示文摘Water-sediment regulation of the Yellow River is to regulate and control the flow and sediment transport relationship of the lower reaches through reservoirs on the main streams and tributaries to create balance between water and sediment so that sediment transport capacity of the downstream channels can be maximized,shrinking of channels be contained,and medium flood channel be restored and maintained.Many years' research by the Yellow River Conservancy Commission(YRCC) reveals the water and sediment transport relationship that will prevent sedimentation at the downstream river channels.Based on this relationship and coming sediment and water conditions in the Yellow River basin,the YRCC,with maximized use of reservoirs on the main streams and tributaries,has developed three models of water-sediment regulation:single Xiaolangdi Reservoir-dominated regulation,space scale water-sediment match,and mainstream reservoirs joint operation.Ten water-sediment regulations based on these three models have resulted in an average drop of 1.5 m in the main channel of the downstream 800 km river and an increase of carrying capacity from 1800 to 4000 m3/s.Besides,the wetland ecosystems of estuarine delta has also been improved and restored significantly. | LI GuoYing SHENG LianXi | 2011 | Science China(Technological Sciences)2011，54，4： | 18 |
| 4 | Fiducial inference in the pivotal family of distributions显示文摘In this paper a family, called the pivotal family, of distributions is considered.A pivotal family is determined by a generalized pivotal model. Analytical results show that a great many parametric families of distributions are pivotal. In a pivotal family of distributions a general method of deriving fiducial distributions of parameters is proposed. In the method a fiducial model plays an important role. A fiducial model is a function of a random variable with a known distribution, called the pivotal random element, when the observation of a statistic is given.The method of this paper includes some other methods of deriving fiducial distributions. Specially the first fiducial distribution given by Fisher can be derived by the method. For the monotone likelihood ratio family of distributions, which is a pivotal family, the fiducial distributions have a frequentist property in the Neyman-Pearson view. Fiducial distributions of regular parametric functions also have the above frequentist property. Some advantages of the fiducial inference are exhibited in four applications of the fiducial distribution. Many examples are given, in which the fiducial distributions cannot be derived by the existing methods. | XU Xingzhong & LI Guoying Department of Mathematics, Beijing Institute of Technology, Beijing 100081, China Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100080, China | 2006 | Science China Mathematics2006，49，3： | 16 |
| 5 | QTG-Seq Accelerates QTL Fine Mapping through QTL Partitioning and Whole-Genome Sequencing of Bulked Segregant Samples显示文摘Deciphering the genetic mechanisms underlying agronomic traits is of great importance for crop improvement. Most of these traits are controlled by multiple quantitative trait loci (QTLs), and identifying the underlying genes by conventional QTL fine-mapping is time-consuming and labor-intensive. Here, we devised a new method, named quantitative trait gene sequencing (QTG-seq), to accelerate QTL fine-mapping. QTGseq combines QTL partitioning to convert a quantitative trait into a near-qualitative trait, sequencing of bulked segregant pools from a large segregating population, and the use of a robust new algorithm for identifying candidate genes. Using QTG-seq, we fine-mapped a plant-height QTL in maize (Zea mays L.), qPH7, to a 300-kb genomic interval and verified that a gene encoding an NF-YC transcription factor was the functional gene. Functional analysis suggested that qPH7-encoding protein might influence plant height by interacting with a CO-like protein and an AP2 domain-containing protein. Selection footprint ana卜 ysis indicated that qPH7 was subject to strong selection during maize improvement. In summary, QTG-seq provides an efficient method for QTL fine-mapping in the era of “big data'. | Hongwei Zhang Xi Wang Qingchun Pan Pei Li Yunjun Liu Xiaoduo Lu Wanshun Zhong Minqi Li Linqian Han Juan Li Pingxi Wang Dongdong Li Yan Liu Qing Li Fang Yang Yuan-Ming Zhang Guoying Wang Lin Li | 2019 | Molecular Plant2019，12，3： | 13 |
| 6 | Diurnal variations of polycyclic aromatic hydrocarbons associated with PM_(2.5) in Shanghai, China显示文摘Forty-eight daily time interval PM2.5 samples were collected from December 2006 to January 2008 in an urban site in Shanghai, China. Concentrations and compositions of polycyclic aromatic hydrocarbons (PAHs) were analyzed with GC-MS to study the diurnal and seasonal variations and to identify the main emitting sources. The diurnal variation of the PAHs concentrations was greater in the late autumn and winter sampling days, and was greatly influenced by meteorological conditions such as wind speed and ambient temperature. The concentration of PAHs in the mornings (6:30-10:00) increased distinctly, and was high in the late autumn and winter sampling days, indicating the contribution from vehicle emissions during rush hours. The diurnal variation of the high molecular weight PAHs did not seem to be controlled by the shift of gas-particle partitioning due to temperature variation, instead, it could be indicative of the variation in the source. Statistical analyses showed that the concentrations of PAHs were negatively correlated with temperature and wind speed, and positively correlated with relative humidity. Diagnostic ratios of PAHs suggested mixed emission sources of petroleum and coal/biomass combustion for PAHs in the PM2.5 in Shanghai. | Zeping Gu Jialiang Feng Wenliang Han Li Li Minghong Wu Jiamo Fu Guoying Sheng | 2010 | Journal of Environmental Sciences2010，22，3： | 13 |
| 7 | Regulation of Seed Vigor by Manipulation of Raffinose Family Oligosaccharides in Maize and Arabidopsis thaliana显示文摘棉白糖家庭 oligosaccharides (RFO ) 在许多植物种类在成熟干燥期间在种子积累。然而, RFO 是否在建立种子活力有一个角色,仍然保持不清楚。GALACTINOL SYNTHASE (GOLS ) ,棉白糖 SYNTHASE (RS ) ,和 STACHYOSE SYNTHASE (圣) 是为 RFO 负责的酶 ? 在植物的生合成。有趣地,仅仅棉白糖在玉米种子被检测,并且唯一的玉米 RS 基因(ZmRS ) 被识别。在这研究,我们发现二独立 mutator (亩) 打断了 zmrs 线,不包含棉白糖但是 hyperaccumulating galactinol, ? 显著地减少了种子活力,与空 segregant 控制相比。不同于玉米, Arabidopsis thaliana 种子包含几 RFO (棉白糖, stachyose,和 verbascose ) 。A 的操作。thaliana RFO ? 由 overexpressing ZmGOLS2, ZmRS,或 AtSTS 的内容表明了那 co-overexpression ZmGOLS2 和 ZmRS,或 ZmGOLS2 的 overexpression 独自一个,显著地增加了 RFO 的全部的内容并且提高了 Arabidopsis 种子活力。令人惊讶地,当 ZmRS 的 overexpression 增加了种子棉白糖内容时,它的 overexpression 戏剧性地减少了种子活力并且减少了 galactinol, stachyose,和 verbascose 的种子数量。相反, atrs5 异种种子类似于关于种子活力和 RFO 内容的野类型的那些,除了 stachyose 它在 atrs5 种子积累了。全部的 RFO, RFO/sucrose 比率,然而并非绝对单个 RFO ? 数量,断然与 A 相关。thaliana 种子活力, stachyose 和 verbascose 多于棉白糖作出贡献到。一起拿,这些结果提供新卓见进种子活力的规章的机制并且在 monocot 和 dicot 在 modulating 种子活力为 RFO 揭示不同要求。 | Tao Li Yumin Zhang Dong Wang Ying Liu Lynnette M.A. Dirk Jack Goodman A. Bruce Downie Jianmin Wang Guoying Wang Tianyong Zhao | 2017 | Molecular Plant2017，10，12： | 13 |
| 8 | A new elliptic-parabolic yield surface model revised by an adaptive criterion for granular soils显示文摘An adaptive criterion for shear yielding as well as shear failure of soils is proposed in this paper to address the fact that most criteria,including the Mohr-Coulomb criterion,the Lade criterion and the Matsuoka-Nakai criterion,cannot agree well with the experimental results when the value of the intermediate principal stress parameter is too big.The new criterion can adjust an adaptive parameter based on the experimental results in order to make the theoretical calculations fit the test results more accurately.The original elliptic-parabolic yield surface model can capture both soil contraction and dilation behaviors.However,it normally over-predicts the soil strength due to its application of the Extended Mises criterion.A new elliptic-parabolic yield surface mode is presented in this paper,which introduces the adaptive criterion in three-dimensional principal stress space.The new model can well model the stress-strain behavior of soils under general stress conditions.Compared to the original model which can only simulate soil behavior under triaxial compression conditions,the new model can simulate soil behaviors under both triaxial compression conditions and general stress conditions. | LIU HanLong 1,2 ,XIAO Yang 1,2 ,LIU JinYuan 3 &LI GuoYing 4 1 Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering,Hohai University, Nanjing 210098,China 2 Geotechnical Research Institute,Hohai University,Nanjing 210098,China 3Department of Civil Engineering,Ryerson University,Toronto,Canada 4 Department of Geotechnical Engineering,Nanjing Hydraulic Research Institute,Nanjing 210014,China | 2010 | Science China(Technological Sciences)2010，53，8： | 12 |
| 9 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 10 | Geochemical characteristics and applications of 18α(H)-neohopanes and 17α(H)-diahopanes显示文摘Distributions and geochemical significances of 18α(H)-neohopanes and of 17α(H)-diahopanes in oils from west Xialiaohe depression of the Bohai Bay Basin have been studied. Relative abundance of 18α(H)-neohopanes and of 17α(H)-diahopanes can be effectively used as maturity parameters, in a range of medium-high mature stage, based on consideration on sedimentary-organic facies of source rocks. With a dual geochemical significance of maturity and sedimentary-organic facies, neohopane and diahopane parameters can be well used in oil-source correlation and in petroleum population division. Formation, primary concentration and preservation of precursors of rearranged hopanes are closely related to depositional conditions such as Eh-pH and clays content. A series of probable diahopanes (series D) was detected in the oils, which exhibits a similar distribution pattern and geochemical behavior as that of 17α(H)-diahopanes (series B). | WANG Chunjiang, FU Jiamo, SHENG Guoying, XIAO Qianhua, LI Jinyou, ZHANG Yali & PIAO Mingzhi1. Slate Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences. Guang/hou 510640, China 2. Department of Geosciences, Petroleum University, Beijing 102200, China 3. Institute of Petroleum Exploration and Exploitation, Liaohe Bureau of Petroleum Exploration, Panjin 240000, China | 2000 | Chinese Science Bulletin2000，45，19： | 9 |
| 11 | Effects of adding bulking agents on the biodrying of kitchen waste and the odor emissions produced显示文摘The effects of adding a bulking agent on the performance and odor emissions(ammonia and eight sulfur-containing odorous compounds) when biodrying kitchen waste were investigated. Three treatments were considered: the addition of either cornstalks(CS) or wood peat(WP) to kitchen waste as a bulking agent before biodrying, and a control treatment(CK). The water-removal rates for CK, CS, and WP treatments were 0.35, 0.56, and0.43 kg/kg, respectively. Addition of bulking agents to kitchen waste produced less leachate,higher moisture-removal rates, and lower consumption of volatile solids. The CS treatment had the highest biodrying index(4.07), and those for the WP and CK treatments were 3.67 and 1.97, respectively. Adding cornstalks or wood peat decreased NH3 emissions by 55.8%and 71.7%, respectively. Total sulfur losses were 3.6%–21.6% after 21 days biodrying, and H2 S and Me2 SS were the main(> 95%) sulfur compounds released. The smallest amounts of sulfur-containing odorous compounds were emitted when cornstalks were added, and adding cornstalks and wood peat decreased total sulfur losses by 50.6%–64.8%. | Jing Yuan Yun Li Hongyu Zhang Difang Zhang David Chadwick Guoxue Li Guoying Wang Menghao Chi Fan Yang | 2018 | Journal of Environmental Sciences2018，30，5： | 7 |
| 12 | Magnetic performance and corrosion resistance of electroless plating CoWP film显示文摘The CoWP film with good magnetic performance and corrosion resistance was electrolessly plated from alkaline solution. The technical parameters of the electroless plating system were optimized. When the pH value of electroless plating solution was 11.0 and the reducing agent (NaH2PO2) content was 0.4 mol L 1, the target chemical reactions proceeded in the electroless plating solution smoothly with negligible interference and side effects. CoWP film prepared under optimal deposition condition contained more hexagonal close-packed (hcp) cobalt (ε-Co) of [110] and crystallographic orientation of Co [002]. VSM analysis reveals that the saturation magnetization of the CoWP film is 100~220 Am2 kg 1 and coercivity is (2.87~4.38)×104 A·cm 1. The corrosion behavior of CoWP film in 3.5% NaCl aqueous solution was studied by electrochemical experiments. The results prove that the corrosion resistance of the CoWP film deposited under the optimal depo-sition condition exhibites relatively lower corrosion current of (3.054~3.162)×10 6 A·cm 2. The surface morphology analysis indicates that the film is smooth and composed of regular-shaped crystallites. | Jiang, Li Pan, Shanshan Lu, Jianbiao Ke, Xin He, Wenhao Yu, Yundan Wei, Guoying Ge, Hongliang | 2012 | Rare Metals2012，31，3： | 6 |
| 13 | The U6 Biogenesis-Like I Plays an Important Role in Maize Kernel and Seedling Development by Affecting the 3' End Processing of U6 snRNA显示文摘 | Jiankun Li Junjie Fu Yan Chen Kaijian Fan Cheng He Zhiqiang Zhang Li Li Yunjun Liu Jun Zheng Dongtao Ren Guoying Wang | 2017 | Molecular Plant2017，10，3： | 5 |
| 14 | C:N:P stoichiometry of Ericaceae species in shrubland biomes across Southern China:influences of climate,soil and species identity显示文摘Aims Carbon(C),nitrogen(N)and phosphorus(P)stoichiometry strongly affect functions and nutrient cycling within ecosystems.However,the related researches in shrubs were very limited.In this study,we aimed to inves-tigate leaf stoichiometry and its driving factors in shrubs,and whether stoichiometry significantly differs among closely related species.Methods We analyzed leaf C,N and P concentrations and their ratios in 32 species of Ericaceae from 161 sites across southern China.We examined the relationships of leaf stoichiometry with environmen-tal variables using linear regressions,and quantified the interactive and independent effects of climate,soil and species on foliar stoi-chiometry using general linear models(GLM).Important Findings The foliar C,N and P contents of Ericaceae were 484.66,14.44 and 1.06 mg g−1,respectively.Leaf C,N and P concentrations and their ratios in Ericaceae were significantly related with latitude and altitude,except the N:P insignificantly correlated with latitude.Climate(mean annual temperature and precipitation)and soil properties(soil C,N and P and bulk density)were significantly influenced element stoichiom-etry.The GLM analysis showed that soil exerted a greater direct effect on leaf stoichiometry than climate did,and climate affected leaf traits mainly via indirect ways.Further,soil properties had stronger influ-ences on leaf P than on leaf C and N.Among all independent factors examined,we found species accounted for the largest proportion of the variation in foliar stoichiometry.These results suggest that species can largely influence foliar stoichiometry,even at a lower taxonomic level. | Qiang Zhang Qing Liu Huajun Yin Chunzhang Zhao Lin Zhang Guoying Zhou Chunying Yin Zhijun Lu Gaoming Xiong Yuelin Li Jiaxiang Li Wenting Xu Zhiyao Tang Zongqiang Xie | 2019 | Journal of Plant Ecology2019，12，2： | 4 |
| 15 | Fiducial intervals of restricted parameters and their applications显示文摘In practice, the unknown parameters are often restricted. This paper provides a general method for constructing the fiducial intervals of the restricted parameters. Applying the general method, the fiducial intervals are constructed for the location (scale)parameters and the difference (ratio) of two locations (scales) in a location (scale) family of distributions. The frequency properties of these intervals are verified. For a variance components model, the fiducial intervals for the three parameters of common interest are obtained. Their frequency properties are investigated theoretically and computationally. | LI Xinmin, LI Guoying & XU Xingzhong College of Mathematics and Information Sciences, Shandong University of Technology, Zibo 255049, China Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100800, China Department of Mathematics, Beijing Institute of Technology, Beijing 100801, China | 2005 | Science China Mathematics2005，48，11： | 4 |
| 16 | Testing for the maximum cell probabilities in multinomial distributions显示文摘This paper investigates one-sided hypotheses testing for p[1], the largest cell probability of multinomial distribution. A small sample test of Ethier (1982) is extended to the general cases. Based on an estimator of p[1], a kind of large sample tests is proposed. The asymptotic power of the above tests under local alternatives is derived. An example is presented at the end of this paper. | XIONG Shifeng LI Guoying | 2005 | Science China Mathematics2005，48，7： | 3 |
| 17 | A rate-dependent Prandtl-lshlinskii model for piezoelectric actuators using the dynamic envelope function based play operator显示文摘 | Meiju YANG Chunxia LI Guoying GU Limin ZHU | 2015 | Frontiers of Mechanical Engineering2015，10，1： | 3 |
| 18 | QTL analysis across multiple environments reveals promising chromosome regions associated with yield-related traits in maize under drought conditions显示文摘Drought is one of the most critical abiotic stresses influencing maize yield. Improving maize cultivars with drought tolerance using marker-assisted selection requires a better understanding of its genetic basis. In this study, a doubled haploid(DH) population consisting of 217 lines was created by crossing the inbred lines Han 21(drought-tolerant) and Ye 478(drought-sensitive). The population was genotyped with a 6 K SNP assay and 756 SNP(single nucleotide polymorphism) markers were used to construct a linkage map with a length of 1344 c M. Grain yield(GY), ear setting percentage(ESP), and anthesis–silking interval(ASI) were recorded in seven environments under well-watered(WW) and water-stressed(WS) regimes. High phenotypic variation was observed for all traits under both water regimes. Using the LSMEAN(least-squares mean) values from all environments for each trait, 18 QTL were detected, with 9 associated with the WW and 9 with the WS regime. Four chromosome regions,Chr. 3: 219.8–223.7 Mb, Chr. 5: 191.5–194.7 Mb, Chr. 7: 132.2–135.6 Mb, and Chr. 10: 88.2–89.4 Mb, harbored at least 2 QTL in each region, and QTL co-located in a region inherited favorable alleles from the same parent. A set of 64 drought-tolerant BC_3F_6 lines showed preferential accumulation of the favorable alleles in these four regions, supporting an association between the four regions and maize drought tolerance. QTL-by-environment interaction analysis revealed 28 ed QTL(environment-dependent QTL) associated with the WS regime and 22 associated with the WW regime for GY, ESP, and ASI. All WS QTL and55.6% of WW QTL were located in the ed QTL regions. The hotspot genomic regions identified in this work will support further fine mapping and marker-assisted breeding of drought-tolerant maize. | Xinmin Hu Guihua Wang Xuemei Du Hongwei Zhang Zhenxiang Xu Jie Wang Guo Chen Bo Wang Xuhui Li Xunji Chen Junjie Fu Jun Zheng Jianhua Wang Riliang Gu Guoying Wang | 2021 | The Crop Journal2021，9，4： | 3 |
| 19 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 3 |
| 20 | Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons显示文摘Heavy ion beams with high linear energy transfer exhibit more beneficial physical and biological performance than conventional X-rays, thus improving the potential of this type of radiotherapy in the treatment of cancer. However, these two radiotherapy modalities both cause inevitable brain injury. The objective of this study was to evaluate the effects of heavy ion and X-ray irradiation on the cytoskeleton and cytomechanical properties of rat cortical neurons, as well as to determine the potential mechanism of neuronal injury after irradiation. Cortical neurons from 30 new-born mice were irradiated with heavy ion beams at a single dose of 2 Gy and X-rays at a single dose of 4 Gy; subsequent evaluation of their effects were carried out at 24 hours after irradiation. An immunofluorescence assay showed that after irradiation with both the heavy ion beam and X-rays, the number of primary neurons was significantly decreased, and there was evidence of apoptosis. Radiation-induced neuronal injury was more apparent after X-irradiation. Under atomic force microscopy, the neuronal membrane appeared rough and neuronal rigidity had increased. These cell changes were more apparent following exposure to X-rays. Our findings indicated that damage caused by heavy ion and X-ray irradiation resulted in the structural distortion and rearrangement of the cytoskeleton, and affected the cytomechanical properties of the cortical neurons. Moreover, this radiation injury to normal neurons was much severer after irradiation with X-rays than after heavy ion beam irradiation. | Yuting Du Jie Zhang Qian Zheng Mingxin Li Yang Liu Baoping Zhang Bin Liu Hong Zhang Guoying Miao | 2014 | Neural Regeneration Research2014，9，11： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员