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| 1 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 2 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 3 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 4 | Effects of climatic condition on the performance metabolism and health status of weaned piglets显示文摘 | Le D J Hetpin P | 1994 | Livest Prod Sci1994，38，： | 1 |
| 5 | Diffusion tensor imaging:concepts and applications 显示文摘 | Le Bihan D Mangin J F Poupon C | 2001 | J Magn Reson Imaging2001，13，4： | 1 |
| 6 | Humoral immune response of flounder to Eduardsiella itarda : the pres- ence of various sizes of immunoglobulins in flounder 显示文摘 | Bang J D Kim J W Le S D | 1996 | Dis Aquat Org1996，26，3： | 1 |
| 7 | Potential impacts of clean air regulations on system operations显示文摘 | Le K D Golden J L Stansberry C J | 1995 | IEEE Transactions on Power Systems1995，，： | 1 |
| 8 | Altered Ca2 + handling in ventricular myocytes isolated from diabetic rats显示文摘 | Lagadic- Gossmann D Buckler K J Le Prigent K | 1996 | Am J Physiol1996，270，5： | 1 |
| 9 | MR diffusion tensor spectroscopy and imaging显示文摘 | P Basser J Mattiello D Le Bihan | 1994 | Biophysical Journal1994，66，： | 1 |
| 10 | Echo-planar imaging of intravoxel incoherent motion显示文摘 | Turner R Le Bihan D Maier J | 1990 | Radiology1990，177，2： | 1 |
| 11 | Numerical investigation of the performance of several static mixers显示文摘 | Rauline D Tanguy P A Le Blévec J M | 1998 | The Canadian Journal of Chemical Engineering1998，76，3： | 1 |
| 12 | Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia显示文摘 | Le Bihan D Delannoy J Levin RL | 1989 | Radiology1989，171，3： | 1 |
| 13 | Relative influence of the topography and chemistry of TiAl6V4 surfaces on osteoblastic cell behaviour 显示文摘 | Anselme K Linez P Bigerelle M Le Maguer D Le Maguer A Hardouin P Hildebrand H F Iost A Leroy J M | 2000 | Biomaterials2000，21，： | 1 |
| 14 | Postoperative irradiation of minor salivary gland malignancies of the head and neck显示文摘 | Le Q T Birdwell S Terris D J | 1999 | Radiother Oncol1999，52，2： | 1 |
| 15 | Influence of a high ambient temperature on stearoyl-CoA-desaturase in growing pigs显示文摘 | Kouba M Hermier D Le Dividich J | 1999 | Comparative Biochemistry and Physiology1999，124，： | 1 |
| 16 | Irrigated agriculture and wildllfe conservation: Conflict on a global scale显示文摘 | Le mly A D Kingsford R T Thompson J R | 2000 | Environ- ment Management2000，25，： | 1 |
| 17 | Intersubband resonant scattering in GaAs-Ga1-x Al As heterojunctions 显示文摘 | LE ADLEY D R FLETCHER R NICHOLAS R J | 1992 | Physical Review1992，，12： | 1 |
| 18 | Lithium polyacrylate as a binder for tin-cobalt-carbon negative electrodes in lithium-ion batteries显示文摘 | Li J Le D B Ferguson P P | | 0，，08： | 1 |
| 19 | Reactive Oxygen Species and Human Spermatozoa: Physiology and Pathology 显示文摘 | GRIVEAU J F LE LANNOU D | 1997 | Int J Androl1997，20，2： | 1 |
| 20 | KRAS mutations as an independent prognostic factor in pa- tients with advanced colorectal cancer treated with cetuximab 显示文摘 | Lievre A Bachet J B Boige V Cayre A Le Corre D Buc E | 2008 | J Clin Oncol2008，26，： | 1 |
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