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| 1 | Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention显示文摘Many epidemiological and experimental studies have suggested that dietary fiber plays an important role in colon cancer prevention. These findings may relate to the ability of fiber to reduce the contact time of carcinogens within the intestinal lumen and to promote healthy gut microbiota, which modifies the host's metabolism in various ways. Elucidation of the mechanisms by which dietary fiber-dependent changes in gut microbiota enhance bile acid deconjugation, produce short chain fatty acids, and modulate inflammatory bioactive substances can lead to a better understanding of the beneficial role of dietary fiber. This article reviews the current knowledge concerning the mechanisms via which dietary fiber protects against colon cancer. | Huawei Zeng Darina L Lazarova Michael Bordonaro | 2014 | World Journal of Gastrointestinal Oncology2014，6，2： | 19 |
| 2 | CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer显示文摘This paper reviews the distinctive roles played by the transcriptional coactivators CREB-binding protein(CBP) and p300 in Wnt/β-catenin signaling and cell physiology in colorectal cancer(CRC). Specifically, we focus on the effects of CBP- and p300-mediated Wnt activity on(1) neoplastic progression;(2) the activities of butyrate, a breakdown product of dietary fiber, on cell signaling and colonic cell physiology;(3) the development of resistance to histone deacetylase inhibitors(HDACis), including butyrate and synthetic HDACis, in colonic cells; and(4) the physiology and number of cancer stem cells. Mutations of the Wnt/β-catenin signaling pathway initiate the majority of CRC cases, and we have shown that hyperactivation of this pathway by butyrate and other HDACis promotes CRC cell apoptosis. This activity by butyrate may in part explain the preventive action of fiber against CRC. However, individuals with a high-fiber diet may still develop neoplasia; therefore, resistance to the chemopreventive action of butyrate likely contributes to CRC. CBP or p300 may modify the ability of butyrate to influence colonic cell physiology since the two transcriptional coactivators affect Wnt signaling, and likely, its hyperactivation by butyrate. Also, CBP and p300 likely affect colonic tumorigenesis, as well as stem cell pluripotency. Improvement of CRC prevention and therapy requires a better understanding of the alterations in Wnt signaling and gene expression that underlie neoplastic progression, stem cell fate, and the development of resistance to butyrate and clinically relevant HDACis. Detailed knowledge of how CBP- and p300 modulate colonic cell physiology may lead to new approaches for anti-CRC prevention and therapeutics, particularly with respect to combinatorial therapy of CBP/p300 inhibitors with HDACis. | Michael Bordonaro Darina L Lazarova | 2015 | World Journal of Gastroenterology2015，21，27： | 6 |
| 3 | Advances in biofilm aerobic reactors ensuring effective biofilm activity control 显示文摘 | Lazarova V Manem J | 1994 | Water Sci Tech1994，29，1011： | 2 |
| 4 | Dimensions of the triangle of Koch显示文摘 | Zhivadinovik J Lazarova D Gjorgov N | 2006 | Bratisl Lek Listy2006，107，4： | 1 |
| 5 | Treatment of phenolcontaining aqueous solutions by membrane-based solvent extraction in coupled ultrafiltration modules 显示文摘 | Lazarova Z Boyadzhieva S | 2004 | Chemical Engineering Journal2004，100，12： | 1 |
| 6 | Advances in biofilm aerobic reactors ensuring effective biofilm activity control 显示文摘 | Lazarova V Manem J | 1994 | Water Sci Technol1994，29，1011： | 1 |
| 7 | Reversed micelle solvents as tools of enzyme purification and enzyme-catalyzed conversion显示文摘 | Tonova Konstantza Lazarova Zdravka | 2008 | Biotechnology Advances2008，26，6： | 1 |
| 8 | The synthesis, magnetic purification and evaluation of 99mTc-labeled microbubbles 显示文摘 | Lazarova N Causey PW Lemon JA | 2011 | Nucl Med Biol2011，38，8： | 1 |
| 9 | A Novel Circulating Bed Reactor: Hydrodynamics, Mass Transfer and Nitrification Capacity显示文摘 | JULIEN Meyniel LAURENT Dural | 1997 | Chem Eng Sci1997，52，2122： | 1 |
| 10 | Application of large-scale hollow fiber membrane eontactors for simultaneous extractive removal and stripping of penicillin G 显示文摘 | Lazarova Z Syska B | 2002 | J Membr Sci2002，202，： | 1 |
| 11 | Pharmacological and genetic modulation of Wnt targeted Cre-Lox-mediated gene expression in colorectal cancer cells 显示文摘 | Bordonaro M Lazarova D L Sartorelli A C | 2004 | Nucleic Acids Res2004，32，8： | 1 |
| 12 | The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors显示文摘 | Michael Bordonaro Darina L. Lazarova Alan C. Sartorelli | 2007 | Experimental Cell Research2007，，8： | 1 |
| 13 | Wastewater disinfection by ozone: main parameters for process design显示文摘 | Pei Xu Marie-Laure Janex Philippe Savoye Arnaud Cockx Valentina Lazarova | 2002 | Water Research2002，，4： | 1 |
| 14 | Biofilm Characterization and Activity Analysis in Water and Wastewater Treatment显示文摘 | Lazarova V Manem J | 1995 | Wat Res1995，29，10： | 1 |
| 15 | Influence of enzyme aqueous souree on RME-based purification of α-amylase 显示文摘 | Tonova Konstantza Lazarova Zdravka | 2005 | Separation and Purification Technology2005，47，12： | 1 |
| 16 | The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors显示文摘 | Bordonaro M Lazarova DL Sartorelli AC | | 0，，08： | 1 |
| 17 | Advanced Wastewater Disinfection Technologies: State of the Art and Perspectives 显示文摘 | Lazarova V Savoye P Janex M L | 1999 | Water Science and Technology1999，40，45： | 1 |
| 18 | On the synthesis and photostability of some new naphthalimide dyes显示文摘 | Lazarova R Venkova Al | 2004 | Polymer Degradation and Stability2004，84，： | 1 |
| 19 | On the photostability of some naphthalimide dyes and their copolymers with methyl methacrylate显示文摘 | Lazarova R Bojinov V | 2003 | Polymer Degradation and Stability2003，82，1： | 1 |
| 20 | IgG anti?laminin -332 autoantibodies are present in a subset of patients with mucous membrane, but not bullous, pemphigoid 显示文摘 | Lazarova Z Salato VK Lanschuetzer CM et aI | 2008 | J Am Acad Dennatol2008，58，6： | 1 |
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