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| 1 | Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA显示文摘除了明确的脱氧核糖核酸修理小径,所有生活有机体发展了机制避免复制叉倒塌在复制由于脱氧核糖核酸的造成分裂的共有原子价修正被堵住的一个地点引起的细胞死亡。术语脱氧核糖核酸损坏忍耐(DDT ) 泛泛地被采用了包括房间由熬过堵住复制的损害与或没有联系 genomic 不稳定性的许多机制。最近的基因分析在优核质显示那 DDT,从酵母到人,与是无差错的和另外一个由二条平行小径组成高度诱变。在开始发育的酵母,有趣地,这二条小径被增殖的房间的顺序的修正调停由二 ubiquitination 建筑群 Rad6-Rad18 和 Mms2-Ubc13-Rad5 的原子抗原(PCNA ) 。由 Rad6-Rad18 的 PCNA 的导致损坏的 monoubiquitination 与增加的傻瓜发育不全支持 translesion 合成(TLS ) ,当在由 Mms2-Ubc13-Rad5 的一样的 K164 残余的 PCNA 的随后的 polyubiquitination 支持无差错的损害时绕过。从最近的研究获得的数据建议上述机制在更高的优核质被保存。特别地,哺乳动物包含多重专业化 TLS 聚合酶。在 TLS 聚合酶之一的缺点被连接了到 genomic 不稳定性和癌症。 | Parker L Andersen Fang Xu Wei Xiao | 2008 | Cell Research2008，18，1： | 6 |
| 2 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 5 | Appendectomy and Clostridium difficile colitis:Relationships revealed by clinical observations and immunology显示文摘Advances in understanding the interaction between the human immune system and the microbiome have led to an improved understanding of the function of the vermiform appendix as a safe-house for beneficial bacteria in the colon.These advances have been made despite long standing clinical observations that the appendectomy is a safe and effective procedure.However,more recent clinical data show that an appendectomy puts patients at increased risk for recurrent Clostridium difficile(C.difficile)-associated colitis,and probably other diseases associated with an altered microbiome.At the same time,appendectomy does not apparently put patients at risk for an initial onset of C.difficile-associated colitis.These clinical observations point toward the idea that the vermiform appendix might not effectively protect the microbiome in the face of broad spectrum antibiotics,the use of which precedes the initial onset of C.difficile-associated colitis.Further,these observations point to the idea that historically important threats to the microbiome such as infectious gastrointestinal pathogens have been supplanted by other threats,particularly the use of broad spectrum antibiotics. | Nathan L Sanders R Randal Bollinger Ryan Lee Steven Thomas William Parker | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 6 | Processing aid for poly(vinyl chloride)显示文摘 | Hising-yeh parker David L Dunkelberger | 1993 | J of Vinyl Technology1993，15，2： | 2 |
| 7 | Reflective Tomography Images from Range-resolved Laser Radar Measurements 显示文摘 | PARKER J K CRAIG E B KLICK D L el al | 1988 | Applied Optics1988，27，13： | 1 |
| 8 | From diathesis to dimorphism:the biology of gender differences in depression显示文摘 | PARKER G B BROTCHIE H L | 2004 | J Nerv Ment Dis2004，192，3： | 1 |
| 9 | Laser Warning Receiver Based on Coherence Discrimination显示文摘 | V A Manasson L S Sadovnik Jack H Parker | 1996 | Proceedings of IEEE1996，2，： | 1 |
| 10 | Clinical features of multiple glomustumors显示文摘 | Anakwenze 0 A Parker W L Schiefer T K | 2008 | Dermatol Surg2008，34，7： | 1 |
| 11 | Cytokine regulation by platelet activating factor in a human B cell line显示文摘 | Smith CS Parker L Shearer WT | 1994 | J Immunol1994，153，9： | 1 |
| 12 | Occam's inversion: a practical algorthm for generating smooth models from EM sounding data 显示文摘 | CONSTABLE S C PARKER R L CONSTABLE C G | 1987 | Geophysics1987，52，1： | 1 |
| 13 | Effect of metal cations on the viscosity of a pectin-like capsular polysaccharide from the cyanobacterium Microcystis flos-aquae C3-40显示文摘 | PARKER D L SCHRAM B R PLUDE J L | 1996 | Appl Envir Microbiol1996，62，： | 1 |
| 14 | Performance Appraisals: Usage, Criteria and Obserbations显示文摘 | Pettijohn L S Stephen Parker R Pettijohn C E Kent J L | 2001 | Journal of Management Development2001，20，9： | 1 |
| 15 | Efficient solution of the varia- tional equation for picec wise-linear differential equations 显示文摘 | PARKER T S CHUA L O | 1986 | Circuit Theory and Applications1986，14，： | 1 |
| 16 | Occam's inversion: A practical algorithm for generating smooth models from electromagnetic sounding data显示文摘 | Constable S C Parker R L Constable C G | 1987 | Geophysics1987，52，3： | 1 |
| 17 | Accuracy of MRI, MR arthrography, and ultrasound in the diagnosis of rotator cuff tears: a meta-analysis显示文摘 | de Jesus J O Parker L Frangos A J | 2009 | Am J Roeentgnol2009，192，6： | 1 |
| 18 | h's been a Pleasure Doing Busi- ness with You:A Strategic Analysis and Critique of University Change Management显示文摘 | Parker L | 2002 | Critical Perspectives on Accounting2002，13，56： | 1 |
| 19 | Parental Bonding Instrument(PBI)显示文摘 | Parker G Tupling H Brown L B | 1979 | British Journal of Medical Psychology1979，52，： | 1 |
| 20 | Effect of supplementing head-down displays with 3-Daudio during visual target acquisition显示文摘 | PARKER S P A SIMITH S E STEPHAN K L | 2004 | InternationalJournal of aviation psychology2004，14，3： | 1 |
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