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| 1 | 多囊卵巢综合征妇女血浆metastin水平与胰岛素抵抗及游离雄激素水平呈负相关显示文摘Objective:This study was designed to:1 measure,for the first time,metastin (kisspeptin) levels in women with polycystic ovary syndrome (PCOS),a condition associated with hypersecretion of LH and hyperandrogenemia; and 2 investigate the possible correlations between metastin and PCOS-related reproductive and metabolic disturbances. Design:Clinical study. Setting:University hospital. Patient(s):Twenty-eight obese and overweight (body mass index BMI > 25 kg/m2) women with PCOS,28 normal weight (BMI < 25 kg/m2) women with the syndrome,and 13 obese and overweight controls (ovulatory women without clinical or biochemical hyperandrogenemia)-were selected. Intervention(s):Blood samples were collected between day 3 and day 6 of a spontaneous bleeding episode in the PCOS groups and a menstrual cycle of the controls,at 9:00 AM,after an overnight fast. Main Outcome Measure(s):Circulating levels of LH,FSH,PRL,T,Δ4-androstenedione (A),DHEAS,17α-OH-P,sex hormone-binding globulin (SHBG),insulin,glucose,and metastin were measured. Result(s):Both normal weight women with PCOS and obese controls were less insulin resistant and had significantly higher metastin levels,compared to obese and overweight women with the syndrome. Plasma kisspeptin levels were negatively correlated with BMI,free androgen index,and indices of insulin resistance. Conclusion(s):These results indicate that metastin is negatively associated with free androgen levels. The PCOS-associated insulin resistance and consequent hyperinsulinemia probably contribute to this effect by 1 stimulating androgen synthesis by the polycystic ovary (PCO) and 2 suppressing SHBG production in the liver. | Panidis D. Rousso D. Koliakos G. A. Kourtis 李跃萍 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，12： | 2 |
| 2 | Analysis,monitoring and fault diagnosis of batch process using multi-block and multi-way PLS显示文摘 | Kourti T Lee J MacGregor J F | 1995 | J of Process Control1995，5，4： | 1 |
| 3 | Central precocious puberty due to hypothalamic hamartoma in a 7-month-old infant girl显示文摘 | IR HR Rousso Kourti Papandreou | 2008 | Eur J Pediatr2008，167，5： | 1 |
| 4 | Multivariate Dynamic Data Modeling for Analysis and Statistical Process Control of Batch Processes, Start-Ups and Grade Transitions 显示文摘 | Kourti T | 2003 | Journal of Chemometrics2003，17，1： | 1 |
| 5 | Parameter uncertainty in portfolio selection: Shrinking the inverse covariance matrix显示文摘 | Kourtis A Dotsis G Markellos R N | 2012 | Journal of Banking and Finance2012，36，25： | 1 |
| 6 | Comparing alternativeapproaches for multivariate statistical analysis of batch process data显示文摘 | Westerhuis J A Kourti T MacGregor J F | 1999 | Journal of Chemometrics1999，13，34： | 1 |
| 7 | Multivariate SPC methods for process and product monitoring显示文摘 | Kourti T MacGregor J F | 1996 | Journal of Quality Technology1996，28，4： | 1 |
| 8 | Hormone replacement therapy at the threshold of 21st century显示文摘 | Dimitrios Panidis David Rousso Anargyros Kourtis | 2001 | European Journal of Obstertics and Gynecology and Reproduction Biology2001，99，2： | 1 |
| 9 | Multivariate dynamic data modeling for analysis and statistical process control of batch processes, start-ups and grade transitions显示文摘 | Kourti T | 2003 | Journal of Chemomtrics2003，17，： | 1 |
| 10 | Association of the T45G polymorphism in exon 2 of the adiponectin gene with polycystic ovary syndrome:role of △4-androstenedione显示文摘 | Dimitrios Panidis Anargyros Kourtis Asterios Kukuvitis | 2004 | Hum Reprod2004，19，8： | 1 |
| 11 | Serum adiponectin levels in women with polycystic ovary syndrome 显示文摘 | Panidis D Kourtis A Farmakiotis D | 2003 | Hum Reprod2003，18，： | 1 |
| 12 | Assessment of oxy-fuel power generation technologies显示文摘 | Hadjipaschalis I Kourtis G Poullikkas A | 2009 | Renewable and Sustainable Energy Reviews2009，13，9： | 1 |
| 13 | Evaluation of video quality based on objectively estimated metric 显示文摘 | Koumaras H Kourtis A Martakos D | 2005 | Journal of Communications and Networks(S1229-2370)2005，7，3： | 1 |
| 14 | Modelling cell residence time of mobile terminals in cellular radio systems 显示文摘 | KOURTIS S TAFAZOLLI R | 2002 | Electronics Letters2002，38，1： | 1 |
| 15 | Statistical process control of multivariate processes 显示文摘 | MacGregor J F Kourti T | 1995 | Control Engineering Practice1995，3，3： | 1 |
| 16 | 显示文摘 | Ye P Kirschner DE Kourtis AP | 2004 | Curr HIV Res2004，2，2： | 1 |
| 17 | Adenomyosis 显示文摘 | Matalliotakis IM Kourtis AI Panidis DK | 2003 | Ob- stet Gynecol Clin North Am2003，30，1： | 1 |
| 18 | Successful surgical treatment ofprimary hyperparathyroidism during the thirdtrimester of pregnancy 显示文摘 | Petousis S Kourtis A Anastasilakis CD | 2012 | JMusculoskelet Neuronal Interact2012，12，1： | 1 |
| 19 | Process analysis monitoring and diagnosis using multivariate projection methods显示文摘 | Kourti T MacGregor J F | 1995 | Chemometrics and Intelligent Laboratory Systems1995，28，1： | 1 |
| 20 | Multivariate SPC methods for process and product monitoring显示文摘 | KOURTI T MACGREGOR J F | 1996 | Journal of Quality Technology1996，28，4： | 1 |
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