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| 1 | 核因子-κB是癌症治疗的好靶点吗?希望和缺陷显示文摘核因子κB(NF-κB)转录因子在许多生理过程中,如固有及获得性免疫应答、细胞增殖、细胞死亡和炎症,都起重要作用。目前已很清楚,NF-κB和控制其活性的信号通路的调节异常与癌症的发生发展以及患者对化疗和放疗产生耐受性有关。本文综述了NF-κB与癌症的关系、以NF-κB为靶点的癌症治疗潜能和益处以及这种治疗可能引发的并发症和缺陷。 | 姜娜 辛文妤 陆丽娜 Baud V Karin M | 2009 | 国际药学研究杂志2009，36，4： | 9 |
| 2 | 参与式管理解决冲突:遥感和GIS用作瑞典北部驯鹿业土地利用需求信息交流的工具显示文摘在解决复杂的土地管理问题时,对短缺或者有争执的资源进行地理评估有助于不同利益相关者之间沟通认识和增进理解。本文中,我们说明如何使用遥感和GIS收集和汇总瑞典北部驯鹿放牧者和其他土地使用者(林业、采矿业、旅游业等等)的土地使用活动及使用模式的信息。该项目主要基于最终的土地使用者,即驯鹿放牧者们所做的工作,体现了面向土地使用者的新的努力。发展驯鹿业的土地利用规划的基础有以下几个方面:收集并数字化传统的驯鹿栖息地生态学和景观信息;将这些信息与来自野外调查及基于人造卫星观测的植被分类结果整合;绘制其他土地使用者的活动情况图。最终的土地利用规划提供的信息有利于驯鹿放牧者与其他利益相关者之间的磋商,并有助于驯鹿管理实施。该项目可作为一种大众参与和计划编制的模式,从而使本土信息和先进的遥感技术融入一个交互式的过程中。 | Per Sandstrm Tina Granqvist Pahlén Lars Edenius Hans Tφmmervik Olle Hagner Leif Hemberg Hkan Olsson Karin Baer Thomas Stenlund Lars Gran Brandt Mikael Egberth 周立志 程利群 | 2003 | AMBIO-人类环境杂志2003，32，8： | 4 |
| 3 | Emergence of novel strains of avian infectious bronchitis virus in Sweden显示文摘 | Shahid Hussain Abro Lena H.M. Renstr?m Karin Ullman Mats Isaksson Siamak Zohari Désirée S. Jansson Sándor Belák Claudia Baule | 2011 | Veterinary Microbiology (-)2011，，2： | 2 |
| 4 | Phosphorylation meets ubiquitination:the control of NF-κB activity显示文摘 | Karin M Ben-Neriah Y | | 0，，： | 2 |
| 5 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 6 | Prevalence of and risk factors for malaria,filariasis,and intestinal parasites as single infections or co-infections in different settlements of Gabon,Central Africa显示文摘Background:Malaria,filariasis,and intestinal parasitic infections(IPIs)are common and frequently overlap in developing countries.The prevalence and predictors of these infections were investigated in three different settlements(rural,semi-urban,and urban)of Gabon.Methods:During cross-sectional surveys performed from September 2013 to June 2014,451 individuals were interviewed.In addition,blood and stool samples were analysed for the presence of Plasmodium,filarial roundworm,intestinal protozoan,and helminth infections.Results:Intestinal parasitic infections(61.1%),including intestinal protozoa(56.7%)and soil-transmitted helminths(STHs)(22.2%),predominated,whereas Plasmodium falciparum(18.8%),Loa loa(4.7%),and Mansonella perstans(1.1%)were less prevalent.Filariasis and STHs were mainly found in rural settlements,whereas a higher plasmodial infection prevalence rate was observed in the periurban area.The most common IPI was blastocystosis(48.6%),followed by ascaridiasis(13.7%),trichuriasis(11.8%),amoebiasis(9.3%),giardiasis(4.8%),and strongyloidiasis(3.7%).Hookworm was detected in one adult from rural Dienga.Adults had a higher prevalence of Blastocystis hominis and STHs,whereas Giardia duodenalis was more frequently observed among children aged below 5 years(P<0.01).The polyparasitism rate was 41.5%,with 7.0%Plasmodium-IPIs and 1.8%Plasmodium-STH co-infections.The multivariate analysis showed that living in a suburban area,belonging to the age group of 5-15 years,having none or a secondary education,or having an open body water close to home were significant risk factors for malaria(P≤0.01).For STH infections,identified risk factors were drinking untreated water and living in a rural area(P≤0.04).No significant predictors were identified for IPIs and malaria-IPI co-infection.Conclusions:This study reports a high prevalence of IPIs and intestinal protozoa,but a low rate of malaria-IPI co-infections in the study sites.Improvements in the living conditions of the population such as adequate water supply and proper health education and sanitation should be integrated into control strategies for malaria,STHs,and IPIs. | Noe Patrick M’bondoukwe Eric Kendjo Denise Patricia Mawili-Mboumba Jeanne Vanessa Koumba Lengongo Christelle Offouga Mbouoronde Dieudonne Nkoghe Fousseyni Toure Marielle Karine Bouyou-AkotetAuthor details | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 7 | Phosphorylation meets ubiquitination:The control of NF-κB activity显示文摘 | Karin M Ben-Neriah Y | 2000 | Annu Rev Immunol2000，18，4： | 1 |
| 8 | Phosphorylation meets ubiquitination: The control of NF-κB activity显示文摘 | Karin M Ben-Neriah Y | 2000 | Annu Rev Immunol2000，18，： | 1 |
| 9 | NF-κB in cancer:from innocent bystander to major culprit显示文摘 | Karin M Cao Y Greten FR | 2002 | Nature Reviews2002，2，： | 1 |
| 10 | The IKK/NF-kB pathway显示文摘 | SENFTLEBEN U KARIN M | 2002 | Crit Care Med2002，30，1： | 1 |
| 11 | Chalcone 3-hydroxylation is not a general property of flavonoid 3 '-hydroxylase显示文摘 | KARIN S SILV/JA M FUAT T | 2009 | Plant Science2009，177，2： | 1 |
| 12 | Immunity,inflammation,and cancer显示文摘 | Grivennikov SI Greten FR Karin M | | 0，，06： | 1 |
| 13 | Immunity, inflammation and cancer显示文摘 | Gfivennikov S I Greten F R Karin M | 2010 | Ce112010，140，6： | 1 |
| 14 | Regulation and function of NF-kappaB transcription factors in the immune system 显示文摘 | Vallabhapurapu S Karin M | 2009 | Annu Rev Immunol2009，，27： | 1 |
| 15 | Obesity,inflammation,and liver cancer显示文摘 | Sun B Karin M | 2012 | J Hepatol2012，56，3： | 1 |
| 16 | NF-kappaB and cancer: mechanisms and targets 显示文摘 | Karin M | 2006 | Mol Carcinog2006，45，： | 1 |
| 17 | Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls显示文摘 | Baud V Karin M | 2009 | Nat Rev Drug Discov2009，8，1： | 1 |
| 18 | Mamnudian MAP kinase signaling cascades 显示文摘 | Chang L Karin M | 2001 | Nature2001，410，6824： | 1 |
| 19 | Mammalian MAP kinase signaling cascades 显示文摘 | Chang L Karin M | 2001 | Nature2001，410，6824： | 1 |
| 20 | Phosphorlation meets ubiquition: The control of NF-Kb activity 显示文摘 | Ben-Nerih Y | 2000 | Annu Rev Immunol2000，18，： | 1 |
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