维普期刊资源整合服务平台（V6.5）

224篇 您的检索式：作者名="KWOK B"

选中清除导出查看参考文献查看引证文献引用追踪共12页首页上一页第1页下一页末页 /12 跳转

	题名	作者	年代	出处	被引量
1	Chemical conjugation of a novel antibody interleukin 2 immunoconjugate against c erbB 2 product显示文摘Objective To develop a new chemical method to produce a monoclonal antibody (MoAb) 520C9/recombinant human interleukin 2 (rhIL 2) conjugate Methods MoAb 520C9 reactive with the protooncogene c erbB 2 product P185 was chemically conjugated with rhIL 2 by using a simple two step method First, the rhIL 2 was activated by Sulfosuccinimidyl 4 [N maleimidomethyl] cyclohexane 1 carboxylate, a heterobifunctional linker, and N succinimidyl s acetylthioacetate was introduced onto 520C9 Then SATA on the 520C9 was reacted with the maleimide group on the activated rhIL 2 to generate 520C9 rhIL 2 immunoconjugate Results The immunoconjugate retained the antigen binding activity compared to the respective native antibody as determined by an indirect live cell binding assay The immunoconjugate also possessed IL 2 activity as measured by the standard CTLL 2 cells proliferation assay and the stimulation of human peripheral blood mononuclear cells (PBMCs) into lymphokine activated killer cells Conclusion Our method of conjugation of rhIL 2 to 520C9 preserves the binding activity of the antibody and the cytokine function of IL 2 This simple and efficient method of conjugation should be applicable to other types of MoAbs and recombinant	李君 Sharon E Lee Marie Belciug David B Ring Cheuk S Kwok	2000	Chinese Medical Journal2000，，2：	3
2	Acquired segmental colonic hypoganglionosis in an adult Caucasian male:A case report显示文摘BACKGROUND Hypoganglionosis is a rare condition that most often presents with abnormal gastrointestinal transit and usually arises in early childhood or adolescence. Two types have been described(Type I and Type II). The adult-onset form(acquired hypoganglionosis) is extremely uncommon and is thought to arise due to cellular remodelling as a result of chronic inflammation. It differs from Hirschprung's disease in that there is a reduction in ganglion cells in the colonic neural plexuses as opposed to being completely absent.CASE SUMMARY A 31 year-old male presented to hospital with recurrent abdominal pain and vomiting over thirteen months. Abdominal computed tomography scans demonstrated thickening and stranding affecting the transverse, descending and sigmoid colon. Endoscopic appearances were non-specific but confirmed a mixed picture of mucosal inflammation and necrosis in various stages of healing.Numerous investigations were performed to elucidate an underlying aetiology but neither an infective nor ischaemic cause could be proven. Biopsy features were not typical of inflammatory bowel disease. Due to persistence of his symptoms and failure of medical management, a segmental colectomy was performed. Histological examination of the specimen revealed an unexpected finding of segmental hypoganglionosis. Complete surgical excision of the diseased segment of colon was curative and since his operation the patient has had no recurrence of symptoms requiring hospitalisation.CONCLUSION Our case serves to raise awareness of acquired hypoganglionosis as a rare condition that can result from chronic colitis.	Allan MF Kwok Andrew B Still Kimberly Hart	2019	World Journal of Gastrointestinal Surgery2019，11，2：	3
3	Control of wind-induced tall building vibration by tuned mass dampers显示文摘	Xu Y L Kwok K C S Samali B		0，，01：	2
4	Corallivory and preychoice by Drupella rugosa (Gastropoda: Muricidae) inHong Kong 显示文摘	Morton B Blackmore G Kwok C T	2002	Journal of Molluscan Studies2002，68，2：	1
5	Good,bad or optimal? Performance assessment of MIMO processes显示文摘	Huang B Shah S L Kwok E K	1997	Automatica1997，33，6：	1
6	Optimal dietary protein level of Penaeus monodon reared in seawater and brackishwater显示文摘	KWOK C C CHOU B S	1991	Nippon Suisan Gakkaishi1991，57，4：	1
7	Arabidopsis ethyleneresporise gene ETRI:similarity of product to two-component regulators显示文摘	Chang C Kwok S F Bleecker A B	1993	Science1993，162，：	1
8	Addressing climate change in comfort standards显示文摘	Kwok A G Rajkovich N B	2010	Building and Environment2010，45，1：	1
9	Allopurinol hypersensitivity syn- drome in patients with hematological malignancies: characteristics and clinical outcomes 显示文摘	Min H K Lee B Kwok S - K	2015	The Korean Journal of Internal Medicine2015，30，4：	1
10	Arabidopsis ethylene-response gene ETRI: similarity of product to two- component regulators显示文摘	Chang C Kwok S F Bleecker A B	1993	Science1993，262，：	1
11	Screening for anti-inflammatory and bronchorelaxant activities of 12commonly used Chinese herbal medicines 显示文摘	Yue G G Chan B C Kwok H F	2012	Phytother Res2012，26，6：	1
12	Use of viscoelastic dampers in reducing wind-incluced and earthquake-induced motion of building structures 显示文摘	Samali B Kwok K C S	1995	Engineering Structures1995，17，9：	1
13	Sentinel lymph node dissection in papil ary thyroid carcinoma显示文摘	Chow T L Lim B H Kwok S P		0，，1：	1
14	Fault detection and isolation in stochastic non-linear state-space models using particle filters显示文摘	F Alrowaie R B Gopaluni K E Kwok	2012	Control Engineering Practice2012，20，10：	1
15	Optimal dietary protein level of Penaeus monodon reared in seawater and brackish water显示文摘	Shiau S Y Kwok C C Chou B S	1991	Nip- pon Suisan Gakkaishi1991，57，：	1
16	FOXM1 confers acquired cisplatin resistance in breast cancer cells 显示文摘	Kwok JM Peck B Monteiro LJ	2010	Mol Cancer Res2010，8，1：	1
17	Resection of a benign brachial plexus nerve sheath tumor using intraoperative electrophysiological monitoring 显示文摘	Kwok K Davis B Kliot M	2007	Neurosurgery2007，60，42：	1
18	Identification of sea ice types in space borne synthetic aperture radar data显示文摘	Kwok R Rignot E Holt B	1992	J Geophys Res1992，97，2：	1
19	Performance assessment of multivariate control loops on a paper machine headbox显示文摘	HUANG B SHAH S L KWOK E etal	1997	Canadian Journal of Chemical Engineering1997，75，1：	1
20	Characteristics of multiple tuned liquid column dampers in suppressing structural vibration 显示文摘	Cao H Kwok K S C Samali B	1999	Engineering Structure1999，21，：	1

返回顶部每页显示：

共12页首页上一页第1页下一页末页 /12 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示