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| 1 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 2 | 无机硒和有机硒对羊瘤胃内容物的脂肪酸组成、瘤胃细菌和纤毛虫的影响显示文摘试验旨在研究3个月每天等摩尔饲喂有机硒和无机硒对瘤胃内容物脂肪酸组成、瘤胃细菌和原生动物的影响。12只羊饲喂含有干草1 380 g·只-1DM和大麦450 g·只-1DM的基础日粮,基础日粮中含硒0.16 mg·kg-1DM。将羊随机分成3组,包括饲喂基础日粮(对照组)、在基础日粮中添加无机硒0.4 mg·kg-1DM(Na2SeO3,ISe)、在基础日粮中添加有机硒0.4mg·kg-1DM(酵母硒,OSE)。测定瘤胃内容物(TRC)中脂肪酸(FA)含量、细菌数(BF)和纤毛原虫数(PF)。OSe组的TRC中C18:2cis-9,trans-11的含量显著降低(P<0.05),α-亚麻酸浓度(C18:3 N 3;LNA)极显著增加(P<0.01)。ISe组BF中肉豆蔻酸(C14:0;P<0.05)、棕榈酸(P<0.01)和中链脂肪酸(P<0.01)含量下降,长链脂肪酸(P<0.05)、硬脂酸(C18:0,P<0.01)、花生酸(C20:0,P<0.001)和山嵛酸(C22:0,P<0.01)含量升高。OSe组BF的辛酸(C8:0,P<0.001)、二十碳四烯酸(C20:4 n6,P<0.01)、二十碳三烯酸(C20:3 n3,P<0.01)浓度增加。ISe组PF的十二碳六烯酸(C22:6 n3)和tricosylic酸(C23:0,P<0.05)含量下降。添加OSe可以增加LNA的含量(P<0.01),降低棕榈油酸的含量(C16:1,P<0.05)。结果表明,饲粮中添加OSe可以通过瘤胃微生物影响多不饱和脂肪酸(PUFA)含量,特别是瘤胃纤毛虫,使多不饱和脂肪酸氢化成更饱和脂肪酸。 | Kiidayová S Mihaliková K Siroka P Cobanová K Váradyová Z | 2014 | 饲料博览2014，0，9： | 2 |
| 3 | Tau oligomers and aggregation in Alzheimer' s disease 显示文摘 | Meraz-Rios MA Lira-De Leon KI Campos-Pena V | 2010 | J Neurochem2010，112，6： | 1 |
| 4 | Role of neurotro- phic factors in depression 显示文摘 | Castren E Voikar V Rantam ki T | 2007 | Current Opinion in Pharmacology2007，7，1： | 1 |
| 5 | The measurement of business intelligence显示文摘 | L(o)nnqvistA Pirttim(a)ki V | | 0，，01： | 1 |
| 6 | Suggested terminology for duplex syslems, ectopicureters and ureteroceles显示文摘 | Glassberg KI Braren V Duckett JW | 1984 | J Urol1984，132，： | 1 |
| 7 | Neural stem cells-a versatile tool for cell replacement and gene therapy in the central nervous system显示文摘 | Ourednik J Park KI | 1999 | Clic Genet1999，56，： | 1 |
| 8 | Leptin, body composition and indices of malnutrition in patients on dialysis 显示文摘 | Johansen Ki Mulligan K Tai V | 1998 | J Am Sac Nephrol1998，9，6： | 1 |
| 9 | Distribution of insulin-like growth factor-Ⅰ mRNA in the mandibular condyle and rib cartilage of the rat during growth显示文摘 | Visnapuu V Peltom(a)ki T R(o)nning O | | 0，，11： | 1 |
| 10 | Reliability of the hip-to-ankle radiograph in determining the knee and implant alignment after total knee arthroplasty显示文摘 | Skytt?ET Haapam?ki V Koivikko M | | 0，，03： | 1 |
| 11 | Effects of the algicides CuSO4 and NaOCl on various physiological parameters in the harmful dinoflagellate Cochlodinium polykrikoides显示文摘 | Ebenezer V Lim W A Ki J S | 2014 | Journal of Applied Phycology2014，26，6： | 1 |
| 12 | Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid:comparison to bone marrow mesenchymal stem cells显示文摘 | Roubelakis MG Pappa KI Bitsika V | 2007 | Stem Cells Dev2007，16，6： | 1 |
| 13 | Neural stem cell-a versatiletool for cell replacement and gene therapy in the central nervous system显示文摘 | Ourednik V Ourednik J Park KI | 1999 | Cl in Genet1999，56，4： | 1 |
| 14 | Multiple or-gan dysfunction associated with severe acute pancreatitis显示文摘 | Halonen KI Pettila V Leppaniemi AK | 2002 | Crit Care Med2002，30，6： | 1 |
| 15 | Mutiple organdisfunction associated with severe aute pancreatitis显示文摘 | Halonen KI Pettila V Leppaniemi HC | 2002 | Crit Care Med2002，30，6： | 1 |
| 16 | On almost sure local and global central limit theorems显示文摘 | CS(A)KI E F(O)LDES A R(E)V(E)SZ P | 1993 | Probability Theory Related Fields1993，97，3： | 1 |
| 17 | Neural stem cells-a versatile tool for cell replacement and gene therapy in the central nervous system显示文摘 | Ourodnik V Ourednik J Park KI | 1999 | Clin Genet1999，56，： | 1 |
| 18 | Identical Hik-Rre systems are involved in perception and transduction of salt sig?nals and hyperosmotic signals but regulate the ex?pression of individual genes to different extents in Synechocystis显示文摘 | Shoumskaya M A Paithoonrangsarid K Kanesa?ki Y Los 0 A Zinchenko V V Tanticharoen M Suzuki I Murata N | 2005 | J Bioi Chem2005，280，21： | 1 |
| 19 | Multiple organ dysfunction associated with severe acute pancreatitis显示文摘 | Halonen KI Pettil(a) V Lepp(a0niemi AK | 2002 | Crit Care Med2002，30，6： | 1 |
| 20 | Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer 显示文摘 | BLUMENSCHEIN G R J R KIES M S PAPADIMITRA- KOPOULOU V A | 2008 | Invest New Drugs2008，26，1： | 1 |
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