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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Split liver transplantation in adults显示文摘Split liver transplantation(SLT),while widely accepted in pediatrics,remains underutilized in adults. Advancements in surgical techniques and donor-recipient matching,however,have allowed expansion of SLT from utilization of the right trisegment graft to now include use of the hemiliver graft as well. Despite less favorable outcomes in the early experience,better outcomes have been reported by experienced centers and have further validated the feasibility of SLT. Importantly,more than two decades of experience have identified key requirements for successful SLT in adults. When these requirements are met,SLT can achieve outcomes equivalent to those achieved with other types of liver transplantation for adults. However,substantial challenges,such as surgical techniques,logistics,and ethics,persist as ongoing barriers to further expansion of this highly complex procedure. This review outlines the current state of SLT in adults,focusing on donor and recipient selection based on physiology,surgical techniques,surgical outcomes,and ethical issues. | koji hashimoto masato fujiki cristiano quintini federico n aucejo teresa diago uso dympna m kelly bijan eghtesad john j fung charles m miller | 2016 | World Journal of Gastroenterology2016，22，33： | 3 |
| 3 | 乳汁免疫和猪流行性腹泻病毒病疫苗:历史和现状(译文)显示文摘由于肠道病毒感染导致仔猪在发病率、死亡率和生产能力丧失方面的影响,每年给养猪者带来数百万美元的损失。2013—2014年间,猪流行性腹泻病毒(PEDV)病的暴发给美国养猪业带来了9亿~18亿美元的经济损失。被动乳汁免疫被认为是保护新生哺乳仔猪免受PED等肠道疾病危害的最有希望和有效的方法。通过乳汁免疫被动保护哺乳仔猪的效果依赖于病原特异性IgA浆细胞转运至乳腺的数量和乳汁中分泌型IgA的积累程度,这种免疫途径被定义为'肠-乳腺-sIgA轴'。由于胎盘的不可穿透性,新生仔猪处于无免疫球蛋白的状态,对很多的传染性病原体极易感。它们仅依靠来源于母源的初乳和乳汁抗体获得被动保护。先前开发的关于猪传染性胃肠炎病毒(TGEV)病的活疫苗和灭活疫苗,提供了对母源性免疫和仔猪被动保护机制的理解。在这篇文章中,综述了猪传染性胃肠炎病毒诱导乳汁免疫的研究进展,并指出对当前养猪业正努力控制的猪流行性腹泻病毒感染和相关疫苗的研究方向。同时研究和鉴别出影响乳汁免疫和'肠-乳腺-sIgA轴'的各种因素,有助于改善妊娠母猪预防猪流行性腹泻病毒感染以及改进其它肠道病原用疫苗方案,从而达到提升整个猪群的免疫力、猪群健康和企业生产力的目的。 | Langel Stephanie N Paim Francine Chimelo Lager Kelly M Vlasova Anastasia N Saif Linda J 吕茂杰 | 2017 | 养猪2017，，1： | 3 |
| 4 | Endocrine regulation of menstruation 显示文摘 | Jabbour H N Kelly R W Fraser H M | 2006 | Endocr Rew2006，27，1： | 1 |
| 5 | Environmental and Intrapersonal Predictors of Reactions to Potential Territorial Intrusions in the Workplace 显示文摘 | WOLLMAN N KELLY B M BORDENS K S | 1994 | Environment and Behavior1994，26，2： | 1 |
| 6 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 7 | Dynamic contact mechan- ics of radial tears of the lateral meniscus:implications for treatment 显示文摘 | Bedi A Kelly N Baad M | 2012 | Arthroscopy2012，28，3： | 1 |
| 8 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 9 | Dispersion of cerussite-rich tailings and plant uptake of heavy metals at historical lead mines near Newtownards,Northern Ireland显示文摘 | Moles N R Smyth D Mather C E Beattie E H Kelly M | 2004 | Applied Earth Science2004，113，： | 1 |
| 10 | Endoscopic endonasal management of recurrent petrous apex cholesterolgranuloma显示文摘 | MCLAUGHLIN N KELLY D F PREVEDELLO D M | 2012 | J Neurol Surg B Skull Base2012，73，： | 1 |
| 11 | Theory and practice in assessing vul- nerability to climate change and facilitating adaptation 显示文摘 | Kelly P M Adger W N | 2000 | Climatic Change2000，47，： | 1 |
| 12 | Use of raltitrexed as an alterna- tive to 5-fluorouracil and capecitabine in cancer patients with cardi- ac history显示文摘 | Kelly C Bhuva N Harrison M | 2013 | EurJ Cancer2013，49，10： | 1 |
| 13 | Evapotranspiration covers: An innovative approach to remediate and close contaminated sites显示文摘 | KELLY L M DANIELLE N C RICHARD J W | 2003 | Remediation Winter2003，14，1： | 1 |
| 14 | Inorganic nitrogen in Australian semi-anthracites ; implications for determining organic nitrogen functionality in bituminous coals by X-ray photoelectron spectroscopy 显示文摘 | BUCKLEY A N KELLY M D NELSON P F | 1995 | Fuel Processing Technology1995，43，： | 1 |
| 15 | Deletion of UCP2 in iNOS deficient mice reduces the severity of the disease during experimental autoimmune encephalomyelitis 显示文摘 | Aheng C Ly N Kelly M | 2012 | PloS one2012，6，22： | 1 |
| 16 | A method for the use of landscape metrics in freshwater research and management显示文摘 | Kearns F R Kelly N M Carter J L | 2005 | Landscape Ecology2005，20，1： | 1 |
| 17 | A technique for the prediction of the conditions leading to mould growth in buildings显示文摘 | Clarke J A Johnstone C M Kelly N J et aI | 1999 | Building and En- vironment1999，34，4： | 1 |
| 18 | Use of rahitrexed as an al- ternative to 5-fluorouracil and capeeitabine in cancer patients with cardiac history显示文摘 | Kelly C Bhuva N Harrison M | 2013 | Eur J Cancer2013，49，10： | 1 |
| 19 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 20 | Social vulnerability to climate change and the architecture of entitlements显示文摘 | Adger W N Kelly P M | 1999 | Mitigation and adaptation strategies for global change1999，4，34： | 1 |
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