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| 1 | The effects of exercise on cognition in Parkinson’s disease: a systematic review显示文摘Cognitive impairments are highly prevalent in Parkinson’s disease(PD)and can substantially affect a patient’s quality of life.These impairments remain difficult to manage with current clinical therapies,but exercise has been identified as a possible treatment.The objective of this systematic review was to accumulate and analyze evidence for the effects of exercise on cognition in both animal models of PD and human disease.This systematic review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses(PRISMA)statement.Fourteen original reports were identified,including six pre-clinical animal studies and eight human clinical studies.These studies used various exercise interventions and evaluated many different outcome measures;therefore,only a qualitative synthesis was performed.The evidence from animal studies supports the role of exercise to improve cognition in humans through the promotion of neuronal proliferation,neuroprotection and neurogenesis.These findings warrant more research to determine what roles these neural mechanisms play in clinical populations.The reports on cognitive changes in clinical studies demonstrate that a range of exercise programs can improve cognition in humans.While each clinical study demonstrated improvements in a marker of cognition,there were limitations in each study,including non-randomized designs and risk of bias.The Grading of Recommendations Assessment,Development and Evaluation(GRADE)system was used and the quality of the evidence for human studies were rated from“low”to“moderate”and the strength of the recommendations were rated from“weak”to“strong”.Studies that assessed executive function,compared to general cognitive abilities,received a higher GRADE rating.Overall,this systematic review found that in animal models exercise results in behavioral and corresponding neurobiological changes in the basal ganglia related to cognition.The clinical studies showed that various types of exercise,including aerobic,resistance and dance can improve cognitive function,although the optimal type,amount,mechanisms,and duration of exercise are unclear.With growing support for exercise to improve not only motor symptoms,but also cognitive impairments in PD,health care providers and policy makers should recommend exercise as part of routine management and neurorehabilitation for this disorder. | Danielle K Murray Matthew A Sacheli Janice J Eng A Jon Stoessl | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 2 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 3 | Microstructural,Mechanical,Electrical,and Thermal Properties of the Bi-Sn-Ag Ternary Eutectic Alloy显示文摘The development of lead-free solders has emerged as one of the key issues in the electronics packaging industries.Bi-Sn-Ag eutectic alloy has been considered as one of the lead-free solder materials that can replace the toxic Pb-Sn eutectic solder without increasing soldering temperature.We investigated the effects of temperature gradient and growth rate on the mechanical,electrical and thermal properties of the BiSn-Ag ternary eutectic alloy.Bi-47 wt%Sn-0.68 wt%Ag alloy was directionally solidified upward with different temperature gradients(G=2.33-5.66 K/mm) at a constant growth rate(V=13.25 μm/s) and with different growth rates(V=6.55-132.83 μm/s) at a constant temperature gradient(G=2.33 K/mm) in the growth apparatus.The microstructures(λ),microhardness(HV),tensile stress(σ),electrical resistivity(ρ),and thermal properties(△H,C_p,T_m) were measured on directionally solidified samples.The dependency of the λ,HV,σ,and ρ on G and V was investigated.According to the experimental results,X values decrease with increasing G and V,but HV,λ,and ρ values increase with increasing G and V.Variations of electrical resistivity(ρ) for cast samples with the temperature in the range of 300-400 K were also measured by using a standard dc four-point probe technique.The enthalpy of fusion(△H) and specific heat(C_p) for the same alloy was also determined by means of differential scanning calorimeter(DSC) from heating trace during the transformation from eutectic liquid to eutectic solid. | KAYA Hasan ENGÍN Sevda AKER Aynur BüYüK Ugur ÇADIRLI Emin | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，1： | 2 |
| 4 | Germline Epigenetic Regulation of KILLIN in Cowden and Cowden-like Syndrome 显示文摘 | Bennett K L Mester J Eng C | 2010 | J AMA-J Am Med Assoc2010，304，24： | 1 |
| 5 | Identification and characterization of wheat grain albumin/globulin allergens显示文摘 | WEISS W HUBER G ENGE K H | | 0，，： | 1 |
| 6 | Glutamine deprivation stimulates m TOR-JNK-dependent chemokine secretion显示文摘 | Shanware NP Bray K Eng CH | 2014 | Nature Communications2014，，5： | 1 |
| 7 | Dipeptidyl-peptidase-Ⅳinhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients显示文摘 | Boschmann M Engeli S Dobberstein K | 2009 | J Clin Endocrinol Metab2009，94，3： | 1 |
| 8 | Does financial develop- ment cause economic growth? A panel data dynamic analysis for the Asian developing countries 显示文摘 | HABIBULLAH M S ENG Y K | 2006 | Journal of the Asia Pacific Economy2006，11，4： | 1 |
| 9 | The adipose tissue rennin-angiotensin-aldosterone system:role in the metabolic syndrome?显示文摘 | Engeli S Schling P Gorzelniak K | 2003 | Int J Biochem Cell Biol2003，35，6： | 1 |
| 10 | Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension显示文摘 | GORZELNIAK K ENGELI S JANKE J | 2002 | J Hypertens2002，20，： | 1 |
| 11 | A role for NF -κB -- dependent gene transactivation in sunburn 显示文摘 | Abeyama K Eng W Jester JV | 2000 | J Clin Investig2000，105，12： | 1 |
| 12 | Noise adaptive soft-switching median filter显示文摘 | ENG H MA K | 2001 | IEEE Trans on Image Processing2001，10，2： | 1 |
| 13 | The nuclear affairs of PTEN 显示文摘 | Planchon S M Waite K A Eng C | 2008 | J Cell Sci2008，121，3： | 1 |
| 14 | Noise adaptive soft-switching median filter显示文摘 | Eng H L Ma K K | 2001 | IEEE Transactions on Image Processing2001，10，2： | 1 |
| 15 | Hormonal regulation of the human adlpose-tissue renin-anglotensin system : relationship to obesity and hypertension显示文摘 | Gorzelniak K Engeli S Janke J | 2002 | Hypertens2002，20，5： | 1 |
| 16 | Cervical Cancer Prevention: A- sian - American Women's Knowledge and Participation in Screening Practices显示文摘 | Robison K Clark L Eng W | 2014 | Womens Health Issues2014，24，2： | 1 |
| 17 | Resistin gene expression in human adipocytes is not related to insulin resistance 显示文摘 | JANKE J ENGELI S GORZELNIAK K | 2002 | Obesity Research2002，10，1： | 1 |
| 18 | Mature adipoeytes inhibit in vitro differentiation of human preadipoeytes via angiotensin type 1 receptors 显示文摘 | Janke J Engeli S Gorzelniak K | 2002 | Diabetes2002，51，6： | 1 |
| 19 | Both resistance and agility training reduce back pain and improve health-related quality of life in olde rwomen with low bone mass显示文摘 | Liu-Ambrose T Y L Khan K M Eng J J | 2005 | Osteoporos Int2005，16，： | 1 |
| 20 | Association between adiponectin and mediators of inflammation in obese women 显示文摘 | Engeli S Feldpausch M Gorzelniak K | 2003 | Diabetes2003，，： | 1 |
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