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| 1 | New insight into inter-organ crosstalk contributing to the pathogenesis of non- alcoholic fatty liver disease (NAFLD)显示文摘非酒精的脂肪肝疾病(NAFLD ) 与在在最后十年的流行的实质的上升是长期的肝机能障碍和一个重要全球健康问题的最普通的原因。NALFD 主要是新陈代谢的症候群的肝的表明,正在变得逐渐地清楚不仅,而且包含额外肝的机关和规章的小径。治疗学的选择为 NAFLD 的处理被限制。因此, NAFLD 的致病的更好的理解为获得新卓见进 NAFLD 并且为为 NAFLD 的预防和处理识别新目标的规章的网络是批评的。在这评论,我们在在肝和外部机关之间的内部器官的串音的当前的理解上强调贡献 NAFLD 的致病。 | Xu Zhang Xuetao Ji Qian Wang John Zhong Li | 2018 | Protein & Cell2018，9，2： | 14 |
| 2 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 3 | Numerical investigation of particle saltation in the bed-load regime显示文摘This paper numerically investigates particle saltation in a turbulent channel flow having a rough bed consisting of 2–3 layers of densely packed spheres.In this study,we combined three the state-of-the-art technologies,i.e.,the direct numerical simulation of turbulent flow,the combined finite-discrete element modelling of the deformation,movement and collision of the particles,and the immersed boundary method for the fluid-solid interaction.Here we verify our code by comparing the flow and particle statistical features with the published data and then present the hydrodynamic forces acting on a particle together with the particle coordinates and velocities,during a typical saltation.We found strong correlation between the abruptly decreasing particle stream-wise velocity and the increasing vertical velocity at collision,which indicates that the continuous saltation of large grain-size particles is controlled by collision parameters such as particle incident angle,local rough bed packing arrangement,and particle density,etc.This physical process is different from that of particle entrainment in which turbulence coherence structures play an important role.Probability distribution functions of several important saltation parameters and the relationships between them are presented.The results show that the saltating particles hitting the windward side of the bed particles are more likely to bounce off the rough bed than those hitting the leeside.Based on the above findings,saltation mechanisms of large grain-size particles in turbulent channel flow are presented. | JI ChunNing ANTE Munjiza ELDAD Avital XU Dong JOHN Williams | 2014 | Science China(Technological Sciences)2014，57，8： | 10 |
| 4 | Equal Efficacy of Endoscopic and Surgical Cystogastrostomy for Pancreatic Pseudocyst Drainage in a Randomized Trial显示文摘 | Shyam Varadarajulu Ji Young Bang Bryce S. Sutton Jessica M. Trevino John D. Christein C. Mel Wilcox | 2013 | Gastroenterology2013，，： | 6 |
| 5 | Accelerated flow softening and dynamic transformation of Ti-6Al-4V alloy in two-phase region during hot deformation via coarsening αgrain显示文摘The flow softening is an important phenomenon during hot deformation of metallic materials.In the present work,a more evident flow softening of Ti-6 Al-4 V alloy when deformed in two-phase region was observed in coarser a grain sample,which was attributed to an accelerated dynamic transformation from harder α phase into β phases.Notably,full β microstructure was observed in coarse grain samples at strain of 1.2,while retained a phase was observed in fine a grain specimens.In the views of thermodynamics and crystallographic analysis,the in-depth mechanisms of dynamic transformation were further investigated. | Xiankun Ji Baoqi Guo Fulin Jiang Hong Yu Dingfa Fu Jie Teng Hui Zhang John J.Jonas | 2020 | Journal of Materials Science & Technology2020，36，1： | 5 |
| 6 | Trabecular Plate Loss and Deteriorating Elastic Modulus of Femoral Trabecular Bone in Intertrochanteric Hip Fractures显示文摘Osteoporotic hip fracture is associated with significant trabecular bone loss,which is typically characterized as low bone density by dual-energy X-ray absorptiometry(DXA)and altered microstructure by micro-computed tomography(μCT).Emerging morphological analysis techniques,e.g.individual trabecula segmentation(ITS),can provide additional insights into changes in plate-like and rod-like trabeculae,two major micro-structural types serving different roles in determining bone strength.Using ITS,we evaluated trabecular microstructure of intertrochanteric bone cores obtained from 23 patients undergoing hip replacement surgery for intertrochanteric fracture and 22 cadaveric controls.Micro-finite element(μFE)analyses were performed to further understand how the abnormalities seen by ITS might translate into effects on bone strength.ITS analyses revealed that,near fracture site,plate-like trabeculae were seriously depleted in fracture patients,but trabecular rod volume was maintained.Besides,decreased plate area and rod length were observed in fracture patients.Fracture patients also showed decreased elastic moduli and shear moduli of trabecular bone.These results provided evidence that in intertrochanteric hip fracture,preferential loss of plate-like trabeculae led to more rod-like microstructure and deteriorated mechanical competence adjacent to the fracture site,which increased our understanding of the biomechanical pathogenesis of hip fracture in osteoporosis. | Ji Wang Bin Zhou Ian Parkinson C.David L.Thomas John G.Clement Nick Fazzalari X.Edward Guo | 2013 | Bone Research2013，1，4： | 4 |
| 7 | Cost-efficient Thermal Management for a 48V Li-ion Battery in a Mild Hybrid Electric Vehicle显示文摘The 48V mild hybrid system is a cost-efficient solution for original equipment manufacturers to meet increasingly stringent fuel consumption requirements.However,hybrid functions such as auto-stop/start and brake regeneration are unavailablewhen a 48V battery is at very low temperature because of its limited charge and discharge capability.Therefore,it is important to develop cost-efficient thermal management to warm-up the battery of a 48V mild hybrid electric vehicle(HEV)to recover hybrid functions quickly in cold climate.Following the model-based“V”process,we first define the requirements and then design different mechanisms to heat a 48V battery.Afterward,we build a 48V battery model in LMS AMESim and conduct co-simulation with simplified battery management system and hybrid control unit algorithms in MATLAB Simulink for analysis.Finally,we carry out a series of vehicle experiments at low temperature and observe the effect of heating to validate the design.Both simulation results and experimental data show that a cold 48V battery placed in a cabin with hot air can be heated effectively in the developed“Enhanced Generator Mode with 48V Battery”mode.The entire design is in a newly developed software that cyclically charges and discharges a 48V battery for quick warm-up in cold temperature without needing any additional hardware such as a heater,making it a cost-efficient solution for HEVs. | Chao Yu Guangji Ji Chao Zhang John Abbott Mingshen Xu Pieter Ramaekers Jianxiang Lu | 2018 | Automotive Innovation2018，1，4： | 3 |
| 8 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 9 | Further geological and palaeoanthropological investigations at the Maludong hominin site, Yunnan Province, Southwest China显示文摘Three-dimensional mapping and section work undertaken by us in 2008 have identified 11 stratigraphic units at Maludong site.AMS radiocarbon dating of charcoal established an accurate and internally consistent age profile for the sequence of 17.8±0.2 ka to 13.2±0.1 ka.Archaeomagnetic analysis showed changes in externally derived pedogenically enhanced material consistent with a warming in climate between the cold period of Henrich Event 1 and the B lling-Aller d interstadial.Human remains recovered during the 1989 excavation were derived from a deposit dating to this interstadial,or between 14.3±0.3 ka and 13.5±0.1 ka.Anthropogenic features,including burnt rocks,baked sediment and thick charcoal and ash layers,were identified and examined through archaeomagnetic analysis.Two monkey fossils are described here,one of them being reassigned from Macaca robustus to M.aff.M.assamensis.They confirm the young age of the site and also show signs of anthropogenic alteration in the form of burning.Additional human cranial remains are reported for the first time and new data are provided for some specimens described previously.A range of new features is identified that strengthen the affinities of the Maludong remains to archaic humans.The presence of this globally unique mosaic of archaic and modern features raises important questions about human evolutionary history in East Asia during the Late Upper Pleistocene. | JI XuePing CURNOE Darren BAO ZhenDe HERRIES Andy I R FINK David ZHU YunSheng HELLSTROM John LUO Yun TACON Paul S C | 2013 | Chinese Science Bulletin2013，58，35： | 3 |
| 10 | Effects of Early Intensive Blood Pressure-Lowering Treatment on the Growth of Hematoma and Perihematomal Edema in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)显示文摘 | Craig S. Anderson Yining Huang Hisatomi Arima Emma Heeley Christian Skulina Mark W. Parsons Bin Peng Qiang Li Steve Su Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Lewis B. Morgenstern John Chalmers Ji Guang Wang | 2010 | Stroke2010，，2： | 3 |
| 11 | Lineage relationship of CD8^+ T cell subsets is revealed by progressive changes in the epigenetic landscape显示文摘 | Joseph G. Crompton Manikandan Narayanan Suresh Cuddapah Rahul Roychoudhuri Yun Ji Wenjing Yang Shashank J. Patel Madhusudhanan Sukumar Douglas C. Palmer Weiqun Peng Ena Wang Francesco M. Marincola Christopher A. Klebanoff Keji Zhao John S. Tsang Luca Gatt-inoni Nicholas P. Restifo | 2016 | Cellular & Molecular Immunology2016，13，4： | 2 |
| 12 | Optimizing beam transport in rapidly compressing beams on the neutralized drift compression experiment-II显示文摘The Neutralized Drift Compression Experiment-II(NDCX-II)is an induction linac that generates intense pulses of 1.2 MeV helium ions for heating matter to extreme conditions.Here,we present recent results on optimizing beam transport.The NDCX-II beamline includes a 1-m-long drift section downstream of the last transport solenoid,which is filled with charge-neutralizing plasma that enables rapid longitudinal compression of an intense ion beam against space-charge forces.The transport section on NDCX-II consists of 28 solenoids.Finding optimal field settings for a group of solenoids requires knowledge of the envelope parameters of the beam.Imaging the beam on the scintillator gives the radius of the beam,but the envelope angle is not measured directly.We demonstrate how the parameters of the beam envelope(radius,envelop angle,and emittance)can be reconstructed from a series of images taken by varying the B-field strengths of a solenoid upstream of the scintillator.We use this technique to evaluate emittance at several points in the NDCX-II beamline and for optimizing the trajectory of the beam at the entry of the plasma-filled drift section. | Anton D.Stepanov John J.Barnard Alex Friedman Erik P.Gilson David P.Grote Qing Ji Igor D.Kaganovich Arun Persaud Peter A.Seidl Thomas Schenkel | 2018 | Matter and Radiation at Extremes2018，3，2： | 2 |
| 13 | Development of a corpus of Mandarin sentences in babble with homogeneity optimized via psychometric evaluation显示文摘 | Xin Xi Teresa Y.C. Ching Fei Ji Yang Zhao Jia-Nan Li John Seymour Meng-Di Hong Ai-Ting Chen Harvey Dillon | 2012 | International Journal of Audiology2012，，5： | 1 |
| 14 | Preparation and characterization of organic-soluble acetylated starch nanocrystals显示文摘 | Yue Xu Wanqiang Ding Ji Liu Ya Li John F. Kennedy Qun Gu Shuangxi Shao | 2010 | Carbohydrate Polymers2010，，4： | 1 |
| 15 | How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center显示文摘 | John O. Clarke Samuel A. Giday Priscilla Magno Eun Ji Shin Jonathan M. Buscaglia Sanjay B. Jagannath Gerard E. Mullin | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 16 | Theodore nicholas, fatigue crack nucleation and growth rate behavior of laser shock peened titanium显示文摘 | Ruschau J J John Re Ji Thompson S R | 1999 | International Journal of Fatigue1999，21，： | 1 |
| 17 | Simultaneous determi-nation of pioglitazone and its two active metabolites in human plasma by LC-/MS/MS 显示文摘 | Zhongping John Lin Ji Weihua Daksha Desai-Krieger | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，33，： | 1 |
| 18 | Distribution characteristics of inertial sediment particles in the turbulent boundary layer of an open channel flow determined using Voronoi analysis显示文摘This paper presents the numerical investigation of the distribution of inertial sediment particles in the turbulent boundary layer of an open channel flow with the particle Stokes number ranging from 0.6 to 20.4. The methodology is a combination of three numerical approaches, i.e. direct numerical simulation of turbulent flow, the point-particle immersed boundary method, and the discrete particle method. By applying the Vorono analysis, the preferential concentration characteristics of sediment particles were investigated quantitatively. It was found that the normalized area of the Voronoi cells follows a lognormal particle distribution. The inertial sediment particles distributed unevenly in the turbulent boundary layer and the unevenness, governed by the particle Stokes number, was more significant as the particle Stokes number approaches unity. The inertial sediment particles in the turbulent boundary layer accumulated preferentially in streamwise-aligned streaky structures and this pattern was less significant with increasing particle Stokes number. | Xin Liu Chunning Ji Xiaoli Xu Dong Xu John J.R. Williams | 2017 | International Journal of Sediment Research2017，32，3： | 1 |
| 19 | Simultaneous determination of pioglitazone and its two active metabolites in human plasma by LC-/MS/MS显示文摘 | Zhongping john lin Weihua ji Daksha desai krieger | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，33，： | 1 |
| 20 | Cryptosporidium erinacei n. sp. (Apicomplexa: Cryptosporidiidae) in hedgehogs显示文摘 | Martin Kvá? Lada Hofmannová Lenka Hlásková Dana Květoňová Ji?í Vítovec John McEvoy Bohumil Sak | 2014 | Veterinary Parasitology2014，，： | 1 |
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