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| 1 | Exploration of the formation mechanism and source attribution of ambient ozone in Chongqing with an observation-based model显示文摘An intensive field campaign was conducted in Chongqing during the summer of 2015 to explore the formation mechanisms of ozone pollution. The sources of ozone, the local production rates, and the controlling factors, as well as key species of volatile organic compounds(VOCs), were quantified by integrating a local ozone budget analysis, calculations of the relative incremental reactivity, and an empirical kinetic model approach. It was found that the potential for rapid local ozone formation exists in Chongqing. During ozone pollution episodes, the ozone production rates were found to be high at the upwind station Nan Quan, the urban station Chao Zhan, and the downwind station Jin-Yun Shan. The average local ozone production rate was 30×10^(-9) V/V h^(-1) and the daily integration of the produced ozone was greater than 180×10^(-9) V/V. High ozone concentrations were associated with urban and downwind air masses. At most sites, the local ozone production was VOC-limited and the key species were aromatics and alkene, which originated mainly from vehicles and solvent usage. In addition, the air masses at the northwestern rural sites were NO_x-limited and the local ozone production rates were significantly higher during the pollution episodes due to the increased NOx concentrations. In summary, the ozone abatement strategies of Chongqing should be focused on the mitigation of VOCs. Nevertheless, a reduction in NO_x is also beneficial for reducing the regional ozone peak values in Chongqing and the surrounding areas. | SU Rong LU KeDing YU JiaYan TAN ZhaoFeng JIANG MeiQing LI Jing XIE ShaoDong WU YuSheng ZENG LiMin ZHAI ChongZhi ZHANG YuanHang | 2018 | Science China Earth Sciences2018，61，1： | 24 |
| 2 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 3 | PtrHB7, a class III HD-Zip Gene, Plays a Critical Role in Regulation of Vascular Cambium Differentiation in Populus显示文摘在树的第二等的生长的一个关键问题是脉管的形成层房间的区别怎么被指导到 concurrentlyform 二不同纸巾:木部或韧皮部。类 III homeodomain 白氨酸拉链(HD 压缩 III ) 基因被知道在主要、第二等的 growth.However 的进程在脉管的系统的开始, patterning,和区别玩 criticalroles,这些基因怎么控制第二等的脉管的区别的机制是未知的。这里,我们显示出那 Populus 类 III HD 压缩基因, PtrHB7,优先地在 cambial 被表示地区。压制 PtrHB7 的植物在木部与减小在脉管的纸巾显示了重要变化但是韧皮部的增加。Transcriptionalanalysis 表明调整木部区别的基因是下面调整的,而基因调整韧皮部 differentiationwere 起来调整。相应地, PtrHB7 overexpression 向木部房间提高了 cambial 房间的区别,但是禁止了韧皮部区别。cambial 房间区别上的 PtrHB7 规定与它的抄本丰富被联系。一起,结果 demonstratedthat PtrHB7 在在剂量依赖者 manner.Key 在 processof Populus 第二等的生长控制在第二等的木部和韧皮部纸巾之间的平衡区别起一个关键作用词: | Yingying Zhu Dongliang Song Jiayan Sun Xingfen Wang Laigeng Li | 2013 | Molecular Plant2013，6，4： | 13 |
| 4 | Phosphorylation of LTF1, an MYB Transcription Factor in Populus, Acts as a Sensory Switch Regulating Lignin Biosynthesis in Wood Cells显示文摘Lignin is specifically deposited in plant secondary cell walls,and initiation of lignin biosynthesis is regulated by a variety of developmental and environmental signals.However,the mechanisms governing the regulation of lignin biosynthesis remain to be elucidated.In this study,we identified a lignin biosynthesis-associated transcription factor(LTF)from Populus,LTF1,which binds the promoter of a key lignin biosynthetic gene encoding 4-coumarate-CoA ligase(4CL).We showed that LTF1 in its unphosphorylated state functions as a regulator restraining lignin biosynthesis.When LTF1 becomes phosphorylated by PdMPK6 in response to external stimuli such as wounding,it undergoes degradation through a proteasome pathway,resulting in activation of lignification.Expression of a phosphorylation-null mutant version of LTF1 led to stable protein accumulation and persistent attenuation of lignification in wood cells.Taken together,our study reveals a mechanism whereby LTF1 phosphorylation acts as a sensory switch to regulate lignin biosynthesis in response to environmental stimuli.The discovery of novel modulators and mechanisms modifying lignin biosynthesis has important implications for improving the utilization of cell-wall biomass. | Jinshan Gui Laifu Luo Yu Zhong Jiayan Sun Toshiaki Umezawa Laigeng Li | 2019 | Molecular Plant2019，12，10： | 10 |
| 5 | Tolerance of Physocypria kraepelini (Crustacean, Ostracoda) to water-borne ammonia, phosphate and pH value显示文摘This study evaluated the median lethal concentration (LC50) and safe concentration of water-borne ammonia, phosphate and pH value on Physocypria kraepelini, a freshwater Ostracoda with a static renewal test system. The results indicated that the LC50 values of ammonia for P. kraepelini were 1026.71, 859.98, 771.79 and 583.82 mg/L at 24, 48, 72 and 96 h exposure, respectively, and the safe concentration range of ammonia for the long-term survival of P. kraepelini was less than 58.38 mg/L. The safe range of pH value for the survival of P. kraepelini was from 6.59 to 7.61. P. kraepelini has a high tolerance to ammonia, phosphate and pH value which are the main environmental factors in the serious eutrophication water. | YU Na, CHEN Shimei, LI Erchao, CHEN Jiayan, CHEN Liqiao School of Life Science, East China Normal University, Shanghai 200062, China | 2009 | Journal of Environmental Sciences2009，21，11： | 4 |
| 6 | CRISPR-Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma:a cross-talk between FGF21 and the NRF2 pathway显示文摘The treatment of hepatocellular carcinoma(HCC)has been dominated by multikinase inhibitors for more than a decade.However,drug resistance can severely restrict the efficacy of these drugs.Using CRISPR/CAS9 genome library screening,we evaluated Kelch-like ECH-associated protein 1(KEAP1)as a key regulator of sorafenib’s susceptibility in HCC.We also investigated whether KEAP1’s knockdown can stabilize nuclear factor(erythroid-derived 2)-like 2(NRF2)protein levels that led to sorafenib’s resistance,including an NRF2 inhibitor that can synergize with sorafenib to abolish HCC’s growth in vitro and in vivo.Furthermore,we clarified that fibroblast growth factor 21(FGF21)is an important downstream regulator of NRF2 in HCC.Intriguingly,we observed that FGF21 bound to NRF2 through the C-terminus of FGF21,thereby stabilizing NRF2 by reducing its ubiquitination and generating a positive feedback loop in sorafenib-resistant HCC.These findings,therefore,propose that targeting FGF21 is a promising strategy to combat HCC sorafenib’s resistance. | Jiang Chen Shi Jiang Huijiang Shao Bixia Li Tong Ji Daniel Staiculescu Jiayan He Jie Zhao Liuxin Cai Xiao Liang Junjie Xu Xiujun Cai | 2022 | Science China(Life Sciences)2022，65，10： | 4 |
| 7 | Transcriptomic analysis reveals key regulators of mammogenesis and the pregnancy-lactation cycle显示文摘An organ unique to mammals,the mammary gland develops 90%of its mass after birth and experiences the pregnancy-lactation-involution cycle(PL cycle)during reproduction.To understand mammogenesis at the transcriptomic level and using a ribo-minus RNA-seq protocol,we acquired greater than 50 million reads each for the mouse mammary gland during pregnancy(day 12 of pregnancy),lactation(day 14 of lactation),and involution(day 7 of involution).The pregnancy-,lactation-and involution-related sequencing reads were assembled into 17344,10160,and 13739 protein-coding transcripts and1803,828,and 1288 non-coding RNAs(ncRNAs),respectively.Differentially expressed genes(DEGs)were defined in the three samples,which comprised 4843 DEGs(749 up-regulated and 4094 down-regulated)from pregnancy to lactation and4926 DEGs(4706 up-regulated and 220 down-regulated)from lactation to involution.Besides the obvious and substantive upand down-regulation of the DEGs,we observe that lysosomal enzymes were highly expressed and that their expression coincided with milk secretion.Further analysis of transcription factors such as Trps1,Gtf2i,Tcf7l2,Nupr1,Vdr,Rb1,and Aebp1,and ncRNAs such as mir-125b,Let7,mir-146a,and mir-15 has enabled us to identify key regulators in mammary gland development and the PL cycle. | ZHOU YuanYuan GONG Wei XIAO JingFa WU JiaYan PAN LinLin LI XiaoNuan WANG XuMin WANG WeiWei HU SongNian YU Jun | 2014 | Science China(Life Sciences)2014，57，3： | 4 |
| 8 | PtrCel9A6, an Endo-l,4-β-Glucanase, Is Required for Cell Wall Formation during Xylem Differentiation in Populus显示文摘 | Liangliang Yu Jiayan Sun Laigeng Li | 2013 | Molecular Plant2013，6，6： | 3 |
| 9 | Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through phosphatidylinositol-3-kinase/protein kinase B signaling pathway and transcription factor specificity protein 1 in BGC823 cell line显示文摘Multidrug 抵抗(MDR ) 是化疗失败和癌复发的最重要的原因之一。但是 rolesof 在 MDR 遗体的联系 MDR 的蛋白质 MRP1 糟糕理解。脉管的 endothelial 生长因素(VEGF ) , themost 之一活跃、特定的脉管的生长因素,在增长,区别,和 metastasisof 癌症起一个重要作用。在 MRP1 的表示上探索 VEGF 的效果,我们使用了 recombinant 人 VEGF 刺激 K562 andBGC-823 房间线。量的即时聚合酶链反应和西方的污点分析证明在 mRNA 和蛋白质层次的 expressionof MRP1 被增加。3-(4,5-Dimethylthiazol-2-yl )-2,5-diphenyl tetrazolium 溴化物 resultsalso 证明 VEGF 显著地提高了与 adriamycin 对待的房间的 IC 50 。探索内在的规章的机制,我们构造了 MRP1 倡导者和 theluciferase 记者基因 recombinant 向量。,酶记者基因试金证明 MRP1 倡导者的活动被 VEGF 刺激显著地增加 LY294002, phosphatidylinositol-3-kinase (PI3K ) 的一个禁止者表明小径的 /proteinkinase B (Akt ) ,减少了这效果。抄写因素特性蛋白质 1 (SP1 ) 有约束力的地点 mutationpartially 由 VEGF 堵住了 MRP1 倡导者活动的起来规定。在摘要,我们的结果表明了 MRP1 的那 VEGF enhancedthe 表情,并且表明小径和 SP1 的 PI3K/Akt 可以涉及这调整。 | Juan Li Xiaojun Wu Jinling Gong Jing Yang Jiayan Leng Qiaoyun Chen Wenlin Xu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 2 |
| 10 | The 1 PW/0.1 Hz laser beamline in SULF facility显示文摘In this paper,we report the recent progress on the 1 PW/0.1 Hz laser beamline of Shanghai Superintense Ultrafast Laser Facility(SULF).The SULF-1 PW laser beamline is based on the double chirped pulse amplification(CPA)scheme,which can generate laser pulses of 50.8 J at 0.1 Hz after the final amplifier;the shot-to-shot energy fluctuation of the amplified pulse is as low as 1.2%(std).After compression,the pulse duration of 29.6 fs is achieved,which can support a maximal peak power of 1 PW.The contrast ratio at-80 ps before main pulse is measured to be 2.5×10^-11.The focused peak intensity is improved by optimizing the angular dispersion in the grating compressor.The maximal focused peak intensity can reach 2.7×10^19W/cm2 even with an f/26.5 off-axis parabolic mirror.The horizontal and vertical angular pointing fluctuations in 1 h are measured to be 1.89 and 2.45μrad,respectively.The moderate repetition rate and the good stability are desirable characteristics for lasermatter interactions.The SULF-1 PW laser beamline is now in the phase of commissioning,and preliminary experiments of particle acceleration and secondary radiation under 300–400 TW/0.1 Hz laser condition have been implemented.The progress on the experiments and the daily stable operation of the laser demonstrate the availability of the SULF-1 PW beamline. | Zongxin Zhang Fenxiang Wu Jiabing Hu Xiaojun Yang Jiayan Gui Penghua Ji Xingyan Liu Cheng Wang Yanqi Liu Xiaoming Lu Yi Xu Yuxin Leng Ruxin Li Zhizhan Xu | 2020 | High Power Laser Science and Engineering2020，8，1： | 2 |
| 11 | Nanocrystalline La2Mo2O9 and Its Characterization显示文摘In this work, both the thermal expansion and electrical conductivity of nanocrystalline La2Mo2O9 were studied.The nanocrystalline powder of La2Mo2O9 was obtained by sol-gel method, and with the help of SHP (superhigh pressure)up to 4.5 × 104 atm at 700 ℃ for a short time, and the nanocrystalline powder was densified without obvious particle size growth. The electrical conductivity of nanocrystalline La2Mo2O9 was one orderof magnitude lower than that of the microcrystalline sample at the same temperature. Owing to the phase transition, the microcrystalline La2Mo2O9 has an abrupt increase of thermal expansion with a peak value of 48 × 10-6 K-1 at 556 ℃. For the nanocrystalline material, the peak value increases to 112 × 10-6 K-1 at 520 ℃. On the other hand, above 600 ℃ the significant growth of particle size of the nanocrystalline La2Mo2O9 was observed, accompanying by a tremendous increase of thermal expansion with a peak value of third higher than that of La2Mo2O9. | Li Qin Xia Tian Li Jiayan Liu Xiangdong Ma Xianfeng Meng Jian Cao Xueqiang | 2004 | Journal of Rare Earths2004，22，z2： | 2 |
| 12 | Evaluating the bioavailability of heavy metals in natural-zeoliteamended aquatic sediments using thin-film diffusive gradients显示文摘The effectiveness of natural zeolite amendment of sediments as a restorative material was studied,as was the feasibility of utilizing thin-film gradient diffusion(DGT)as a proxy for the accumulation of heavy metals in Venerupis philippinaram.The results showed that addition of natural zeolite to sediment,significantly decreased the equilibrium partitioning of Cu,Pb,Cd,Cr and As between the sediment pore water and natural zeolite over 24 h by 67%,81%,72%,62%and 71%,respectively.Furthermore,the accumulation of Cu,Pb,Cd,Cr and As in V.philippinaram in the zeolite-amended sediments decreased by 44%,37%,54%,30%and 59%,respectively after 28 days and the absorption rates also declined.The amount of heavy metals enriched into the DGT film and V.philippinaram over 28 days showed a significant correlation(P<0.001)and indicated that DGT has the potential as a proxy to predict the bioaccumulation of heavy metals in benthic organisms in sediments amended by natural zeolite.Further studies focused on the modification of natural zeolite and the predictive ability of DGT in different sediments/organism scenarios are warranted. | Juanying Li Chen Zhang Jianwei Lin Jie Yin Jiayan Xu Yiqin Chen | 2018 | Aquaculture and Fisheries2018，3，3： | 2 |
| 13 | Selective Synthesis of Mesoporous and Nanorod CeVO4 without Template显示文摘 | Ling Zhu Qin Li Jiayan Li Xiangdong Liu Jian Meng Xueqiang Cao | 2007 | Journal of Nanoparticle Research2007，，2： | 1 |
| 14 | La 2 (Zr 0.7 Ce 0.3 ) 2 O 7 —A new oxide ceramic material with high sintering-resistance显示文摘 | Xueqiang Cao Jiayan Li Xinghua Zhong Jiangfeng Zhang Yanfei Zhang Robert Vassen Detlev Stoever | 2008 | Materials Letters2008，，17： | 1 |
| 15 | Power,Society,and Living Space: Evolution and Formation Mechanism of Urban Streets in China显示文摘Being one of the most important elements of urban public space, streets have contained rich social lives as well as the social and political connotations in Chinese cities with specific local characteristics, while most of them have been long neglected in the researches focusing on grand narratives and center-based perspectives. The paper retrospectively analyzes the evolution process of urban streets in China, dividing it into four critical periods. With the perspective of socio-spatial analysis, the unique formation mechanisms of Chinese urban streets are summarized in different contexts including power system, social domain, and living space, thus to provide references for the exploration of street development mode and revitalization mechanism facing the multiple challenges of globalization, modernity, as well as local social and cultural traditions. | Jiayan LIU Xiangyu DENG Caige LI | 2013 | China City Planning Review2013，22，1： | 1 |
| 16 | High‑Performance Flexible Microneedle Array as a Low‑Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography显示文摘Microneedle array(MNA)electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications.Existing schemes are limited by flexibility,biosafety,and manufacturing costs,which create large barriers for wider applications.Here,we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface,robustness of microneedles to penetrate the skin without fracture,and a simplified process to allow mass production.The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording.The normalized electrode–skin contact impedance reaches 0.98 kΩcm^(2)at 1 kHz and 1.50 kΩcm^(2)at 10 Hz,a record low value compared to previous reports and approximately 1/250 of the standard electrodes.The morphology,biosafety,and electrical/mechanical properties are fully characterized,and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized.The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording(over 8 h per night),providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes. | Junshi Li Yundong Ma Dong Huang Zhongyan Wang Zhitong Zhang Yingjie Ren Mengyue Hong Yufeng Chen Tingyu Li Xiaoyi Shi Lu Cao Jiayan Zhang Bingli Jiao Junhua Liu Hongqiang Sun Zhihong Li | 2022 | Nano-Micro Letters2022，14，8： | 1 |
| 17 | A diplexer for gigawatt class high power microwaves显示文摘 | Li Guolin Yuan Chengwei Zhang Jiayan | 2008 | Laser and Particle Beams2008，26，： | 1 |
| 18 | Zirconium nitride ( ZrN ) fibers prepared by carbothermal reduction and nitridation of electrospun PVP/zirconium oxychloride composite fibers显示文摘 | Li Jiayan Sun Yan Tan Yi | 2008 | Chemical Engineering Journal2008，144，1： | 1 |
| 19 | Research of boron removal from polysilicon using CaO–Al 2 O 3 –SiO 2 –CaF 2 slags显示文摘 | Jiayan Li Lei Zhang Yi Tan Dachuan Jiang Dengke Wang Yaqiong Li | 2014 | Vacuum2014，，： | 1 |
| 20 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
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