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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 3 | Novel 1xN and NxN Integrated Optical Switches Using Self-lmaging Multimode GaAs/Al-GaAs Waveguides显示文摘 | Jenkins R M Heaton J M Wright D R Parker J T Birbeck J C H Smith G W Hilton K P | 1994 | Appl Phys Lett 71994，64，： | 1 |
| 4 | Helium isotopes in geothermal systems: Iceland, The Geysers, Raft River and Steamboat Springs显示文摘 | Torgersen T Jenkins W J | 1982 | Geochimica et Cosmochimica Acta1982，46，： | 1 |
| 5 | Flash method of determining thermal diffusivity, heat capacity and thermal conductivity显示文摘 | Paker W J Jenkins R J Butter C P | 1961 | J Appl Phys1961，32，9： | 1 |
| 6 | The kink between dietary fibre and human health 显示文摘 | Kendall C W C Esfahani A Jenkins D J A | 2010 | Food Hydrocolloids2010，24，1： | 1 |
| 7 | Viscous and nonvis- cous fibres, nonabsorbable and low glycaemic index carbohy- drates, blood lipids and coronary heart disease显示文摘 | Jenkins D J Kendall C W Axelsen M | 2000 | Curr Opin Lipidol2000，11，1： | 1 |
| 8 | The contagion effects of accounting restatements显示文摘 | Gleason Cristi A Jenkins N T and Johnson W B | 2008 | The Accounting Review2008，83，16： | 1 |
| 9 | Absorptance, Emittance, and Thermal Efficiencies of Surfaces for Solar Spacecraft Power显示文摘 | BUTLER C P JENKINS R J PARKER W J | 1964 | Solar Energy1964，8，1： | 1 |
| 10 | Information Needs and Information Seeking in Community Medical Education显示文摘 | Cogdill K W Friedman C P Jenkins C G | 2000 | Academic Medicine2000，75，5： | 1 |
| 11 | Liquid Chromatographic Determination of Benzo(a)pyrene in the Total Particulate Matter of Cigarette Smoke显示文摘 | Tomkins B a Jenkins R A Gries W H | 1985 | J Assoc Off Anal Chem1985，68，： | 1 |
| 12 | Potential of polymeric lamellar substrate particles (PLSP) as adjuvants for vaccines显示文摘 | Jabbal-Gill I Lin W Jenkins P | 2000 | Vaccine2000，18，34： | 1 |
| 13 | Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised,placebo-controlled TORCH study 显示文摘 | Jenkins C R Jones P W Calverley P M | 2009 | Respir Res2009，10，： | 1 |
| 14 | The determination of geosmin and 2-methylisobomeol in water using isotope dilution high resolution mass spectrometry 显示文摘 | Palmentier J Taguchi V Y Jenkins S W D | 1998 | Water Research1998，32，2： | 1 |
| 15 | The use of orthogonal transform for improving performance of adaptive filters显示文摘 | Marshal D F Jenkin W K | 1989 | IEEE Trans on Circuits and System1989，36，4： | 1 |
| 16 | Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth显示文摘 | Jenkins Y Markovtsov V Lang W | 2005 | Mol Biol Cell2005，16，12： | 1 |
| 17 | 4D shear stress maps of the developing heart using Doppler optical coherence tomography 显示文摘 | Peterson L M Jenkins M W Gu S | 2012 | Biomed Opt Express2012，3，11： | 1 |
| 18 | Exposure to environmental tobacco smoke in sixteen cities in the United States as determined by personal breathing zone air sampling显示文摘 | JENKINS R A PALAUSKY A COUNTS R W | 1996 | Journal of Exposure Analysis and Environmental Epidemiology1996，6，4： | 1 |
| 19 | Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection显示文摘 | Jenkins C Garcia W Godwin MJ Spencer JV Stern JL Abendroth A Slobedman B | 2008 | J Virol2008，82，7： | 1 |
| 20 | Nitrate flux into the euphotic zone near Bermuda显示文摘 | Jenkins W J | 1988 | Nature1988，331，： | 1 |
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