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| 1 | 循证指南更新:成人发作性偏头痛预防的药物治疗显示文摘目的提供偏头痛预防治疗的指南更新推荐,所提出的临床问题是什么样的药物治疗可有效预防偏头痛发作?方法作者对1999年6月—2009年5月间发表的研究使用结构式的评价程序来分类不同(美国可获得)药物对偏头痛预防的效果。结果和推荐作者评价了284篇摘要,最后对29篇包含Ⅰ类或Ⅱ类证据的文章进行综述。双丙戊酸、丙戊酸钠、托吡酯、美托洛尔、普萘洛尔和噻吗洛尔能有效预防偏头痛,应该用于偏头痛患者以减少发作频率及程度(A级证据)。夫罗曲坦可有效预防月经性偏头痛(A级证据)。拉莫三嗪对偏头痛预防无效(A级证据)。 | 邹静 李颖 冯智英 李焰生 Silberstein SD Holland S Freitag F Dodick DW Argoff C Ashman E | 2012 | 神经病学与神经康复学杂志2012，9，2： | 38 |
| 2 | 循证指南更新:非甾体类抗炎药和其他辅助治疗预防成人发作性偏头痛显示文摘目的为偏头痛预防性治疗提供最新循证推荐。所提出的临床问题是非甾体类抗炎药(NSAIDs)或其他辅助治疗是否对偏头痛预防有效?方法作者对1999年6月—2009年5月间发表的研究使用结构式的评价程序来分类不同药物对偏头痛预防的效果。结果作者总共回顾了284篇摘要,包括49篇偏头痛预防治疗的Ⅰ级或Ⅱ级证据,其中15篇为涉及非传统治疗、NSAIDs及其他辅助治疗的研究,予以了评价。推荐蜂斗菜对偏头痛预防治疗有效,应被用于偏头痛患者以降低偏头痛发作频率及严重程度(A级推荐)。非诺洛芬、布洛芬、酮洛芬、萘普生、萘普生钠、雏菊、镁剂、核黄素及组胺皮下注射对偏头痛预防很可能有效(B级推荐)。认为可能有效的药物包括赛庚啶、辅酶Q10、雌激素、甲芬那酸及氟比洛芬(C级推荐)。矛盾不一致或不足以支持或反对使用的药物包括阿司匹林、吲哚美辛、ω-3及高压氧。孟鲁司特对偏头痛预防治疗很可能无效(B级证据)。 | 华驾略 蒋仙国 季伟华 李焰生 Holland S Silberstein SD Freitag F Dodick DW Argoff C Ashman E | 2012 | 神经病学与神经康复学杂志2012，9，2： | 17 |
| 3 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 4 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 5 | Initiating insulin therapy in type 2 diabetes:a comparison of biphasic and basal insulin analogs显示文摘 | Raskin R Allen E Hollander P | | Diabetes Care0，，： | 2 |
| 6 | Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohng disease and age-related changes in Th1/Th2 cytokine profiles 显示文摘 | Holland N Dong J Garnett E | 2008 | Pediatr Res2008，63，3： | 1 |
| 7 | Use of monoelonal antibodies to detect eonformational alterations in lactate dehydrogenase isoenzyme 5 on heat denaturation and on adsorption to polystyrene plates 显示文摘 | Hollander Z Katchalski-Katzir E | 1986 | Mol Immunol1986，23，9： | 1 |
| 8 | Surgical and visual outcomes of the type I Boston Kera- toprosthesis for the management of aniridic fibrosis syndrome in congenital aniridia 显示文摘 | Bakhtiari P Chan C Welder JD de la Cruz J Holland E J Djalil- ian AR | 2012 | Am J Ophthalmol2012，153，5： | 1 |
| 9 | Penetrating keratoplasty and transscler- al fixation of posterior chamber lens 显示文摘 | Holland E J Daya SM Evangelista A Ketcham JM Lubniewski A J Doughman D J | 1992 | Am J Ophthalmol1992，114，2： | 1 |
| 10 | 查看详情显示文摘 | Spindt C A Holland C E Brodie I | | 0，，01： | 1 |
| 11 | Clinical nurse specialist influence in the conduct of research in aclinical agency显示文摘 | Pamela J Nelson Diane E Holland Della Derscheid Sharon J Tucker | 2000 | Clinical nurse specialist CNS2000，21，2： | 1 |
| 12 | Obsessive--compulsive spectrum disorders:Over view and quality of life issues显示文摘 | HOLLANDER E KON J H STEIN D J | 1996 | J Clin Psychiatry1996，57，8： | 1 |
| 13 | Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection显示文摘 | Dorman S E Holland S M | 1998 | J Clin Invest1998，101，： | 1 |
| 14 | Classifier Systems and Genetic Algorithms显示文摘 | Booker L B Goldberg D E Holland J H | 1989 | Artificial Intelligence1989，40，： | 1 |
| 15 | Liquid Chromatographic Determination of The Anticoccidial Drug Halofuginone Hydrobromide in Eggs显示文摘 | Holland D C Munns R K Roybal J E | 1995 | J AOAC Int1995，78，1： | 1 |
| 16 | Venlafaxine in trentment-resistant obsessive-compulsive disorder显示文摘 | Hollander E Friedberg J Wasserman S | 2003 | J Clin Psychiatry2003，64，5： | 1 |
| 17 | An aggregate of public health indicator to response the impact of multiple environmental exposures 显示文摘 | Augustinus E M de Hollander Johan M Melse Erie Lebret | 1999 | Epidemiology1999，10，5： | 1 |
| 18 | Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma 显示文摘 | HOLLAND K E FRIEDEN I J FROMMELT P C | 2010 | Arch Dermatol2010，146，7： | 1 |
| 19 | Signs of central nervous system dysfunction in obsessive-compulsive disorde显示文摘 | HOLLANDER E SCHIFFMAN E COHEN B | 1990 | Arch Gen Psychiatry1990，47，1： | 1 |
| 20 | The relationship between repet- itive behaviors and growth hormone response to sumatriptan challenge in adult autistic disorder显示文摘 | Hollander E Novotny S Allen A | 2000 | Neuropsychopharmacology2000，22，2： | 1 |
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